全文获取类型
收费全文 | 454篇 |
免费 | 25篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 34篇 |
妇产科学 | 6篇 |
基础医学 | 37篇 |
口腔科学 | 4篇 |
临床医学 | 25篇 |
内科学 | 156篇 |
皮肤病学 | 2篇 |
神经病学 | 11篇 |
特种医学 | 11篇 |
外科学 | 70篇 |
综合类 | 24篇 |
预防医学 | 57篇 |
眼科学 | 7篇 |
药学 | 21篇 |
中国医学 | 1篇 |
肿瘤学 | 11篇 |
出版年
2021年 | 9篇 |
2020年 | 3篇 |
2019年 | 10篇 |
2018年 | 8篇 |
2017年 | 11篇 |
2016年 | 6篇 |
2015年 | 9篇 |
2014年 | 9篇 |
2013年 | 17篇 |
2012年 | 25篇 |
2011年 | 21篇 |
2010年 | 12篇 |
2009年 | 14篇 |
2008年 | 17篇 |
2007年 | 18篇 |
2006年 | 26篇 |
2005年 | 20篇 |
2004年 | 16篇 |
2003年 | 13篇 |
2002年 | 14篇 |
2001年 | 15篇 |
2000年 | 16篇 |
1999年 | 7篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1995年 | 3篇 |
1994年 | 3篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 11篇 |
1989年 | 16篇 |
1988年 | 4篇 |
1987年 | 8篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1968年 | 7篇 |
1967年 | 2篇 |
1966年 | 3篇 |
1963年 | 4篇 |
排序方式: 共有480条查询结果,搜索用时 31 毫秒
101.
Objective To study the neurotic manifestations in thalassemic adolescents as a consequence of long-term illness.
Methods From July 2003, thirty six thalassemic adolescents and forty normal adolescents were selected with age ranging from 13 to
18, and with same socio economic status and family, background. Middlesex Hospital Questionnaire by Crown and Crisp [1996]
was administered and Mann Whiteny ‘U’ test was employed to measure free-floating anxiety, phobia, somatic anxiety, obsession,
depression, hysteria and total neuroticism score. An interview was conducted along with the questionnaire to detect the problems
in depth. Parents of thalassemic adolescents were interviewed subsequently to realize the behavioral problems existing along
with neuroticism.
Results Thirty-six of thalassemic and all forty normal adolescents returned the questionnaires. The responses suggest a marked difference
in total neuroticism score and all other variables except that of hysteria. The interview on parents of thalassemic adolescents
exposed various behavioral problems in these adolescents.
Conclusions Thalassemic adolescents were having higher scores in neuroticism. Some behavioral problems are also found to exist along with
neurotic manifestations. There remains a need, to improve the management of thalassemia in terms of psychological aspects
in order to improve the mental health of this group. 相似文献
102.
Shilong Li Rangaprasad Sarangarajan Tomi Jun Yu-Han Kao Zichen Wang Ke Hao Emilio Schadt Michael A. Kiebish Elder Granger Niven R. Narain Rong Chen Eric E. Schadt Li Li 《The Journal of clinical investigation》2021,131(19)
BACKGROUNDThe angiotensin-converting enzyme (ACE) D allele is more prevalent among African Americans compared with other races and ethnicities and has previously been associated with severe coronavirus disease 2019 (COVID-19) pathogenesis through excessive ACE1 activity. ACE inhibitors/angiotensin receptor blockers (ACE-I/ARB) may counteract this mechanism, but their association with COVID-19 outcomes has not been specifically tested in the African American population.METHODSWe identified 6218 patients who were admitted into Mount Sinai hospitals with COVID-19 between February 24 and May 31, 2020, in New York City. We evaluated whether the outpatient and in-hospital use of ACE-I/ARB is associated with COVID-19 in-hospital mortality in an African American compared with non–African American population.RESULTSOf the 6218 patients with COVID-19, 1138 (18.3%) were ACE-I/ARB users. In a multivariate logistic regression model, ACE-I/ARB use was independently associated with a reduced risk of in-hospital mortality in the entire population (OR, 0.655; 95% CI, 0.505–0.850; P = 0.001), African American population (OR, 0.44; 95% CI, 0.249–0.779; P = 0.005), and non–African American population (OR, 0.748, 95% CI, 0.553–1.012, P = 0.06). In the African American population, in-hospital use of ACE-I/ARB was associated with improved mortality (OR, 0.378; 95% CI, 0.188–0.766; P = 0.006), whereas outpatient use was not (OR, 0.889; 95% CI, 0.375–2.158; P = 0.812). When analyzing each medication class separately, ARB in-hospital use was significantly associated with reduced in-hospital mortality in the African American population (OR, 0.196; 95% CI, 0.074–0.516; P = 0.001), whereas ACE-I use was not associated with impact on mortality in any population.CONCLUSIONIn-hospital use of ARB was associated with a significant reduction in in-hospital mortality among COVID-19–positive African American patients.FUNDINGNone. 相似文献
103.
Sunil Narain Bobby Batra Sunil Ninan Abraham L. S. Arya 《Indian journal of pediatrics》2001,68(9):897-899
We report here a case of congenital syphilis presenting in a newborn infant at birth. A negative infant VDRL test, pseudoparesis
and more notably, joint swellings (arthritis) were features seen uncommonly. Florid skeletal involvement, which is rarely
seen in the early neonatal period, prompted us to draw attention to the varied presentation of this disease, rightly referred
to as the “master masquerader”. 相似文献
104.
OBJECTIVE: To determine whether vestibulectomy is an effective long-term treatment and investigate the levels of patient satisfaction in women with localized provoked vulvodynia, and to provide long-term follow-up data from a cohort of women whose short-term success rates have been published previously. STUDY DESIGN: A retrospective case note review of 110 women with localized provoked vulvodynia and follow-up patient questionnaire. Patients were asked to quantify their pain scores before surgery, at 2 months after surgery and 1 year after surgery and score their satisfaction levels. RESULTS: Mean pain scores continued to improve throughout the first postoperative year. The mean score was 9.17 preoperatively, 5.24 at 2 months after surgery and 2.48 at 1 year after surgery. Eighty-three percent of patients would recommend the procedure as effective treatment of localized provoked vulvodynia. The overall mean satisfaction score was 7.96, and long-term success appears to be reflected by short-term results. CONCLUSION: Vestibulectomy is an effective long-term treatment for women with provoked localized vulvodynia; the procedure is associated with high levels of patient satisfaction and low complication rates. Shortterm success appears to be a good indicator of long-term improvement, and improve- ment continues throughout the first postoperative year. 相似文献
105.
Satya Narain 《Journal of maxillofacial and oral surgery》2015,14(1):7-10
Nasolabial cyst also known as Klestadt’s cyst is relatively rare soft tissue lesion of nasal alar region. It is nonodontogenic in origin and characterized by its extra osseous location. This paper documents clinical presentation, differential diagnosis and surgical management of nasolabial cyst in 25 years old woman. 相似文献
106.
107.
108.
Somnath Ghosh Amit Kumar Badri Narain Pandey Kaushala Prasad Mishra 《Journal of environmental pathology, toxicology and oncology》2007,26(4):255-261
Although the kidneys are the main target organs for uranium (U) toxicity, recent studies have shown that U can cross the blood-brain barrier to accumulate in the brain. Uranyl nitrate (U-238)induced oxidative damage was investigated in brain and bone of Wistar rats after intraperitoneal injection of uranyl nitrate at acute doses either nephrotoxic (576 microg of U/kg body weight) or subnephrotoxic (144 microg U/kg body weight). The health effects of U administration at 576 microg of U/kg body weight were seen in terms of decrease in food intake and no gain in body weight compared to respective controls. These alterations were correlated with increased lipid peroxidation as measured by thiobarbituric acid reactive substances in rat brain and bone. However, at lower dosage of U (144 microg U/kg body weight), no significant lipid peroxidation was observed in brain and bone. Histological examination of U-treated (576 microg of U/kg body weight) rat brain tissues showed marked and diffuse cystic degeneration and a similar pattern in histological alterations was observed in kidneys in treated animals; whereas no significant histological change was observed in rat brains and kidney treated with a lower dose of U (144 microg U/kg body weight). It is concluded that administration of U at an acute nephrotoxic dose caused oxidative stress in brain and bone manifested as lipid peroxidation and histopathological damage. 相似文献
109.
K Shukla J P Narain P Puri A Gupta R L Bijlani S C Mahapatra M G Karmarkar 《Indian journal of physiology and pharmacology》1991,35(4):249-254
The postprandial glycaemic response to maize (Zea mays), bajra (Pennisetum typhoideum) and barley (Hordeum vulgare) was studied in a pool of 18 healthy volunteers and 14 patients having non-insulin-dependent diabetes mellitus (NIDDM). In response to maize, none of the variables examined was significantly different as compared to white bread. The glycaemic response to bajra was significantly lower than that to white bread in healthy subjects, but the two responses were indistinguishable in NIDDM subjects. The insulinaemic responses to bajra and white break were not significantly different in either group of subjects. The glycaemic response to barley was significantly lower than that to white bread in both groups of subjects. But the insulinaemic response to barley was significantly lower than that to white bread only in healthy subjects. In NIDDM subjects, there was a tendency for the response to barley to be higher than that to white bread 0.5 h after ingestion. Barley, with a low glycaemic index (68.7 in healthy and 53.4 in NIDDM subjects) and a high insulinaemic index (105.2) in NIDDM subjects seems to mobilize insulin in NIDDM. This makes it a specially suitable cereal for diabetes mellitus. 相似文献
110.
Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia 总被引:1,自引:0,他引:1
D Laurin H Jacques S Moorjani F H Steinke C Gagné D Brun P J Lupien 《The American journal of clinical nutrition》1991,54(1):98-103
The effects of soy protein (35% of protein energy) given as a beverage and those of cow-milk proteins were investigated on plasma lipoprotein concentrations in children with familial hypercholesterolemia (FH). Subjects were randomly assigned to either the soy-protein or cow-milk-protein experimental period, with subsequent crossover after a washout period, each period lasting 4 wk. Diets were planned to provide 20% energy as protein, 28% as fat (polyunsaturated:monounsaturated:saturated fatty acids, 1:3:3) and less than 200 mg cholesterol/d. No changes were observed in either plasma cholesterol, low-density-lipoprotein cholesterol, or apolipoprotein concentrations. However, the soy beverage significantly reduced the concentrations of triglyceride and very-low-density-lipoprotein cholesterol (P less than 0.05) and significantly increased the concentrations of high-density-lipoprotein cholesterol (HDL-C) and HDL3-C (P less than 0.04 and P less than 0.03, respectively). These results indicate that the administration of soy protein may induce clinically beneficial effects in children with FH. 相似文献