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71.
Turton JF Mustafa N Shah J Hampton CV Pike R Kenna DT 《Diagnostic microbiology and infectious disease》2011,70(3):408-411
Achromobacter xylosoxidans is an emerging pathogen among patients with cystic fibrosis. Here we describe a specific PCR for identification of this organism, based on detection of bla(OXA-114-like). Comparison of isolates by pulsed-field gel electrophoresis revealed evidence of cross-infection in some cases, but most patients harbored their own strain. 相似文献
72.
Dubouix-Bourandy A de Ladoucette A Pietri V Mehdi N Benzaquen D Guinand R Gandois JM 《Journal of clinical microbiology》2011,49(12):4225-4230
We evaluated the Xpert MRSA/SA SSTI real-time PCR assay (Cepheid, Sunnyvale, CA) directly on perioperative bone and joint samples. The sensitivity and specificity for detection of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant coagulase-negative Staphylococcus were, respectively, 100% and 98.3%, 100% and 100%, and 100% and 95.3%. The median total test turnaround time was 72 min for PCR versus 79 h for culture. Using these rapid results, appropriate antibiotic treatment could be rapidly initiated. 相似文献
73.
Light and temperature have considerable effect on the degradation of piroxicam in aqueous solutions. The pH and acetate buffer ions also affect the degradation process. The apparent first-order rate constants for the photochemical and thermal degradation of piroxicam have been determined as 2.04-10.01 and 0.86-3.06×10(-3) min(-1), respectively. The first-order plots for the degradation of piroxicam showed good linearity within a range of 20-50% loss of piroxicam at pH 2.0-12.0. The rate-pH profile for the photodegradation of piroxicam is a U-shaped curve and for the thermal degradation a bell-shaped curve in the pH range of 2.0-12.0. The thermal degradation of piroxicam was maximum around pH 6.0. It is increased in the presence of acetate ions but was not affected by citrate and phosphate ions. 相似文献
74.
Bala Basak Oven Ustaalioglu Mahmut Gumus Ahmet Bilici Mesut Seker Faysal Dane Taflan Salepci Tarik Salman Mehmet Aliustaoglu Mehmet Eser Cem Gezen Mustafa Yaylaci Nazim Serdar Turhal 《Medical oncology (Northwood, London, England)》2010,27(2):454-458
Neoadjuvant chemotherapy (NAC) is one of the treatment options for patients with locally advanced breast cancer (LABC). Preoperative chemotherapy potentially may reduce the extent of the surgery and offers the opportunity to assess the chemosensitivity of the tumor in vivo. Herein, we evaluated the results of NAC in Turkish LABC patients. We retrospectively analyzed 73 LABC patients. Anthracycline/taxane-based chemotherapy regimens were administered. Patients were stratified according to age, menopausal status, type of surgery, response to the treatment, histopathological properties, and survival. After 3–6 cycles of chemotherapy, patients were re-staged radiologically and surgery was performed in operable patients. Adjuvant chemotherapy was administered as needed. The median age was 45 (29–93) at the time of diagnosis. Sixteen percentage of patients were younger than 35 years of age and 45.2% were premenopausal. Median follow-up time was 20.2 months. Sixty-seven out of 73 patients responded to therapy (89%). Breast conserving surgery was possible in the 15% of the patients. In histopathological analysis, lymph node invasion was detected in 85%. The estrogen (ER) and progesterone (PR) receptor were positive in 78.1% and c-erb-B2 was positive in 17.5% of patients. The median disease-free survival (DFS) was 44 months (SE: 9; %95 CI: 27.1–60.8), overall survival (OS) was not reached at the time of analysis. Three-year DFS and OS were 58% and 91.9%, respectively. In a multivariate Cox regression analyses; no demographic or pathologic prognostic parameter predicted overall survival. In recent years, NAC in breast cancer has become a viable treatment option for patients with LABC. NAC is not commonly applied in Turkey. The response rate to NAC in Turkish breast cancer patients is encouragingly high. Broader efforts should be made to evaluate breast cancer patients preoperatively at tumor boards for proper treatment sequence. 相似文献
75.
Depolarizing γ‐aminobutyric acid contributes to glutamatergic network rewiring in epilepsy
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Nazim Kourdougli PhD Christophe Pellegrino PhD Juho‐Matti Renko PhD Stanislav Khirug PhD Geneviève Chazal PhD Tiina‐Kaisa Kukko‐Lukjanov PhD Sari E. Lauri PhD Jean‐Luc Gaiarsa PhD Liang Zhou PhD Angélique Peret PhD Eero Castrén PhD Raimo K. Tuominen M.D. PhD Valérie Crépel PhD Claudio Rivera PhD 《Annals of neurology》2017,81(2):251-265
76.
Fraser syndrome is an autosomal recessive disorder in which the life expectancy is <1 year. The main features are cryptophthalmos, ear, nose and skeletal malformations, syndactyly, laryngeal stenosis and malformation of the uro-genital system, lungs, liver and central nervous system (CNS). We report the clinical, laboratory and post-mortem findings of this condition in an elderly woman aged 96 years. She is the oldest known patient with Fraser syndrome. 相似文献
77.
Nazim E. Beyhun Özge U. Soyer Semanur Kuyucu Nihat Sapan Derya U. Altnta Hasan Yüksel Fehmi Y. Anlar Fazil Orhan Ömer Cevit Haluk Çokuras Ayen B. Boz Mehtap Yazcolu Remziye Tanaç Bülent E. ekerel 《Pediatric allergy and immunology》2009,20(1):72-80
Successful management of childhood asthma requires a thorough idea of the economic impact of asthma and its determinants, as policy makers and physicians inevitably influence the outcome. The aim of this study was to define the cost of childhood asthma in Turkey and its determinants. In April 2006, a multi-center, national study was performed where data regarding cost and control levels were collected. Asthmatic children (6–18 yr) with at least a 1-yr follow-up seen during a 1-month period with scheduled or unscheduled visits were included. The survey included a questionnaire-guided interview and retrospective evaluation of files. Cost and its determinants during the last year were analyzed. A total of 618 children from 12 asthma centers were surveyed. The total annual cost of childhood asthma was US$1597.4 ± 236.2 and there was a significant variation in costs between study centers (p < 0.05). Frequent physician visits [odds ratio (95% confidence intervals)] [2.3 (1.6–3.4)], hospitalization [1.9 (1.1–3.3)], asthma severity [1.6 (1.1–2.8)], and school absenteeism due to asthma [1.5 (1.1–2.1)] were major predictors of total annual costs (p < 0.05 for each). The comparable cost of asthma among Turkish children with that reported in developed countries suggests that interventions to decrease the economic burden of pediatric asthma should focus on the cost-effectiveness of anti-allergic household measures and on improving the control levels of asthma. 相似文献
78.
Jean-Louis Herrmann Marie Belloy Raphael Porcher Nancy Simonney Rola Aboutaam Muriel Lebourgeois Joel Gaudelus Laure De LosAngeles Katarina Chadelat Pierre Scheinmann Nicole Beydon Brigitte Fauroux Martine Bingen Mustapha Terki Dominique Barraud Philippe Cruaud Catherine Offredo Agnes Ferroni Patrick Berche Didier Moissenet Hoang Vuthien Catherine Doit Edouard Bingen Philippe Henri Lagrange 《PLoS Clinical Trials》2009,4(1)
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