全文获取类型
收费全文 | 156篇 |
免费 | 2篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 18篇 |
基础医学 | 7篇 |
临床医学 | 17篇 |
内科学 | 41篇 |
神经病学 | 20篇 |
外科学 | 38篇 |
综合类 | 1篇 |
药学 | 13篇 |
中国医学 | 2篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2017年 | 1篇 |
2016年 | 2篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 2篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 5篇 |
2009年 | 3篇 |
2008年 | 3篇 |
2007年 | 1篇 |
2006年 | 18篇 |
2005年 | 5篇 |
2004年 | 7篇 |
2003年 | 10篇 |
2002年 | 6篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 7篇 |
1998年 | 13篇 |
1997年 | 11篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1994年 | 8篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1979年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有160条查询结果,搜索用时 15 毫秒
111.
SHUJI TERAO YUJI YAMADA TOSHIRO SHIRAKAWA ISAO HARA NAOKI KANOMATA SADAO KAMIDONO 《International journal of urology》2005,12(5):500-502
We report a case of granulocyte-colony stimulating factor (G-CSF) producing urothelial carcinoma of the renal pelvis in a 39-year old man. The patient was admitted to Kobe University Hospital, Kobe, Japan, complaining of macrohematuria and a 6-month history of left abdominal swelling. Abdominal computed tomography showed a large mass in the left kidney and para-aortic lymph node enlargement. A remarkable degree of leukocytosis was detected without any acute infectious disease. Enzyme immunoassay of the serum demonstrated a remarkable high concentration of G-CSF. The patient underwent left nephroureterectomy and para-aortic lymphadenectomy. Histochemical examination revealed urothelial carcinoma. Immunohistochemical staining with an anti-G-CSF antibody demonstrated G-CSF secreting cells. The patient died 8 weeks after the surgical operation. To our knowledge, this is the second case of G-CSF producing urothelial carcinoma of renal pelvis reported in the English literature. 相似文献
112.
KOJI YOSHIMURA YOICHI ARAI KENTARO ICHIOKA NAOKI TERADA YOSUKE MATSUTA KAZUTOSHI OKUBO 《International journal of urology》2002,9(9):485-490
BACKGROUND: We investigated which factors are most bothersome to preoperative patients with benign prostatic hyperplasia (BPH). METHODS: A total of 423 newly diagnosed patients and 388 preoperative patients with symptomatic BPH were evaluated. International prostate symptom score (IPSS) and IPSS quality-of-life (QOL) assessment score were used for assessment of symptoms and symptom-specific QOL of the patients with BPH. Uroflow variables were measured in all patients. Other objective variables such as prostate volume, transition zone volume, Schaefer's obstruction grade, and detrusor pressure at maximal urinary flow were evaluated in 209 preoperative patients. We analyzed the relationships between symptom-specific QOL and other variables. Statistical analyses were performed using Spearman's correlation coefficient and a stepwise linear regression model. RESULTS: Symptom-specific QOL scores had moderate to good correlation with IPSS (P < 0.0001; r = 0.525-0.560). Filling symptom subscore had a slightly greater impact on symptom-specific QOL than voiding subscore in both groups of patients. Weak stream, feeling of incomplete emptying, and nocturia significantly decreased symptom-specific QOL in both groups of patients. While newly diagnosed patients suffered from frequency as well, urgency had the strongest impact on symptom-specific QOL of preoperative patients. Objectively measurable variables had no association with symptom-specific QOL. CONCLUSION: Japanese patients with BPH generally suffer from weak stream, feeling of incomplete emptying, and nocturia in all disease phases. Frequency is problematic for newly diagnosed patients and urgency is problematic for preoperative patients as well. Symptom-specific QOL of BPH patients cannot be estimated by physically measurable variables. 相似文献
113.
NAOKI AIHARA SUSUMU TAZUMA GORO KAJIYAMA 《Journal of gastroenterology and hepatology》1995,10(1):42-46
Abstract Bile salts can be cytotoxic to mucosal surfaces, because of their detergent properties. This is not normally seen under physiological circumstances in the gall-bladder. To further study normal mucosal defence mechanisms, the present study was performed to examine the effects of liposomes and hydrophilic bile salts on hydrophobic bile salt-induced release of radiolabelled glycoproteins from explants of guinea-pig gall-bladder. Glycoprotein release was correlated with the degree of hydrophobicity of bile salts, as determined by the retention factor in reversed-phase high-performance liquid chromatography. Hydrophobic bile salt-induced release of glycoproteins was reduced by liposomes and hydrophilic bile salts. The inhibitory effect of liposomes was directly related to the degree of saturation of their fatty acyl chains, and that of hydrophilic bile salts was related to the degree of hydrophilicity. These findings suggest that vesicles and hydrophilic bile salts may play a cytoprotective role against membrane damage passively caused by hydrophobic bile salts in the biliary system, and that such damage may occur according to the quantitative and qualitative imbalance among these factors. 相似文献
114.
NAOKI SAKANE MD TOSHIHIDE YOSHIDA MD TUNEKAZU UMEKAWA MD MOTOHARU KONDO MD YASUHIDE NAGOSHI MD 《Psychiatry and clinical neurosciences》1995,49(2):147-149
Abstract A 66 year old man who had been treated under a diagnosis of depression for 10 years was referred to the Kyoto Prefectural University of Medicine, Kyoto because of general fatigue and appetite loss. The patient was diagnosed as having primary hyperparathyroidism (PHPT) based on the increased parathyroid hormone (PTH) and serum calcium levels. Computed tomography revealed solitary adenoma of parathyroid gland. The resection of this solitary adenoma improved the PTH and serum calcium concentrations to normal ranges, which resulted in an improvement in his depressive state. This case suggests that ionic calcium levels contribute to the mental symptoms associated with PHPT. As PHPT is curable, the possibility of PHPT should be taken into account when patients have depressive symptoms. 相似文献
115.
MAKOTO HIGURASHI MASAYA SEGAWA ICHIRO MATSUI KAZUZO IHNUMA YASUO NAKAGOME 《Acta paediatrica (Oslo, Norway : 1992)》1977,66(4):501-504
Abstract. A method of screening for autosomal aberrations is important as an indication for chromosome analysis such as that used in sex-chromatin examination for sex chromosome aberrations. In our clinic, malformed patients with mental retardation and abnormal dermatoglyphic patterns are strong suspects for autosomal aberrations. Abnormal dermatoglyphic patterns are separated into two categories: (1) Absolutely abnormal—radial loop of 1st finger, radial loop of 4th finger, radial loop of 5th finger, arch over 6 fingers, arch tibial, loop tibial, and arch fibular; (2) Borderline abnormalities—high axial triradius (t' and t"), simian crease, interdigital loop, and single crease of 5th finger. Of 416 cases showing malformation, retardation, and abnormal dermatoglyphics, 308 had autosomal aberrations, while 108 had normal karyotypes. In the group with autosomal aberrations, 279 patients (90.6%) had absolutely abnormal dermatoglyphics. In the group with normal karyotypes only 8 patients (7.4%) had absolutely normal dermatoglyphics, while most had abnormal dermatoglyphics in the borderline category. These clinical manifestations: absolutely abnormal dermatoglyphics, mental retardation, and malformations are therefore very useful in screening for autosomal aberrations. 相似文献
116.
该文研究土壤消毒、绿肥回田、施肥过程中土壤微生态环境的变化,初步建立农田土壤改良方法,保证农田栽参的顺利进行。研究分析了土壤消毒、消毒+绿肥回田及消毒+绿肥回田+施肥处理后农田土壤理化性状、细菌群落多样性及组成,结果表明改良措施降低土壤p H,增加土壤肥力,降低土壤细菌多样性,改变细菌群落的组成。消毒+绿肥回田+施肥的综合措施降低移栽参苗死亡率。该研究表明土壤消毒、消毒+绿肥回田、消毒+绿肥回田+施肥的措施改变农田土壤微生态环境,综合改良措施提高参苗存苗率,保障农田栽参的开展。 相似文献
117.
118.
Experimental His-Bundle Pacing: Histopathological and Electrophysiological Examination 总被引:4,自引:0,他引:4
SHIGERU AMITANI KENKICHI MIYAHARA HIROSHI SOHARA HIDEAKI KAKURA MASAAKI KOGA YUKINORI MORIYAMA AKIRA TAIRA SHIN-ICHI NAGANO † NAOKI MIURA † KAZUHIRO MISUMI † HIROSHI SAKAMOTO† 《Pacing and clinical electrophysiology : PACE》1999,22(4):562-566
His-bundle pacing gives a more physiological ventricular contraction in comparison to right ventricular apical pacing. However the problems of lead fixation and stability of long-term His-bundle pacing are yet unsolved. We used six adult beagles, in which a screw-in lead was anchored in the His-bundle region for observation of the pacing conditions and histopathologic changes of the conduction system over the course of 2 months. In the results, a satisfactory fixation was obtained using a conventional screw-in lead and no histological influence on the conduction system was observed. The pacing threshold at the time of implantation was 1.15 ± 0.69V (3.23 ± 3.08 mA) in the pulse width of 0.5 ms. R wave amplitude, the impedance and slew rate were 7.28 ± 2.04 mV, 409 ± 102 Ohm, and 0.65 ± 0.41 V/s, respectively. Two months later, these parameters changed to 2.83 ± 1.06 V (10.4 ± 5.71 mA), 5.63 ± 1.62 mV, 310 ± 71.3 Ohm, and 0.49 ± 0.22 V/s, respectively. These results suggest the feasibility of clinical application of permanent His-bundle pacing. 相似文献
119.
TAKUMI YAMADA M.D. Ph. D. HARISH DOPPALAPUDI M.D. HUGH T. McELDERRY M.D. TARO OKADA M.D. † YOSHIMASA MURAKAMI M.D. † YASUYA INDEN Ph. D.‡ YUKIHIKO YOSHIDA M.D. ¶ SHINJI KANEKO Ph. D.‡ NAOKI YOSHIDA M.D. ‡ TOYOAKI MUROHARA Ph. D.‡ REW E. EPSTEIN M.D. VANCE J. PLUMB M.D. G. NEAL KAY M.D. 《Journal of cardiovascular electrophysiology》2010,21(1):62-69
Idiopathic VAs Originating from the LV Papillary Muscles. Introduction: Idiopathic ventricular arrhythmias (VAs) can originate from the left ventricular (LV) papillary muscles (PAMs). This study investigated the prevalence, electrocardiographic and electrophysiological characteristics, and results of catheter ablation of these VAs, and compared them with other LV VAs.
Methods and Results: We studied 71 patients with VAs originating from the LV anterolateral and posteroseptal regions among 159 patients undergoing successful catheter ablation of idiopathic LV VAs. PAM VAs were uncommon, rare in a sustained form, and more common from the posterior papillary muscle (PPM) than anterior papillary muscle (APM). A younger age was a good predictor for differentiating left posterior fascicular VAs from PPM VAs. There were several electrocardiographic features that accurately differentiated PAM and LV fascicular VAs from mitral annular VAs. However, an R/S ratio ≤1 in lead V6 in the LV anterolateral region and a QRS duration >160 ms in the LV posteroseptal region were the only reliable predictors for differentiating PAM VAs from LV fascicular VAs. A sharp ventricular prepotential was recorded at the successful ablation site during 42% of the PAM VAs. Radiofrequency current with an irrigated or conventional 8-mm tip ablation catheter was required to achieve a lasting ablation of the PAM VA origins whereas that with a nonirrigated 4-mm tip ablation catheter produced excellent results in LV fascicular and mitral annular VAs.
Conclusions: There are differences in the electrocardiographic and electrophysiological features among VAs originating from these regions that are helpful for their diagnosis and effective catheter ablation. (J Cardiovasc Electrophysiol, Vol. 21, pp. 62–69, January 2010) 相似文献
Methods and Results: We studied 71 patients with VAs originating from the LV anterolateral and posteroseptal regions among 159 patients undergoing successful catheter ablation of idiopathic LV VAs. PAM VAs were uncommon, rare in a sustained form, and more common from the posterior papillary muscle (PPM) than anterior papillary muscle (APM). A younger age was a good predictor for differentiating left posterior fascicular VAs from PPM VAs. There were several electrocardiographic features that accurately differentiated PAM and LV fascicular VAs from mitral annular VAs. However, an R/S ratio ≤1 in lead V6 in the LV anterolateral region and a QRS duration >160 ms in the LV posteroseptal region were the only reliable predictors for differentiating PAM VAs from LV fascicular VAs. A sharp ventricular prepotential was recorded at the successful ablation site during 42% of the PAM VAs. Radiofrequency current with an irrigated or conventional 8-mm tip ablation catheter was required to achieve a lasting ablation of the PAM VA origins whereas that with a nonirrigated 4-mm tip ablation catheter produced excellent results in LV fascicular and mitral annular VAs.
Conclusions: There are differences in the electrocardiographic and electrophysiological features among VAs originating from these regions that are helpful for their diagnosis and effective catheter ablation. (J Cardiovasc Electrophysiol, Vol. 21, pp. 62–69, January 2010) 相似文献
120.
KATSUMI Torigoe OSAMU Numata TAKASHI Sato CHIHAYA Imai KAZUO Takeuchi HAJIME Yamazaki HIROMITSU Hotta NAOKI Boku SATOSHI Yazaki SHYOJI Sudo ATSUSHI Kuwabara SATOSHI Hasegawa & MAKOTO HIURA HARUYOSHI Ino 《Pediatrics international》1999,41(3):285-291
BACKGROUND: Central catecholamines, particularly dopaminergic and noradrenergic systems, have affected the appetitive behavior in patients with anorexia nervosa (AN). The purpose of this study is to distinguish the characteristics of contingent negative variation (CNV) and postimperative negative variation (PINV), which may reflect the level of catecholamine in children with AN. METHODS: Eight children with AN aged 10 to 15 years and 23 age-matched healthy children were recruited. Contingent negative variation was recorded from the frontal midline (Fz), central midline (Cz) and parietal midline (Pz) referenced to linked earlobes during 30 trials consisting of a warning stimulus and an imperative stimulus with an interstimulus interval of 2 s and an intertrial interval of 10 s. The imperative stimulus of each trial required a button press. RESULTS: Children with AN had a diminished amplitude of the CNV. They had a significantly more attenuated early CNV and late CNV amplitude at Cz than normal children. No significant differences were observed between AN children and normal children in the amplitude of PINV at all three electrode sites. No difference could be found between the two groups in the frequencies of normal and abnormal duration of PINV. CONCLUSION: These findings suggest that early CNV may be diminished by norepinephrine deficiency and late CNV may be attenuated by dopaminergic deficiency in children with AN. Reduced CNV may represent impaired cognitive processes which reflect impaired appetitive behavior in AN children. 相似文献