全文获取类型
收费全文 | 2919篇 |
免费 | 157篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 227篇 |
妇产科学 | 65篇 |
基础医学 | 348篇 |
口腔科学 | 43篇 |
临床医学 | 223篇 |
内科学 | 485篇 |
皮肤病学 | 68篇 |
神经病学 | 162篇 |
特种医学 | 83篇 |
外科学 | 382篇 |
综合类 | 99篇 |
预防医学 | 135篇 |
眼科学 | 49篇 |
药学 | 367篇 |
中国医学 | 18篇 |
肿瘤学 | 294篇 |
出版年
2023年 | 12篇 |
2022年 | 36篇 |
2021年 | 91篇 |
2020年 | 35篇 |
2019年 | 68篇 |
2018年 | 82篇 |
2017年 | 57篇 |
2016年 | 96篇 |
2015年 | 89篇 |
2014年 | 128篇 |
2013年 | 137篇 |
2012年 | 158篇 |
2011年 | 212篇 |
2010年 | 116篇 |
2009年 | 81篇 |
2008年 | 134篇 |
2007年 | 149篇 |
2006年 | 157篇 |
2005年 | 118篇 |
2004年 | 122篇 |
2003年 | 111篇 |
2002年 | 88篇 |
2001年 | 52篇 |
2000年 | 50篇 |
1999年 | 52篇 |
1998年 | 25篇 |
1997年 | 14篇 |
1996年 | 23篇 |
1995年 | 18篇 |
1994年 | 23篇 |
1992年 | 31篇 |
1991年 | 20篇 |
1990年 | 33篇 |
1989年 | 33篇 |
1988年 | 36篇 |
1987年 | 30篇 |
1986年 | 32篇 |
1985年 | 30篇 |
1984年 | 25篇 |
1983年 | 26篇 |
1981年 | 12篇 |
1979年 | 27篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1974年 | 23篇 |
1972年 | 16篇 |
1971年 | 17篇 |
1970年 | 12篇 |
1968年 | 16篇 |
1967年 | 15篇 |
排序方式: 共有3080条查询结果,搜索用时 31 毫秒
81.
82.
Gabriela Vazquez-Benitez Jay R. Desai Stanley Xu Glenn K. Goodrich Emily B. Schroeder Gregory A. Nichols Jodi Segal Melissa G. Butler Andrew J. Karter John F. Steiner Katherine M. Newton Leo S. Morales Ram D. Pathak Abraham Thomas Kristi Reynolds H. Lester Kirchner Beth Waitzfelder Jennifer Elston Lafata Renuka Adibhatla Zhiyuan Xu Patrick J. O’Connor 《Diabetes care》2015,38(5):905-912
OBJECTIVEThe objective of this study was to assess the incidence of major cardiovascular (CV) hospitalization events and all-cause deaths among adults with diabetes with or without CV disease (CVD) associated with inadequately controlled glycated hemoglobin (A1C), high LDL cholesterol (LDL-C), high blood pressure (BP), and current smoking.RESULTSMean (SD) age at baseline was 59 (14) years; 48% of subjects were female, 45% were white, and 31% had CVD. Mean follow-up was 59 months. Event rates per 100 person-years for adults with diabetes and CVD versus those without CVD were 6.0 vs. 1.7 for MI/ACS, 5.3 vs. 1.5 for stroke, 8.4 vs. 1.2 for HF, 18.1 vs. 40 for all CV events, and 23.5 vs. 5.0 for all-cause mortality. The percentages of CV events and deaths associated with inadequate risk factor control were 11% and 3%, respectively, for those with CVD and 34% and 7%, respectively, for those without CVD.CONCLUSIONSAdditional attention to traditional CV risk factors could yield further substantive reductions in CV events and mortality in adults with diabetes. 相似文献
83.
84.
Narendra Battula Dimitrios Tsapralis David Mayer John Isaac Paolo Muiesan Robert P Sutcliffe Simon Bramhall Darius Mirza Ravi Marudanayagam 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(2):157-163
Objectives: Isolated intrahepatic recurrence is noted in up to 40% of patients following curative liver resection for colorectal liver metastases (CLM). The aims of this study were to analyse the outcomes of repeat hepatectomy for recurrent CLM and to identify factors predicting survival.Methods: Data for all liver resections for CLM carried out at one centre between 1998 and 2011 were analysed.Results: A total of 1027 liver resections were performed for CLM. Of these, 58 were repeat liver resections performed in 53 patients. Median time intervals were 10.5 months between the primary resection and first hepatectomy, and 15.4 months between the first and repeat hepatectomies. The median tumour size was 3.0 cm and the median number of tumours was one. Six patients had a positive margin (R1) resection following first hepatectomy. There were no perioperative deaths. Significant complications included transient liver dysfunction in one and bile leak in two patients. Rates of 1-, 3-and 5-year overall survival following repeat liver resection were 85%, 61% and 52%, respectively, at a median follow-up of 23 months. R1 resection at first hepatectomy (P = 0.002), a shorter time interval between the first and second hepatectomies (P = 0.02) and the presence of extrahepatic disease (P = 0.02) were associated with significantly worse overall survival.Conclusions: Repeat resection of CLM is safe and can achieve longterm survival in carefully selected patients. A preoperative knowledge of poor prognostic factors helps to facilitate better patient selection. 相似文献
85.
Reshma Basu Sunjay Pathak Jyoti Goyal Rajeev Chaudhry Rati B. Goel Anil Barwal 《Indian Journal of Critical Care Medicine》2014,18(12):822-824
CytoSorb® (CytoSorbents Corporation, USA) is a novel sorbent hemoadsorption device for cytokine removal. The aim of this study was to examine the clinical use of CytoSorb® in the management of patient with septic shock. We used this device as an adjuvant to stabilize a young patient with multi-organ failure and severe sepsis with septic shock. A 36-year-old female patient was hospitalized with the complaints of malaise, general body ache, and breathing difficulty and had a medical history of diabetes mellitus type II, hypertension, obstructive sleep apnea, hypothyroidism and morbid obesity. She was diagnosed to have septic shock with multi-organ dysfunction (MODS) and a low perfusion state. CytoSorb® hemoadsorption column was used as an attempt at blood purification. Acute physiology and chronic health evaluation score, MODS score, and sequential organ failure assessment score were measured before and after the device application. CytoSorb application as an adjuvant therapy could be considered in septic shock. 相似文献
86.
87.
Monica Juneja Devendra Mishra Paul S. S. Russell Sheffali Gulati Vaishali Deshmukh Poma Tudu Rajesh Sagar Donald Silberberg Vinod K. Bhutani Jennifer M. Pinto Maureen Durkin Ravindra M. Pandey Mkc Nair Narendra K. Arora 《Indian pediatrics》2014,51(5):359-365
Objective
To develop and validate INCLEN Diagnostic Tool for Autism Spectrum Disorder (INDT-ASD).Design
Diagnostic test evaluation by cross sectional designSetting
Four tertiary pediatric neurology centers in Delhi and Thiruvanthapuram, India.Methods
Children aged 2–9 years were enrolled in the study. INDT-ASD and Childhood Autism Rating Scale (CARS) were administered in a randomly decided sequence by trained psychologist, followed by an expert evaluation by DSM-IV TR diagnostic criteria (gold standard).Main outcome measures
Psychometric parameters of diagnostic accuracy, validity (construct, criterion and convergent) and internal consistency.Results
154 children (110 boys, mean age 64.2 mo) were enrolled. The overall diagnostic accuracy (AUC=0.97, 95% CI 0.93, 0.99; P<0.001) and validity (sensitivity 98%, specificity 95%, positive predictive value 91%, negative predictive value 99%) of INDT-ASD for Autism spectrum disorder were high, taking expert diagnosis using DSM-IV-TR as gold standard. The concordance rate between the INDT-ASD and expert diagnosis for’ ASD group’ was 82.52% [Cohen’s κ=0.89; 95% CI (0.82, 0.97); P=0.001]. The internal consistency of INDT-ASD was 0.96. The convergent validity with CARS (r = 0.73, P= 0.001) and divergent validity with Binet-Kamat Test of intelligence (r = ?0.37; P=0.004) were significantly high. INDT-ASD has a 4-factor structure explaining 85.3% of the variance.Conclusion
INDT-ASD has high diagnostic accuracy, adequate content validity, good internal consistency high criterion validity and high to moderate convergent validity and 4-factor construct validity for diagnosis of Autistm spectrum disorder. 相似文献88.
Background
Wound myiasis in the Indian subcontinent is most commonly caused by old world screw-worm (Chrysomya bezziana).Case Report and management
A 4-yearold malnourished girl presented with full thickness rectal prolapse following acute diarrhea with a large wound and screwworm myiasis of the rectum. Turpentine oil was applied to immobilize the maggots followed by manual extraction. Prolapse was successfully treated by manual reduction followed by strapping of the buttocks.Outcome
Child was thriving well and gained 2 kg weight in follow up after two weeks.Message
Parents should be educated about taking care of prolapsed rectum. 相似文献89.
Aisling M. Lynch Nupur Pathak Varun Pathak Finbarr P. M. O’Harte Peter R. Flatt Nigel Irwin Victor A. Gault 《Diabetologia》2014,57(9):1927-1936
Aims/hypothesis
Modification of the structure of glucagon could provide useful compounds for the potential treatment of obesity-related diabetes.Methods
This study evaluated N-acetyl-glucagon, (d-Ser2)glucagon and an analogue of (d-Ser2)glucagon with the addition of nine amino acids from the C-terminal of exendin(1-39), namely (d-Ser2)glucagon-exe.Results
All analogues were resistant to dipeptidyl peptidase IV degradation. N-Acetyl-glucagon lacked acute insulinotropic effects in BRIN BD11 cells, whereas (d-Ser2)glucagon and (d-Ser2)glucagon-exe evoked significant (p?0.001) insulin release. (d-Ser2)glucagon-exe stimulated cAMP production (p?0.001) in glucagon- and GLP-1-receptor (GLP-1R)-transfected cells but not in glucose-dependent insulinotropic polypeptide-receptor-transfected cells. In normal mice, N-acetyl-glucagon and (d-Ser2)glucagon retained glucagon-like effects of increasing (p?0.001) plasma glucose and insulin levels. (d-Ser2)glucagon-exe was devoid of hyperglycaemic actions but substantially (p?0.001) increased plasma insulin levels. (d-Ser2)glucagon-exe reduced the glycaemic excursion (p?0.01) and increased the insulin secretory (p?0.01) response following a glucose challenge 12 h after administration. Studies in GLP-1R knockout mice confirmed involvement of the GLP-1R pathway in the biological actions of (d-Ser2)glucagon-exe. Twice-daily administration of (d-Ser2)glucagon-exe to high-fat-fed mice for 28 days significantly (p?0.05 to p?0.001) reduced body weight, energy intake and non-fasting glucose levels, as well as increasing insulin concentrations. Glucose tolerance and insulin sensitivity were significantly (p?0.01) improved and energy expenditure, O2 consumption and locomotor activity were (p?0.05 to p?0.001) augmented. The metabolic benefits were accompanied by increases in pancreatic islet number (p?0.001) and area (p?0.05), as well as beta cell area (p?0.05). Beneficial effects were largely retained for 14 days following cessation of treatment.Conclusions/interpretation
This study emphasises the potential of (d-Ser2)glucagon-exe for the treatment of obesity-related diabetes. 相似文献90.