排序方式: 共有55条查询结果,搜索用时 8 毫秒
41.
Ali Reza Ebrahimzadeh-Bideskan Somaieh Mansouri Mariam Lale Ataei Mehrdad Jahanshahi Mahmoud Hosseini 《Anatomical science international / Japanese Association of Anatomists》2018,93(2):218-230
The effects of tamoxifen and soy on apoptosis of the hippocampus and dentate gyrus of ovariectomized rats after repeated seizures were investigated. Female rats were divided into: (1) Control, (2) Sham, (3) Sham-Tamoxifen (Sham-T), (4) Ovariectomized (OVX), (5) OVX-Tamoxifen (OVX-T), (6)OVX-Soy(OVX-S) and (7) OVX-S-T. The animals in the OVX-S, OVX-T and OVX-S-T groups received soy extract (60 mg/kg; i.p.), tamoxifen (10 mg/kg) or both for 2 weeks before induction of seizures. The animals in these groups additionally received the mentioned treatments before each injection of pentylenetetrazole (PTZ; 40 mg/kg) for 6 days. The animals in the Sham and OVX groups received a vehicle of tamoxifen and soy. A significant decrease in the seizure score and TUNEL-positive neurons was seen in the OVX group compared to the Sham (P < 0.001). The animals in both the OVX-T and OVX-S groups had a significantly higher seizure score as well as number of TUNEL-positive neurons compared to the OVX group (P < 0.01–P < 0.001). Co-treatment of the OVX rats by the extract and tamoxifen decreased the seizure score and number of TUNEL-positive neurons compared to OVX-S (P < 0.001). Treatment of the OVX rats by either soy or tamoxifen increased the seizure score as well as the number of TUNEL-positive neurons in the hippocampal formation. Co-administration of tamoxifen and soy extract inhibited the effects of the soy extract and tamoxifen when they were administered alone. It might be suggested that both soy and tamoxifen have agonistic effects on estrogen receptors by changing the seizure severity. 相似文献
42.
43.
Ataei N Aghamohammadi A Yousefi E Hosseini M Nourijelyani K Tayebi M Khorasani G Chavoshian A Hosseini M Yousefi M 《Pediatric nephrology (Berlin, Germany)》2004,19(2):164-168
Currently there are no blood pressure (BP) nomograms based on local data available in Iran. In order to obtain data on BP distribution in Iranian school children, 8,848 children aged 7–12 years were studied in Tehran. BP was found to increase with age. Both systolic and diastolic BP showed a positive correlation with height and weight in both sexes. The systolic and diastolic BP in boys and girls were not significantly different. As the sample was representative of Iranian school children, reference standard curves were constructed by modeling data using fractional polynomial. The 50th and 95th percentiles of systolic and diastolic BP of Iranian children were compared for each age with the results reported in the study of the Second Task Force. These percentiles were different from the Second Task Force study. Environmental and genetic determinants are likely to be responsible for the differences. The differences show that the use of local BP nomograms is necessary for assessing the BP levels in Iranian children. 相似文献
44.
45.
Keivan Golshiri Ehsan Ataei Ataabadi Eliana C. Portilla Fernandez A. H. Jan Danser Anton J. M. Roks 《Basic & clinical pharmacology & toxicology》2020,127(2):67-80
Among ageing‐related illnesses, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality causing one‐third of all deaths worldwide. Ageing evokes a number of functional, pharmacological and morphological changes in the vasculature, accompanied by a progressive failure of protective and homeostatic mechanisms, resulting in target organ damage. Impaired vasomotor, proliferation, migration, antithrombotic and anti‐inflammatory function in both the endothelial and vascular smooth muscle cells are parts of the vascular ageing phenotype. The endothelium regulates these functions by the release of a wide variety of active molecules including endothelium‐derived relaxing factors such as nitric oxide, prostacyclin (PGI2) and endothelium‐derived hyperpolarization (EDH). During ageing, a functional decay of the nitric oxide pathway takes place. Nitric oxide signals to VSMC and other important cell types for vascular homeostasis through the second messenger cyclic guanosine monophosphate (cGMP). Maintenance of proper cGMP levels is an important goal in sustainment of proper vascular function during ageing. For this purpose, different components can be targeted in this signalling system, and among them, phosphodiesterase‐1 (PDE1) and soluble guanylate cyclase (sGC) are crucial. This review focuses on the role of PDE1 and sGC in conditions that are relevant for vascular ageing. 相似文献
46.
Madani A Kermani N Ataei N Esfahani ST Hajizadeh N Khazaeipour Z Rafiei S 《Pediatric nephrology (Berlin, Germany)》2012,27(1):95-99
Urolithiasis is relatively common in children, and identifiable predisposing factors for stone formation, including metabolic
and structural derangements, can be established in most cases. Vesicoureteral reflux (VUR) is a common cause of kidney stone
formation. The pathophysiological mechanism of urolithiasis in reflux is related to urinary tract infection and urinary stasis,
both of which promote urinary crystal formation, but metabolic causes, such as crystallurias (mostly hypercalciuria), may
also be involved in this process. However, few studies on urinary calcium and uric acid excretion in children with VUR have
been conducted. We have studied the frequency of hypercalciuria and hyperuricosuria in children with VUR and compared the
results with those from a control group. The VUR group comprised 108 children with VUR (19 boys, 89 girls; age range 3 months
to 12 years), and the control group comprised 110 healthy children without any history of reflux or urinary tract infection
(30 boys, 80 girls; age range 2 months to 12 years). Fasting urine was analyzed for the calcium/creatinine (Ca/Cr) and uric
acid/creatinine (UA/Cr) ratios. Hypercalciuria was more frequently diagnosed in the VUR patients than in the control group
(21.3 vs. 3.6%; P = 0.0001). Significant differences between the two groups were also found for the mean Ca/Cr and UA/Cr ratios (P = 0.0001 and P = 0.0001, respectively). No differences were found in the urinary Ca/Cr or UA/Cr ratios related to VUR grading or unilateral/bilateral
VUR in the patient group, with the exception of those for hypercalciuria and mild VUR (P = 0.03). The association of urinary stones and microlithiasis in the VUR group was 29.6%. Our results demonstrate that the
frequency of hypercalciuria and hyperuricosuria was higher in pediatric patients with VUR than in healthy children. Knowing
this relationship, preventive and therapeutic interventions for stone formation in VUR could be greatly expanded. 相似文献
47.
Molouk Hadjibabaie Shirinsadat Badri Sarah Ataei Amir Hossein Moslehi Iman Karimzadeh Ardeshir Ghavamzadeh 《Cancer chemotherapy and pharmacology》2013,71(6):1619-1627
Purpose
To assess the pattern and probable risk factors for moderate and major drug–drug interactions in a referral hematology–oncology ward in Iran.Methods
All patients admitted to hematology–oncology ward of Dr. Shariati Hospital during a 6-month period and received at least two anti-cancer or non-anti-cancer medications simultaneously were included. All being scheduled anti-cancer and non-anti-cancer medications both prescribed and administered during ward stay were considered for drug–drug interaction screening by Lexi-Interact On-Desktop software.Results
One hundred and eighty-five drug–drug interactions with moderate or major severity were detected from 83 patients. Most of drug–drug interactions (69.73 %) were classified as pharmacokinetics. Fluconazole (25.95 %) was the most commonly offending medication in drug–drug interactions. Interaction of sulfamethoxazole-trimethoprim with fluconazole was the most common drug–drug interaction (27.27 %). Vincristine with imatinib was the only identified interaction between two anti-cancer agents. The number of administered medications during ward stay was considered as an independent risk factor for developing a drug–drug interaction.Conclusions
Potential moderate or major drug–drug interactions occur frequently in patients with hematological malignancies or related diseases. Performing larger standard studies are required to assess the real clinical and economical effects of drug–drug interactions on patients with hematological and non-hematological malignancies. 相似文献48.
Elham Mousavi Manoochehr Makvandi Ali Teimoori Angila Ataei Shokouh Ghafari Alireza Samarbaf-Zadeh 《Journal of the Chinese Medical Association》2018,81(3):262-267
Background
Herpes simplex virus type 2 (HSV-2) infectious disease is one of the most common viral sexually transmitted diseases. As regards, vaginal lactobacilli play an important role in protecting host against the urogenital pathogens; here we assessed the potential antiviral activity of Lactobacillus crispatus against HSV-2 infection in vitro.Methods
Both Vero and HeLa cell lines were treated by L. crispatus before, during and after HSV-2 infection. The pre-incubation assay was also performed for the evaluating of virus adsorption by L. crispatus. Virus titer reduction in each stage was determined by a plaque reduction assay.Results
L. crispatus significantly decreased the infectivity of the HSV-2 in initial steps on both cell lines; however, no significant inhibition was ascertained during adsorption and multiplication process. The lactobacilli adhere on Vero cells two-fold stronger than HeLa and subsequently protect the Vero cells nearly 2.5 fold higher than HeLa cell against the virion. Co-incubation of HSV-2 with bacterial cells prior to virus inoculation significantly decreased the virus titer.Conclusion
L. crispatus appears to inhibit the entry of the virus into cells by trapping HSV-2 particles. In addition, formation of L. crispatus microcolonies in the cell surface could block HSV-2 receptors and prevent viral entry to cells in initial infection steps. 相似文献49.
Shojaei H Hashemi A Heidarieh P Feizabadi MM Ataei B Daei Naser A 《Japanese journal of infectious diseases》2011,64(3):234-236
We herein present the third set of documented clinical Mycobacterium setense cases. Three clinically unrelated isolates were identified and characterized using various key conventional and molecular diagnostic tests. Phenotypic and molecular data analysis, particularly 16S rDNA, hsp65, and rpoB sequencing, provided evidence of M. setense involvement in clinical infections in Iranian patients. Our findings may shed light on the capability of this rare Mycobacterium sp. to cause infection in both healthy and immunocompromised patients. 相似文献
50.