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51.
52.
Alan G. Rose M.D. Neil G. Heselson M. Med. Richard K. Marks F.R.C.S. Dorothea Kranold F.F.RAD 《Skeletal radiology》1992,21(2):140-145
A man presented with a mass in the left first metacarpal bone. Later, his chest radiograph showed extensive, bilateral, rounded opacities in both lungs with enlarged hilar lymph nodes, and he developed expanding lesions in the left radius, ulna, and metacarpal bones. The pulmonary lesions were treated with radiotherapy and cytotoxic agents, and the tumor mass in the first metacarpal was debulked. All biopsies showed similar features of a mixed tumor (pleomorphic adenoma) with metastatic or embolic pulmonary involvement; ultrastructural and immunocytochemical investigations supported this unique diagnosis. The patient remains well 15 years after the initial diagnosis. It is possible that the myoepithelial elements in this case had been displaced intraosseously during development. We are not aware of a similar case in the literature. 相似文献
53.
Eugenija Zuskin E. Neil Schachter Bozica Kanceljak Jadranka Mustajbegovic Theodor J. Witek 《International archives of occupational and environmental health》1994,66(5):317-324
The relationship of skin reactivity and serum immunoglobulin E (IgE) levels to the prevalence of chronic respiratory symptoms and to ventilatory capacity is examined in workers exposed to different organic aerosols. The results from group of control workers similarly tested are also presented. Workers exposed to occupational allergens had positive skin tests more frequently than did controls, except for soy bean workers. Workers with positive skin tests to occupational allergens had a higher prevalence of almost all symptoms than those with negative skin tests although the differences did not always reach statistical significance. Workers with positive skin reactions in general had significantly higher serum IgE levels than did workers with negative skin reactions. There were across-shift reductions of ventilatory capacity in all groups of exposed workers, varying for forced vital capacity from 1.7% to 13.3%, for forced expiratory volume from 0.4%–21.9%, for maximum flow rates at 50% from 1.5% to 16.1% and for maximum flow rates at the last 25% of control vital capacity from 0% to 24.9%. There was, however, no correlation between acute and chronic lung function changes and skin reactivity or IgE values. Our data suggest that although exposure to organic aerosols may be associated with frequent immunologic reactions, these findings do not predict objective respiratory impairment.The research was supported in part by grant no. JBP 733 from the National Institutes of Health, Bethesda, Md., USA, and by grant no. RO1 OHO-2593-04 from the National Institutes of Occupational Safety and Health, Centers for Disease Control, Atlanta, Ga., USA 相似文献
54.
Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus 下载免费PDF全文
Martin Antonio Neil McFerran Mark J. Pallen 《Antimicrobial agents and chemotherapy》2002,46(2):438-442
The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 microg/ml contained point mutations affecting the Rossman fold via Val-to-Phe changes at either residue 588 (V588F) or residue 631 (V631F). The importance of the V588F mutation was confirmed by an allele-specific PCR survey of 32 additional strains. Additional mutations of uncertain significance were found in residues clustered on the surface of the IleS protein. 相似文献
55.
Role of nitric oxide in relaxation of the longitudinal layer of rectal smooth muscle 总被引:2,自引:2,他引:0
Mr. John F. Stebbing M.A. F.R.C.S. Alison F. Brading Ph.D. Neil J. McC Mortensen M.D. F.R.C.S. 《Diseases of the colon and rectum》1997,40(6):706-710
PURPOSE: This study was designed to investigate the role of nitric oxide in neurogenic relaxation of the longitudinal layer
of human rectal smooth muscle. METHODS: Tissue was obtained from the mid rectum of patients undergoing anterior resection
for carcinoma. Adjacent strips of longitudinal muscle were dissected and mounted in organ baths for isometric tension recording.
In preliminary experiments to determine the response of strips to cholinergic, adrenergic, and potential excitatory agonists,
strips were superfused with standard Krebs solution (37±0.5°C; pH, 7.4±0.05). Investigation of inhibitory, nonadrenergic noncholinergic
responses required the addition of 3×10−6 M histamine to induce reproducible and stable tension for five-minute “test” periods, during which electrical field stimulation
(EFS) and additional drugs were applied. In these experiments, strips were superfused with Krebs solution that contained atropine
sulfate (3×10−6 M) and guanethidine (3×10−6 M). RESULTS: The response to cholinergic and adrenergic agonists was typical of nonsphincter specialized gastrointestinal
smooth muscle. EFS elicited frequency-dependent, neurogenic (tetrodotoxin-sensitive) relaxations of precontracted strips,
which were reduced in dose-dependent fashion by addition ofNω-nitro-l-arginine and restored by addition of 3×10
−4
M
l-arginine but not by
d-arginine. Addition of exogenous nitric oxide (sodium nitroprusside) mimicked the relaxant response induced by EFS. CONCLUSION:
Smooth muscle from the longitudinal layer of human rectum receives an intrinsic inhibitory innervation mediated by nitric
oxide.
Supported and financed by the Medical Research Council, United Kingdom.
John Stebbing is in receipt of a Medical Research Council Clinical Training Fellowship.
Read at the meeting of The American Society of Colon and Rectal Surgeons, Seattle, Washington, June 9 to 14, 1996. 相似文献
56.
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59.
Stephen R. Kisely Mike Wise Neil Preston Senia Malmgren Peter Shannon 《Australian and New Zealand journal of public health》2003,27(3):261-263
Objectives: To evaluate a group intervention to help individuals with psychiatric disorder stop smoking.
Method: A waitlist-treatment crossover design. Outcome measures included smoking cessation, motivation to stop, the Fagerstrom Test for Nicotine Dependence (FTND), urinary cotinine and psychiatric symptoms on the General Health Questionnaire.
Results: 38 subjects participated, of whom 19 completed the waitlist and intervention phases. There were no significant differences between subjects and dropouts. During the waitlist period there were no significant changes in tobacco use. At the end of the intervention, almost a quarter had stopped smoking, ( z = -2.24, p =0.02). Subjects also showed significant improvements on state of change, FTND score and urinary cotinine levels. These improvements were maintained at three-month follow-up (n=10). Psychiatric morbidity showed no change.
Conclusions: It is possible to reduce smoking in individuals with psychiatric disorder.
Implications: Larger randomised controlled trials are indicated to determine the relative contributions of nicotine replacement, bupropion and group interventions to smoking cessation in this population. 相似文献
Method: A waitlist-treatment crossover design. Outcome measures included smoking cessation, motivation to stop, the Fagerstrom Test for Nicotine Dependence (FTND), urinary cotinine and psychiatric symptoms on the General Health Questionnaire.
Results: 38 subjects participated, of whom 19 completed the waitlist and intervention phases. There were no significant differences between subjects and dropouts. During the waitlist period there were no significant changes in tobacco use. At the end of the intervention, almost a quarter had stopped smoking, ( z = -2.24, p =0.02). Subjects also showed significant improvements on state of change, FTND score and urinary cotinine levels. These improvements were maintained at three-month follow-up (n=10). Psychiatric morbidity showed no change.
Conclusions: It is possible to reduce smoking in individuals with psychiatric disorder.
Implications: Larger randomised controlled trials are indicated to determine the relative contributions of nicotine replacement, bupropion and group interventions to smoking cessation in this population. 相似文献
60.
Jonathan Cook Neil Prose Mitchell Heflin 《Dermatologic surgery》2003,29(9):1994; author reply 1994-1994; author reply 1995