全文获取类型
收费全文 | 783篇 |
免费 | 128篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 33篇 |
妇产科学 | 10篇 |
基础医学 | 142篇 |
口腔科学 | 8篇 |
临床医学 | 76篇 |
内科学 | 107篇 |
皮肤病学 | 3篇 |
神经病学 | 36篇 |
特种医学 | 64篇 |
外科学 | 87篇 |
综合类 | 23篇 |
预防医学 | 115篇 |
眼科学 | 1篇 |
药学 | 194篇 |
肿瘤学 | 13篇 |
出版年
2021年 | 9篇 |
2019年 | 9篇 |
2018年 | 24篇 |
2017年 | 8篇 |
2016年 | 21篇 |
2015年 | 11篇 |
2014年 | 15篇 |
2013年 | 38篇 |
2012年 | 28篇 |
2011年 | 20篇 |
2010年 | 17篇 |
2009年 | 19篇 |
2008年 | 19篇 |
2007年 | 25篇 |
2006年 | 32篇 |
2005年 | 17篇 |
2004年 | 30篇 |
2003年 | 20篇 |
2002年 | 16篇 |
2001年 | 25篇 |
2000年 | 18篇 |
1999年 | 19篇 |
1998年 | 17篇 |
1997年 | 21篇 |
1996年 | 16篇 |
1995年 | 7篇 |
1994年 | 8篇 |
1993年 | 9篇 |
1992年 | 20篇 |
1991年 | 16篇 |
1990年 | 12篇 |
1989年 | 23篇 |
1988年 | 23篇 |
1987年 | 25篇 |
1986年 | 18篇 |
1985年 | 14篇 |
1984年 | 10篇 |
1983年 | 14篇 |
1982年 | 11篇 |
1981年 | 12篇 |
1980年 | 25篇 |
1979年 | 20篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1976年 | 23篇 |
1975年 | 13篇 |
1974年 | 9篇 |
1972年 | 12篇 |
1971年 | 10篇 |
1969年 | 8篇 |
排序方式: 共有912条查询结果,搜索用时 15 毫秒
21.
The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission 总被引:2,自引:5,他引:2
Murray A; Macpherson JN; Pound MC; Sharrock A; Youings SA; Dennis NR; McKechnie N; Linehan P; Morton NE; Jacobs PA 《Human molecular genetics》1997,6(2):173-184
Factors involved in the stability of trinucleotide repeats during
transmission were studied in 139 families in which a full mutation,
premutation or intermediate allele at either FRAXA or FRAXE was
segregating. The transmission of alleles at FRAXA, FRAXE and four
microsatellite loci were recorded for all individuals. Instability within
the minimal and common ranges (0-40 repeats for FRAXA, 0-30 repeats for
FRAXE) was extremely rare; only one example was observed, an increased in
size at FRAXA from 29 to 39 repeats. Four FRAXA and three FRAXE alleles in
the intermediate range (41-60) repeats for FRAXA, 31-60 for FRAXE) were
unstably transmitted. Instability was more frequent for FRAXA intermediate
alleles that had a tract of pure CGG greater than 37 although instability
only occurred in two of 13 such transmissions: the changes observed were
limited to only one or two repeats. Premutation FRAXA alleles over 100
repeats expanded to a full mutation during female transmission in 100% of
cases, in agreement with other published series. There was no clear
correlation between haplotype and probability of expansion of FRAXA
premutations. Instability at FRAXA or FRAXE was more often observed in
conjunction with a second instability at an independent locus suggesting
genomic instability as a possible mechanism by which at least some FRAXA
and FRAXE mutations arise.
相似文献
22.
Lee BJ Ryu SG Choi HG Kim CK Parrott KA Ayres JW Sack RL 《Archives of pharmacal research》1997,20(6):555-559
The three different batches of an oral sustained release melatonin (MT) delivery system were prepared by aqueous-based fluid-bed coating of the sugar spheres for the evaluation ofin vitro release characteristics and plasma concentration profiles in human subjects. The MT contents in 20% coated sugar spheres of three batches (B1, B2 and B3) were 3.3+/-0.08, 2.4+/-0.1 and 2.5+/-0.13 mg per gram of coated sugar spheres, respectively. The release profiles of three different batches had a very similar fashion. However, the release half-lives (T(50%)) of MT from B1, B2 and B3 was 3.70+/-0.2, 5.2+/-0.2 and 4.9+/-0.07h, respectively. Plasma concentration profiles of sustained release 0.2mg melatonin-loaded sugar spheres containing 10% immediate release melatonin in gelatin capsules (B1 and B2) were then evaluated in human subjects. Thein vivo plasma concentration profiles of the two batches (B1 and B2) were very similar each other and located between the physiological endogenous ranges. The time to reach the peak concentration (T(max)) was more advanced in case of B1 when compared to B2. However, there was no statistically significant difference in the maximum concentration (C(max)) and the area under the curve (AUC) between B1 and B2. The AUC of melatonin-loaded sugar spheres containing 10% and 20% immediate release MT in human subjects had a good linearity between dose and AUC, regardless of the fraction of immediate release MT, indicating the first order elimination process of MT within these doses. The current oral sustained release MT delivery system may be utilized to treat circadian rhythm disorders if it is proven to be more clinically useful when compared to immediate release MT. 相似文献
23.
Risky single-occasion drinking (RSOD) has dire consequences upon health and
well-being including unplanned pregnancies, sexually transmitted diseases
such as HIV/AIDS, crime, and car accidents. The prevalence of RSOD among
young people is alarming. Despite this, as yet, a review of existing
literature on RSOD amongst young people is lacking. This article will
provide an overview of this area of research focusing on the definition of
RSOD, its prevalence among young people, health and behavioural effects of
RSOD, the perceived risk of RSOD among young people, and interventions to
reduce RSOD in young people. In addition, recommendations are made for
health educators interested in reducing the incidence of RSOD in young
people.
相似文献
24.
The palpation and enucleation of occult insulinomas (less than 15 mm) can be a difficult surgical problem even with good arteriographic localization. In the authors' limited experience, confirmation of arteriographic findings by pancreatic venous sampling provided little additional localizing information. However, if arteriography is negative or equivocal, venous sampling can indicate the segment of pancreas to be "blindly" resected if the adenoma is not palpable. Venous sampling may be misleading in polyendocrine syndromes because of the frequency of multiple adenomas and variable hormone production. 相似文献
25.
Parrott A 《Journal of psychopharmacology (Oxford, England)》1992,6(4):541-542
This symposium of the British Psychological Society Annual Conference was convened by Dr Andy Parrott (Department of Psychology, University of East London) and Dr Ian Deary (Department of Psychology, University of Edinburgh). The conference was held in Scarborough at the International Spa Complex in April 1992. 相似文献
26.
S-A Ivarsson D Bergqvist NR Lundström E Maly KO Nilsson C Wattsgård 《Acta paediatrica (Oslo, Norway : 1992)》1992,81(12):1044-1048
We report a case of Takayasu's disease with severe renovascular hypertension in a girl from Eritrea. In the "burn-out" phase after the erythrocyte sedimentation rate had normalized, reconstructive vascular surgery was performed as further progression of the disease seemed unlikely. However, probably due to her growth, the graft rotated and a second operation was successfully performed. 相似文献
27.
JJ Rangasami DC Greenwood B McSporran PJ Smail CC Patterson NR Waugh 《Archives of disease in childhood》1997,77(3):210-213
OBJECTIVES: To calculate the incidence of type 1 diabetes in Scottish children aged less than 15 years between 1984 and 1993; to examine changes in incidence; and to calculate the prevalence of diabetes at the end of this period. DESIGN: Three data sources were used to construct the Scottish Study Group for the Care of Young Diabetics register: active reporting of all new cases; reports from the Scottish Morbidity Register 1; and local registers. SUBJECTS: All children resident in Scotland diagnosed with primary insulin dependent diabetes mellitus when less than 15 years of age between 1984 and 1993. MAIN OUTCOME MEASURES: Annual incidence and prevalence rate for Scotland; time trend in incidence over the 10 years; differences in incidence between the three different age groups; and completeness of the register. RESULTS: The average annual incidence for Scotland was 23.9/100,000 children. The prevalence rate was 1.5/1000 in 1993. A total of 2326 cases was identified from the three sources. Capture-recapture analysis suggests a case ascertainment of 98.6%. The annual incidence rates increased at a rate of 2% each year (rate ratio = 1.02, 95% confidence interval (CI) 1.01 to 1.03). The incidence was higher in boys than girls (rate ratio = 1.08, 95% CI 1.00 to 1.18), and the incidence rates increased with age: 15.3/100,000/year for age 0-4 years, 24.4/ 100,000/year for age 5-9 years, and 31.9/ 100,000/year for age 10-14 years. CONCLUSIONS: The incidence of type 1 diabetes in Scotland is increasing and the prevalence is relatively high. These findings have important implications for health service resource allocation. The Scottish Study Group for the Care of Young Diabetics' register provides a base for monitoring and research. 相似文献
28.
Inpatient dependency in activities of daily living predicts informal caregiver strain: A cross‐sectional study
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
29.