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排序方式: 共有9085条查询结果,搜索用时 15 毫秒
31.
Tartakovskiĭ IS 《Vestnik Rossi?sko? akademii meditsinskikh nauk / Rossi?skaia akademiia meditsinskikh nauk》2001,(11):11-14
The paper summarizes the results of 25-year study of Legionnaires' disease (Legionnaire's bacillus infection) in its epidemiology, diagnosis, and prevention, the taxonomy and biology of the causative organism. Emphasis is laid on the contribution of the Russian school of investigators in studying this problem. Despite the intensive efforts in investigating the infection and its causative organism, there are still many problems in predicting and preventing the epidemics of Legionnaires' disease, which annually occur in different countries of the world. Legionnaires' disease is a typical example of technogenic infections: active industrial and domestic uses of closed water circulating systems in industry and aerosol sources promote the spread of the infection caused by Legionnaire's bacillus and make its control in these systems. Despite the introduction of current immunological and molecular genetic methods, diagnosis is effective only for L. pneumophila, serogroup 1. The sensitivity and specificity of methods for diagnosis and identification for other 15 L. pneumophila serogroups and 41 species of L. bacilli are far from being perfect. L. bacilli are also a most popular object for studying the biochemical and genetic aspects of its intracellular parasitism. 相似文献
32.
The aim of this work was to demonstrate the role of interferon alpha (IA) in apoptosis control of cells of hypothalamohypophysial adrenocortical system (HHAS) in young and old mice under conditions of hyperoxia. The increase of functional activity of neurosecretory cells of hypothalamic paraventricular nucleus in old mice treated with IA was demonstrated, while no effect was found in young mice. This differences could be associated with aging changes in HHAS in intact old animals. Oxidative stress caused an increase in the number of cells synthesizing proapoptotic c-fos protein in paraventricular nucleus of mice of both age groups. However, the protective action of IA against the stress is expressed more actively and in more early stage of apoptosis in young mice. Thus, the degree of IA participation in the control of programmed cell death of hypothalamic cells depends on the age of the animal. In the adrenal zona fasciculata of young mice the number of apoptotic cells was significantly increased after IA administration while after hyperoxia or its combination with IA it remained at control level. In the adrenal gland of old mice the proportion of apoptotic cells was not different from that found in young mice and remained unchanged after all experimental challenges. 相似文献
33.
The review examines the current data on the cellular and tissue mechanisms of scar formation in the liver. On the basis of the analysis of the literature, authors conclude that to minimize the destructive processes in the liver, the most advisable and promising method during the operations on this organ is the use of laser surgical devices. However, the problems of the selection of the optimal regimes of laser radiation and of the methods of conducting these operations to promote reliable and rapid healing of postoperative wound of the liver. 相似文献
34.
Yinshi Ren Zhuo Deng Vishal Gokani Michael Kutschke Thomas Wesley Mitchell Olumide Aruwajoye Naga Suresh Adapala Nobuhiro Kamiya Yousef Abu-Amer Harry KW Kim 《Journal of bone and mineral research》2021,36(2):357-368
Legg-Calvé-Perthes disease (LCPD) is a juvenile form of ischemic femoral head osteonecrosis, which produces chronic hip synovitis, permanent femoral head deformity, and premature osteoarthritis. Currently, there is no medical therapy for LCPD. Interleukin-6 (IL-6) is significantly elevated in the synovial fluid of patients with LCPD. We hypothesize that IL-6 elevation promotes chronic hip synovitis and impairs bone healing after ischemic osteonecrosis. We set out to test if anti-IL-6 therapy using tocilizumab can decrease hip synovitis and improve bone healing in the piglet model of LCPD. Fourteen piglets were surgically induced with ischemic osteonecrosis and assigned to two groups: the no treatment group (n = 7) and the tocilizumab group (15 to 20 mg/kg, biweekly intravenous injection, n = 7). All animals were euthanized 8 weeks after the induction of osteonecrosis. Hip synovium and femoral heads were assessed for hip synovitis and bone healing using histology, micro-CT, and histomorphometry. The mean hip synovitis score and the number of synovial macrophages and vessels were significantly lower in the tocilizumab group compared with the no treatment group (p < .0001, p = .01, and p < .01, respectively). Micro-CT analysis of the femoral heads showed a significantly higher bone volume in the tocilizumab group compared with the no treatment group (p = .02). The histologic assessment revealed a significantly lower number of osteoclasts per bone surface (p < .001) in the tocilizumab group compared with the no treatment group. Moreover, fluorochrome labeling showed a significantly higher percent of mineralizing bone surface (p < .01), bone formation rate per bone surface (p < .01), and mineral apposition rate (p = .04) in the tocilizumab group. Taken together, tocilizumab therapy decreased hip synovitis and osteoclastic bone resorption and increased new bone formation after ischemic osteonecrosis. This study provides preclinical evidence that tocilizumab decreases synovitis and improves bone healing in a large animal model of LCPD. © 2020 American Society for Bone and Mineral Research (ASBMR). 相似文献
35.
Immunohistochemical profile of endometrioid adenocarcinoma of the uterus: ER, PR, HER-2, Ki-67 and their prognostic value 总被引:6,自引:0,他引:6
76 endometrioid adenocarcinomas of the uterine body were studied. Expression of the above markers is of essential value together with metastatic involvement of regional lymph nodes, stage of the disease and pathogenetic variant for determining prognosis of carcinoma aggressiveness and disease outcome. Positive hormonal-receptor status of the tumor is characterized by well-differentiated tumor cells, small depth of invasion, rare metastases to regional lymph nodes and higher survival (5 year--81%) of patients comparing with cases where ER and PR were not determined (53%). On the contrary, overexpression of oncoprotein HER-2 and Ki-67 higher than median (42%) was associated with high tumor aggression resulting finally in a significant fall in the survival (from 75% to 58% and from 79% to 60%, respectively). Combination of HER-2 overexpression with a high level of Ki-67 is particularly unfavourable (5-year survival--43%). 相似文献
36.
Merrill S. Kies David Grinblatt Melissa Runge-Morris Richard Blough Arletrice Watkins Sam Taylor IV 《Investigational new drugs》1994,12(1):45-47
The Illinois Cancer Center entered 25 patients on a phase II trial of intravenous melphalan treating patients with recurrent, metastatic or locally advanced and inoperable squamous cell carcinoma of the head and neck. All patients had bi-dimensionally measurable disease, at least a sixty day life expectancy, and adequate performance status (ECOG scale 2). All patients except one had received prior radiotherapy, chemotherapy or both. Melphalan dosage was 30 mg/m2 every three weeks. Twenty-four patients were evaluable for response. One patient with laryngeal carcinoma had a clinical complete response of a nodal metastasis. Four patients had stabilization of disease for one to three months. There was formidable toxicity, including neutropenia (ANC < 1000/l 36%), and thrombocytopenia (< 50,000/l 32%). There were no drug-related deaths. Melphalan administered intravenously does not appear to be efficacious therapy in patients with previously treated advanced head and neck squamous carcinomas. 相似文献
37.
Blinov NN Kozlovskiĭ EB Luzin SI Pervov AIu Sonin AF Plutov IG Rodin VI 《Meditsinskaia tekhnika》1999,(5):24-26
The paper deals with the specific features of X-ray diagnostic units that have no screen-filming device for film X-ray study, with the requirements for hardware and software of these units. It gives data on specific systems for digital X-ray study. 相似文献
38.
The prospects for developing a new noninvasive medical diagnostic technique, such as optical (laser) tomography of biological tissues largely depend on the feasibility of designing an adequate mathematical model for the reconstruction of images of the spatial structure of objects that are in the highly scattering medium (HSM). The basic difficulty is that it is necessary to effectively describe the physical properties and the propagation pattern of photons of different types in such a medium. This review considers methods for describing the distribution of laser ultrashort pulses in HSM with particular emphasis on a new nonstationary two-flux model of radiation transfer. 相似文献
39.
40.