全文获取类型
收费全文 | 5811篇 |
免费 | 252篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 94篇 |
妇产科学 | 24篇 |
基础医学 | 715篇 |
口腔科学 | 73篇 |
临床医学 | 352篇 |
内科学 | 1357篇 |
皮肤病学 | 128篇 |
神经病学 | 396篇 |
特种医学 | 122篇 |
外科学 | 1193篇 |
综合类 | 18篇 |
预防医学 | 179篇 |
眼科学 | 195篇 |
药学 | 443篇 |
中国医学 | 1篇 |
肿瘤学 | 701篇 |
出版年
2022年 | 46篇 |
2021年 | 58篇 |
2020年 | 44篇 |
2019年 | 59篇 |
2018年 | 84篇 |
2017年 | 82篇 |
2016年 | 93篇 |
2015年 | 107篇 |
2014年 | 144篇 |
2013年 | 157篇 |
2012年 | 222篇 |
2011年 | 273篇 |
2010年 | 176篇 |
2009年 | 134篇 |
2008年 | 235篇 |
2007年 | 259篇 |
2006年 | 271篇 |
2005年 | 307篇 |
2004年 | 277篇 |
2003年 | 288篇 |
2002年 | 291篇 |
2001年 | 200篇 |
2000年 | 223篇 |
1999年 | 206篇 |
1998年 | 64篇 |
1997年 | 63篇 |
1996年 | 48篇 |
1995年 | 52篇 |
1994年 | 56篇 |
1993年 | 45篇 |
1992年 | 143篇 |
1991年 | 130篇 |
1990年 | 116篇 |
1989年 | 104篇 |
1988年 | 115篇 |
1987年 | 89篇 |
1986年 | 102篇 |
1985年 | 109篇 |
1984年 | 56篇 |
1983年 | 50篇 |
1982年 | 35篇 |
1979年 | 39篇 |
1977年 | 35篇 |
1974年 | 29篇 |
1973年 | 27篇 |
1972年 | 29篇 |
1971年 | 27篇 |
1969年 | 27篇 |
1967年 | 33篇 |
1966年 | 27篇 |
排序方式: 共有6078条查询结果,搜索用时 703 毫秒
21.
Five latissimus dorsi musculocutaneous flaps (LD flap) were used for reconstruction with prostheses after resection of tumors between 1984 and 1991 in our hospital. Bony structures were reconstructed with prostheses and in three cases autoclaved autobone grafts were also needed. The prostheses and adjacent grafts were then wrapped by the LD flaps. Tumor sites included one humerus, two thighs, and two knees. All but one case healed primarily. The sole case of infection was successfully treated with debridement and irrigation. Due to the LD flaps' plentiful blood supply, we believe infection of the prosthetics can be avoided and good clinical results can be achieved using the flap with autoclaved autograft prosthetic composite reconstruction. © 1994 Wiley-Liss, Inc. 相似文献
22.
Tomohiro Kondo Kazuhiro Sentani Naohide Oue Kazuhiro Yoshida Hirofumi Nakayama Wataru Yasui 《Pathobiology》2004,71(1):19-25
OBJECTIVES: RHOC, a member of the RAS-related small GTPase protein family, regulates cytoskeletal structures and has the potential to transform cultured cells. It has recently been reported that RHOC contributes to the metastatic phenotype of melanoma cells. The purpose of this study was to clarify its biological relevance to gastric carcinogenesis and metastasis. METHODS: We examined the expression of RHOC by quantitative RT-PCR in 51 cases of gastric carcinoma tissues from prior surgical cases (intestinal type: 24 cases, diffuse type: 27 cases) and in 8 gastric carcinoma cell lines. RESULTS: RHOC expression levels in primary tumors were significantly higher in cases with metastasis than in those without metastasis (p = 0.0202; Mann-Whitney U test). RHOC expression levels in primary tumor and their metastatic tumors were significantly higher than their corresponding nonneoplastic mucosa (p = 0.0357, and 0.0173, respectively; Wilcoxon signed rank test). RHOC mRNA expression was confirmed in the gastric carcinoma cell lines. CONCLUSION: Our findings suggest that elevated expression of the RHOC gene may be involved in the metastasis of gastric carcinomas and may be a good genetic marker for the prediction of a metastatic potential. 相似文献
23.
Katsunobu Kawahara Shinji Akamine Takao Takahashi Akihiro Nakamura Hiroyuki Kusano Tohru Nakagoe Takayuki Nakazaki Hiroyoshi Ayabe Masao Tomita 《Surgery today》1994,24(12):1101-1103
We report herein the case of a 75-year-old man who developed anal canal metastasis from squamous cell carcinoma of the lung. Initially, he underwent a right middle and lower lobectomy combined with left atrial wall resection under cardiopulmonary bypass. He presented 3 months later with an anal polyp which had prolapsed and bled, for which he underwent a transanal polypectomy. Histologically, the polyp was classified as squamous cell carcinoma and considered to be a metastasis from the primary lung cancer. He is presently well with no signs of recurrence 9 months after his initial operation. To our knowledge, there has been no other case of anal metastasis from lung cancer ever reported. 相似文献
24.
25.
The authors prospectively studied changes in the optic disc and visual field associated with intraocular pressure (IOP) reduction for one year after surgery in 12 primary open-angle glaucoma eyes of 7 patients who underwent trabeculectomy because of elevated IOP despite maximum tolerable medical therapy and whose cup volume was demonstrated to be decreased at 3 or 6 months after surgery. Topographic parameters including C/D ratio, rim area and cup volume were determined by the Optic Nerve Head Analyzer plus (Rodenstock). The 30-2 central threshold field was obtained with a Humphrey Field Analyzer at the same time. Mean deviation (MD), corrected pattern standard deviation (CPSD) and total deviation (TD) were used to evaluate visual field changes. Significant improvement of C/D ratio, rim area and cup volume and significant IOP reduction were noted at 1 year after surgery as compared with preoperative baseline value (p less than 0.01). Also the MD was significantly decreased at 1 year after surgery, compared with the preoperative baseline value (p less than 0.05). There was a significant negative correlation between the preoperative MD and the percent change of the MD at 1 year after surgery (r = -0.80, p less than 0.01). Our results suggest that the decrease of optic disc cupping can persist over one year after surgery and that the early visual field defects in glaucoma eyes can gradually improve in association with the decrease of cupping. 相似文献
26.
M Tsunakawa O Tenmyo K Tomita N Naruse C Kotake T Miyaki M Konishi T Oki 《The Journal of antibiotics》1992,45(2):180-188
A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus. 相似文献
27.
Itsuro Tomita Katsuya Sato Susumu Shirabe Kunihiko Nagasato Akira Satoh Mitsuhiro Tsujihata 《Clinical neurology》2004,44(3):182-186
Serial DWIs were performed in a patient with CJD who developed symptoms acutely and progressed rapidly. DWI discloed an increased signal in the frontal and parietal inner cortical areas, and in the caudate nuclei and putamina 20 days after the onset of symptoms. T2-weighted images showed only signal abnormality in the caudate nuclei and putamina, but not in the cerebral cortex. In the CSF obtained 15 days after the onset of symptoms, total tau protein was markedly elevated and 14-3-3 protein was positive. Measurement of these proteins are highly specific and sensitive for the diagnosis of CJD, but not available as a rapid routine examination at present. DWI is not specific, but useful for making the diagnosis of CJD in the early stage of the disease. 相似文献
28.
Yusuke Ando Takahiro Nishida Shigeki Morita Munetaka Masuda Yukihiro Tomita Ryuji Tominaga 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2006,54(8):335-337
Infective endocarditis of the mitral area accompanied by anorexia nervosa is extremely rare. A 34-year-old Japanese woman presented with high fever and a heart murmur that had developed over the previous 2-month period. Echocardiography revealed mitral regurgitation and vegetation attached to the anterior mitral leaflet, which had markedly prolapsed to the left atrium. We removed the vegetation with a small part of the anterior mitral leaflet and successfully repaired the mitral valve. The patient showed good recovery, and the mitral regurgitation and left ventricular chamber size had satisfactorily decreased at 2 months after the operation. 相似文献
29.
Mitsuru Masaki Tadashi Kuroda Naoki Hosen Hisao Hirota Kazuo Terai Yuichi Oshima Yoshikazu Nakaoka Shoko Sugiyama Ryusuke Kimura Satoshi Yoshihara Manabu Kawakami Norishige Iizuka Yasuhiko Tomita Hiroyasu Ogawa Ichiro Kawase Keiko Yamauchi-Takihara 《Journal of the American Society of Echocardiography》2004,17(4):397-398
A 57-year-old man with a history of renal cell carcinoma presented with presyncope. He underwent nephrectomy years earlier followed by HLA-matched allogeneic peripheral-blood stem-cell transplantation. Echocardiographic investigation revealed a solitary right ventricle mass without contiguous vena caval or right atrial involvement. The mass was pathologically confirmed to be metastatic carcinoma in the right ventricular cavity. This case highlights the need to consider an underlying neoplastic syndrome in patients presenting isolated right ventricle mass by echocardiography. 相似文献
30.
Endogenous bone-marrow-derived stem cells contribute only a small proportion of regenerated myocardium in the acute infarction model. 总被引:6,自引:0,他引:6
Shinya Fukuhara Shinji Tomita Takeshi Nakatani Chikao Yutani Soichiro Kitamura 《The Journal of heart and lung transplantation》2005,24(1):67-72
BACKGROUND: Our recent study showed that granulocyte-colony stimulating factor (G-CSF) promoted bone-marrow cells (BMC) to migrate into the infarcted heart and that they differentiated into cardiomyocytes. However, we still do not know to what degree bone-marrow-derived cardiomyocytes contribute to myocardial regeneration after injury. In this study, we verified the proportional contribution of cells from bone marrow (BM) and from non-bone marrow (n-BM) in regenerating neomyocardium after myocardial infarction. METHODS: Eight C57BL/6 mice were irradiated (900 cGy), and green fluorescent protein (GFP) mouse-derived BMCs (GFP-BMC, 1 x 10(6) cells) were injected. Four weeks later, the left descending coronary artery was ligated. Recombinant human G-CSF (200 microg/kg/day, 8 days) was injected. At 4 weeks after ligation, hearts were fixed for histology. We calculated the proportions of cardiomyocytes derived from BM and n-BM after taking the chimeric rate into consideration. RESULTS: The chimeric rate was 54.6% +/- 5.9%. At the infarcted border area, the total cell number was 1000.3 +/- 56.5/mm(2), and mobilized BM-derived GFP-BMC was 103.3 +/- 13.1/mm(2). After compensation with the chimeric rate, we found BM-derived troponin I-positive cells at 23.9 +/- 4.1/mm(2), nestin-positive cells at 12.9 +/- 2.6/mm(2), and Ki67-positive cells at 18.3 +/- 2.6/mm(2), respectively. We found significant differences in the contribution of troponin I-(6.7% +/- 1.7% vs 93.3% +/- 1.7%), nestin- (2.4 +/- 0.5 vs 97.6 +/- 0.5), and Ki67-positive (3.9 +/- 1.0 vs 96.1 +/- 1.0) cells derived from BM and n-BM. CONCLUSIONS: Bone marrow was one of the origins of regenerated cardiomyocytes; however, the contribution of cells from BM was very small compared with those of n-BM origin in the infarction model. 相似文献