全文获取类型
收费全文 | 226篇 |
免费 | 14篇 |
专业分类
儿科学 | 25篇 |
妇产科学 | 5篇 |
基础医学 | 17篇 |
口腔科学 | 6篇 |
临床医学 | 25篇 |
内科学 | 44篇 |
皮肤病学 | 3篇 |
神经病学 | 12篇 |
特种医学 | 3篇 |
外科学 | 13篇 |
综合类 | 6篇 |
预防医学 | 16篇 |
眼科学 | 3篇 |
药学 | 35篇 |
肿瘤学 | 27篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 10篇 |
2019年 | 6篇 |
2018年 | 1篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 8篇 |
2014年 | 4篇 |
2013年 | 8篇 |
2012年 | 11篇 |
2011年 | 10篇 |
2010年 | 13篇 |
2009年 | 3篇 |
2008年 | 18篇 |
2007年 | 10篇 |
2006年 | 15篇 |
2005年 | 17篇 |
2004年 | 18篇 |
2003年 | 8篇 |
2002年 | 11篇 |
2001年 | 7篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 2篇 |
1993年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1972年 | 1篇 |
1970年 | 3篇 |
1964年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有240条查询结果,搜索用时 15 毫秒
71.
72.
Mice were injected sc with benzene or one of its metabolites, phenol, catechol, or hydroquinone. The ability of these compound to inhibit erythropoiesis was quantified by measuring the incorporation of 59Fe into developing erythrocytes. Benzene decreased 59Fe incorporation into developing erythrocytes in a dose-dependent manner. Maximum inhibition was observed when benzene was administered 48 hr prior to initiation of the 59Fe uptake test. The three metabolites of benzene also significantly inhibited 59Fe incorporation when they were administered 48 hr prior to initiation of 59Fe uptake assay. The degree of inhibition observed with the metabolites was not as great as that observed with benzene. Coadministration of the microsomal mixed-function oxidase inhibitor, 3-amino-1,2,4-triazole, abolished the erythropoietic toxicity of benzene and phenol but had no effect on the catechol- or hydroquinone-induced toxicity. 相似文献
73.
William A. Krantz D.D.S. Colonel U.S. Army Chief Removable Prosthodontic Service Assistant Director Eric D. Adrian D.M.D. Lieutenant Colonel US Army DC Chief Removable Prosthodontic Service Assistant Director John R. Ivanhoe D.D.S. Assistant Chief Removable Prosthodontic Professor 《The Journal of prosthetic dentistry》1991,66(6):821-822
74.
LINDA L. ALEUNDER MAJOR US. ARMY NURSE CORPS RNC MSED MSN 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》1987,16(3):167-173
Evidence documents that smoking is especially detrimental to the unborn fetus and to the developing child. The reproductive risks associated with smoking are reviewed, and implications for nurses caring for the pregnant smoker are discussed. Strategies to assist patient smoking cessation efforts are outlined. Nurses must consider cigarette smoking in pregnancy to be as serious a risk factor to maternal and infant health as drugs and infectious diseases. 相似文献
75.
虽然社会心理因素在乳腺癌发生发展过程中的作用已经进行了大量的研究,但是在此过程中真正起作用的因素并不明确。因此,本研究对社会经济因素、心理因素和社会心理因素与乳腺癌生存率的相关性进行了研究。共102例72岁以下的乳腺癌患者完成了一项有效调查表,调查内容包括癌症应对、情绪表达、是否感知到理解和支持、癌症因素以外的生活压力以及诊断后三四个月内的生活质量等。 相似文献
76.
Debasish Paul Sehbanul Islam Rajesh Kumar Manne US Dinesh Sunil K Malonia Biswanath Maity Ramanamurthy Boppana Srikanth Rapole Praveen Kumar Shetty Manas Kumar Santra 《The Journal of pathology》2019,248(3):266-279
Aberrant activation of β-catenin has been implicated in a variety of human diseases, including cancer. In spite of significant progress, the regulation of active Wnt/β-catenin-signaling pathways is still poorly understood. In this study, we show that F-box protein 16 (FBXO16) is a putative tumor suppressor. It is a component of the SCF (SKP1-Cullin1-F-box protein) complex, which targets the nuclear β-catenin protein to facilitate proteasomal degradation through the 26S proteasome. FBXO16 interacts physically with the C-terminal domain of β-catenin and promotes its lysine 48-linked polyubiquitination. In addition, it inhibits epithelial-to-mesenchymal transition (EMT) by attenuating the level of β-catenin. Therefore, depletion of FBXO16 leads to increased levels of β-catenin, which then promotes cell invasion, tumor growth, and EMT of cancer cells. Furthermore, FBXO16 and β-catenin share an inverse correlation of cellular expression in clinical breast cancer patient samples. In summary, we propose that FBXO16 functions as a putative tumor suppressor by forming an SCFFBXO16 complex that targets nuclear β-catenin in a unique manner for ubiquitination and subsequent proteasomal degradation to prevent malignancy. This work suggests a novel therapeutic strategy against human cancers related to aberrant β-catenin activation. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. 相似文献
77.
Nodaviruses encode an RNA-dependent RNA polymerase called Protein A that is responsible for replication of the viral RNA segments. The intracellular localization of Protein A from a betanodavirus isolated from Atlantic halibut (AHNV) was studied in infected fish cells and in transfected mammalian cells expressing Myc-tagged wild type Protein A and mutants. In infected cells Protein A localized to cytoplasmic structures resembling mitochondria and in transfected mammalian cells the AHNV Protein A was found to co-localize with mitochondrial proteins. Two independent mitochondrial targeting signals, one N-terminal comprising residues 1–40 and one internal consisting of residues 225–246 were sufficient to target both Protein A deletion mutants and enhanced green fluorescent protein (EGFP) to the mitochondria. The N-terminal signal corresponds to the mitochondrial targeting sequence of the Flock House Virus (FHV) Protein A while the internal signal is similar to the single targeting signal previously found in Greasy Grouper Nervous Necrosis Virus (GGNNV) Protein A. 相似文献
78.
侵袭性NK细胞白血病的临床研究--附九例报告 总被引:11,自引:0,他引:11
上海市中美白血病协作课题组 《中华血液学杂志》2006,27(2):116-119
目的提高对侵袭性NK细胞白血病(ANKL)的认识,对其诊断标准进行总结。方法回顾性分析临床病例。结果和结论ANKL患者常有发热、肝脾肿大、黄疸、肝功能异常和全血细胞减少,疾病进展迅速,短期内出现多脏器功能衰竭、噬血细胞综合征,中位生存期小于2个月。目前较公认的诊断标准:①常有发热及肝、脾、淋巴结肿大;②外周血可以有中性粒细胞减少、贫血和血小板减少,淋巴细胞比例增高,大颗粒淋巴细胞可以增多,但不是诊断的必要条件;③骨髓涂片和活检均可见较多的大颗粒淋巴细胞浸润;④细胞免疫表型为CD2( ),表面CD3(-),胞质CD3( ),CD56( ), CD57(-),CD11b和CD16可以阳性,无T细胞受体重排;⑤有EB病毒抗体阳性的证据;⑥没有特异的染色体异常,较多见的核型异常为de1(6)(q21q25);⑦排除其他引起大颗粒淋巴细胞增多的疾病。 相似文献
79.
Berg AO Allan JD Frame PS Homer CJ Lieu TA Mulrow CD Orleans CT Peipert JF Pender NJ Sox HC Teusch SM Westhoff C Woolf SH;US Preventive Services Task Force 《The American journal of nursing》2002,102(10):87-92; discussion 93