全文获取类型
收费全文 | 1253篇 |
免费 | 75篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 89篇 |
妇产科学 | 13篇 |
基础医学 | 118篇 |
口腔科学 | 25篇 |
临床医学 | 149篇 |
内科学 | 227篇 |
皮肤病学 | 66篇 |
神经病学 | 31篇 |
特种医学 | 311篇 |
外科学 | 98篇 |
综合类 | 13篇 |
一般理论 | 3篇 |
预防医学 | 69篇 |
眼科学 | 6篇 |
药学 | 31篇 |
肿瘤学 | 87篇 |
出版年
2021年 | 11篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 5篇 |
2016年 | 14篇 |
2015年 | 20篇 |
2014年 | 25篇 |
2013年 | 24篇 |
2012年 | 14篇 |
2011年 | 15篇 |
2010年 | 34篇 |
2009年 | 28篇 |
2008年 | 18篇 |
2007年 | 38篇 |
2006年 | 30篇 |
2005年 | 27篇 |
2004年 | 27篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 17篇 |
2000年 | 14篇 |
1999年 | 27篇 |
1998年 | 97篇 |
1997年 | 71篇 |
1996年 | 77篇 |
1995年 | 56篇 |
1994年 | 56篇 |
1993年 | 61篇 |
1992年 | 20篇 |
1991年 | 12篇 |
1990年 | 23篇 |
1989年 | 51篇 |
1988年 | 36篇 |
1987年 | 46篇 |
1986年 | 24篇 |
1985年 | 37篇 |
1984年 | 27篇 |
1983年 | 17篇 |
1982年 | 22篇 |
1981年 | 23篇 |
1980年 | 29篇 |
1979年 | 8篇 |
1978年 | 17篇 |
1977年 | 18篇 |
1976年 | 20篇 |
1975年 | 17篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1970年 | 2篇 |
排序方式: 共有1339条查询结果,搜索用时 359 毫秒
81.
82.
Bridging bronchus: a rare airway anomaly 总被引:1,自引:0,他引:1
83.
Computed tomography of the pancreas 总被引:2,自引:0,他引:2
84.
Idiopathic chondrolysis of the hip is characterized by pain and limp in adolescence, with progressive loss of articular cartilage space and stiffness of the hip. In our five cases, the best results were obtained in those patients immobilized in a position of function. Those cases in which range-of-motion exercises were carried out resulted in ankylosis in a position of excessive flexion. 相似文献
85.
The binding and processing of monoclonal human IgG1 by cells of a human macrophage-like cell line (U937) 总被引:2,自引:0,他引:2
The goal of these experiments was to assess the relationship between the binding and processing of IgG by Fc-receptor-bearing cells. Cells of the U937 human macrophage-like cell line were incubated with 125I- labeled monomers, dimers, oligomers (composed of 2-4 IgG1 subunits), and HP (heavy polymers composed of 5 or more subunits per polymer) of monoclonal human IgG1 in vitro. Binding was assessed by spinning cells through a layer of phthalate oils. Internalization of IgG1 was assessed by quantitating residual binding to cells after surface-bound IgG was removed by a brief treatment with a solution containing 0.25 M acetic acid and 0.5 M sodium chloride. Catabolism was assessed by measuring the release of radioactive fragments of IgG1, which were not precipitated by 10% trichloroacetic acid. Unstimulated U937 bound about 10,000 molecules per cell of IgG1 monomer, with an equilibrium binding constant (Ka) of 5 X 10(8) M-1. After stimulation with a conditioned medium in vitro, binding per cell was increased 3-7--fold, and the Ka was decreased 2-4--fold. Both unstimulated and stimulated cells internalized and catabolized labeled IgG1 HP, but stimulated cells internalized and digested much more IgG1 HP per cell than unstimulated cells. Both monomers and dimers of IgG1 were internalized and degraded very slowly by stimulated cells, even though both preparations readily bound to cells. In contrast, oligomers and (to an even greater extent) IgG1 HP were internalized and degraded much more rapidly. Internalization of IgG1 HP was markedly inhibited by incubation at 4 degrees C, but not by incubation with a variety of metabolic inhibitors. Catabolism was inhibited by chloroquine and monensin (inhibitors of lysosomal acidification) and by cytochalasin (an inhibitor of microfilament polymerization). Binding to the surface of cells was not markedly inhibited by any agent tested. The capacity of cells to bind labeled IgG1 was markedly reduced by prior incubation in the presence of unlabeled IgG1. This reduction was in part due to the steric blockade of receptors caused by the avid, but reversible, binding of IgG1. In addition, IgG1 oligomers or HP (but not IgG1 monomers or dimers) also caused an irreversible reduction in the number of Fc receptors by a process analogous to receptor down-regulation, as observed in other receptor--ligand systems. 相似文献
86.
Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA),
not observed in adjacent intact tissues. These findings were interpreted as indicating the involvement of mtDNA mutations
in tumorigenesis. Such comparisons, however, ignore an important confounding factor: the monoclonal origin of tumors as opposed
to the highly polyclonal nature of normal tissues. Analysis of recently published data on the incidence of somatic mutations
in nontumor monoclonal cells suggests that, contrary to the prevailing view, the process of tumorigenesis may be accompanied
by active selection against detrimental mtDNA mutations. 相似文献
87.
Postembolic colonic infarction 总被引:12,自引:0,他引:12
88.
89.
Temporal factors and the prevalence of transient exposures at the time of an occupational traumatic hand injury 总被引:1,自引:0,他引:1
Lombardi DA Sorock GS Hauser R Nasca PC Eisen EA Herrick RF Mittleman MA 《Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine》2003,45(8):832-840
Temporal factors and the prevalence of exposure to transient risk factors for occupational traumatic hand injury were analyzed among 1166 subjects participating in a case-crossover study. Temporal factors included time of injury and elapsed time to injury since the start of the work shift. Transient exposures included work equipment, work practice, and worker-related factors. The highest frequency of injury was observed from 08:00 am to 12:00 pm (54.6%), with a peak from 10:00 to 11:00 am (14.9%). The median time into the work shift for injury was 3.5 hours. Subjects injured 2 to 3 hours into their work shift most often reported using a machine, tool, or work material that performed differently than usual (23.9%). These results suggest that acute hand injuries occur earlier in the workday and safety programs should place increased vigilance on these times. 相似文献
90.
Despite the emphasis placed on physicians' lifelong learning, no psychometrically sound instrument has been developed to provide an operational measure of the concept and its components among physicians. The authors designed this study to develop a tool for measuring physician lifelong learning, to identify its underlying components and to assess its psychometric properties. A 37-item questionnaire was developed, based on a review of literature and the results of two pilot studies. Psychometric analyses of the responses of 160 physicians identified 19 items that were included in the Jefferson Scale of Physician Lifelong Learning. Factor analysis of the 19 items showed five meaningful factors that were consistent with the definition and major features of lifelong learning. They were 'need recognition', 'research endeavor', 'self-initiation', 'technical skills' and 'personal motivation'. The method of contrasted groups provided evidence in support of the validity of the five factors. The factors' reliability was assessed by coefficient alpha. It is concluded that lifelong learning is a multifaceted concept, and its operational measure is feasible for evaluating different educational programs and for studying group differences among physicians. 相似文献