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排序方式: 共有1399条查询结果,搜索用时 15 毫秒
31.
Collettini Federico Schreiber Nadja Schnapauff Dirk Denecke Timm Wust Peter Schott Eckart Hamm Bernd Gebauer Bernhard 《Strahlentherapie und Onkologie》2015,191(5):405-412
Strahlentherapie und Onkologie - The purpose of the present study was to evaluate the clinical outcome of CT-guided high-dose-rate brachytherapy (CT-HDRBT) in patients with unresectable... 相似文献
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David M Wagner Jennifer Klunk Michaela Harbeck Alison Devault Nicholas Waglechner Jason W Sahl Jacob Enk Dawn N Birdsell Melanie Kuch Candice Lumibao Debi Poinar Talima Pearson Mathieu Fourment Brian Golding Julia M Riehm David J D Earn Sharon DeWitte Jean-Marie Rouillard Hendrik Poinar 《The Lancet infectious diseases》2014,14(4):319-326
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AID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells 下载免费PDF全文
Michael Huemer Stefan Rebhandl Nadja Zaborsky Franz J. Gassner Stefan Hainzl Lukas Weiss Daniel Hebenstreit Richard Greil Roland Geisberger 《European journal of immunology》2014,44(12):3747-3757
The activation‐induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off‐target mutations, its activity has been associated with lymphomagenesis and clonal evolution of B‐cell malignancies. Although it has been shown that AID is expressed in B‐cell chronic lymphocytic leukemia (CLL), a clear analysis of in vivo AID activity in this B‐cell malignancy remained elusive. In this study performed on primary human CLL samples, we report that, despite the presence of a dominant VDJ heavy chain region, a substantial intraclonal diversity was observed at VDJ as well as at IgM switch regions (Sμ), showing ongoing AID activity in vivo during disease progression. This AID‐mediated heterogeneity was higher in CLL subclones expressing CD86, which we identified as the proliferative CLL fraction. Finally, CD86 expression correlated with shortened time to first treatment and increased γ‐H2AX focus formation. Our data demonstrate that AID is active in CLL in vivo and thus, AID likely contributes to clonal evolution of CLL. 相似文献
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Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia 下载免费PDF全文
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Schoenenberger AW Urbanek N Bergner M Toggweiler S Resink TJ Erne P 《The American journal of cardiology》2012,109(12):1711-1716
Although reactive hyperemia index (RHI) predicts future coronary events, associations with intravascular ultrasound (IVUS)-assessed coronary plaque structure have not been reported. This study therefore investigated associations between RHI and IVUS-assessed coronary plaques. In 362 patients RHI was measured by noninvasive peripheral arterial tonometry and coronary plaque components (fibrous, fibrofatty, necrotic core, and dense calcium) were identified by IVUS in 594 vessel segments of the left anterior descending, circumflex, and/or right coronary arteries. RHI values <1.67 were considered abnormal. Analysis of variance was used to detect independent associations between RHI and plaque composition. Patients with an abnormal RHI had greater plaque burden (41% vs 39% in patients with normal RHI, p = 0.047). Compared to patients with normal RHI, plaque of patients with abnormal RHI had more necrotic core (21% vs 17%, p <0.001) and dense calcium (19% vs 15%, p <0.001) and less fibrous (49% vs 54%, p <0.001) and fibrofatty (11% vs 14%, p = 0.002) tissue. After adjustment for age, gender, cardiovascular risk factors, and drug therapy, abnormal RHI remained significantly associated with fibrous (F ratio 14.79, p <0.001), fibrofatty (F ratio 5.66, p = 0.018), necrotic core (F ratio 14.47, p <0.001), and dense calcium (F ratio 10.80, p = 0.001) volumes. In conclusion, coronary artery plaques of patients with abnormal RHI had a larger proportion of necrotic core and dense calcium. The association of an abnormal RHI with a plaque structure that is more prone to rupture may explain why these patients exhibit a greater risk of coronary events. 相似文献
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