A regenerative method for the surgical treatment of paronychia by applying a buried suture

The suggested regenerative method for surgical treatment of panaritium with placing a blind suture at the period of formation of lipoblasts (at day 3 after the operative intervention) permits to prevent development of purulent complications, accelerate the process of wound healing within a period approximating that in wound healing by primary intention with complete restoration of the hand and digit function.     

Reproductive Toxicity of Sulfamethazine in Swiss CD-1 Mice during Continuous Breeding

Sulfamethazine (SMZ) was evaluated for reproductive toxicityin Swiss CD-1 mice using a continuous breeding protocol. SMZwas administered in the diet at 0, 0.25, 0.5, or 1% (w/w), whichrepresented an average daily intake of 0, 313, 625, or 1250mg SMZ/kg/day, respectively. Exposure of F0 male and femalemice to 1% SMZ for 126 days resulted in a significant decreasein the mean number of live pups per litter and the number oflitters produced (task 2); the percentage pups born alive to1% SMZ females showed a nonsignificant decrease versus controlfemales. The effects on fertility were rapid to onset (1 to4 weeks) and cumulative in nature. F0 male and female body weightswere slightly depressed from 3 weeks to the end of the study.The crossover mating trial (task 3) revealed that the adverseeffect on ferility involved both treated partners in that littersize decreased when either 1% SMZ males were bred to controlfemales or 1% SMZ females were mated with control males. Afterapproximately 155 days of exposure of F0 mice to 1% SMZ, theterminal body weight of 1% SMZ females was significantly decreasedand that of 1% SMZ males showed a nonsignificant decrease. Inaddition, the liver weight to body weight ratio of the maleswas increased. Further, the prostate and seminal vesicle weightto body weight ratios were decreased in 1% SMZ males relativeto control males. No treatment-related gross or histopathologicallesions were noted for the pituitary or reproductive organsof either sex. Sperm assessment indicated no significant differencein the epididymal sperm concentration or percentage motile orabnormal sperm. In conclusion, SMZ was found to be a reproductivetoxicant in the male and female Swiss CD-1 mouse, albeit atrelatively high dietary intake (1250 mg/kg/day), and in thepresence of mild systemic toxicity.     

A study of the spinal fluid flow by magnetic resonance imaging

The study was undertaken to examine the potentialities of new MRI techniques (MR-myelocysternoventriculography and phasic contrast-enhanced MRI with reference to a cardiac cycle) in visualizing the spinal fluid system and flow in different groups of neurosurgical patients. MR-myelocysternoventriculography was based on the sequences of SSFP-3D (Signa, GE, 1.5 T) and PSIF-3D (Magnetom 42SP, Siemens, 1.0 T). These regimens were applied to obtain highly T2*-weighed images. These techniques were used in 280 patients. Phasic contrast-enhanced MRI with reference to a cardiac cycle was performed in the axial (through the aqueduct of the cerebrum) and sagittal projects (CINE-2D mode, Signa GE). This technique was employed to study 30 patients and 5 healthy volunteers. MRI-cysternography based on SSFP-3D- and PSIF-3D sequences is recommended as the method of choice in evaluating the 3rd ventriculostoma and, in combination with spiral computed tomography, in detecting fistulas of the base of the skull. Phasic contrast-enhanced MRI with reference to a cardiac cycle yielded the values of spinal fluid flow through the aqueduct of the cerebrum in health: Vsyst max = 4.1 +/- 1.3 cm/sec; Vsyst mean = 2.5 +/- 1.4 cm/sec; Vdiast max = 3.4 +/- 1.5 cm/sec; Vdist mean = 2.5 +/- 1.7 cm/sec (N = 5). The prospect of the technique is to develop recommendations and to predict prognosis while making bypass surgery for ventriculostomas and cystostomas.     

The ways of the efficacy raising in surgical treatment of patients with colonic cancer

The indications extension for the radical surgical intervention conduction in elderly and senile patients and with locally spreading colonic cancer had promoted the result of their treatment improvement.