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排序方式: 共有433条查询结果,搜索用时 15 毫秒
31.
Purpose
We measured health utility scores of colorectal cancer (CRC) patients from a societal perspective in Japan. 相似文献32.
Masutani K Fujisaki K Maeda H Toyonaga J Inoshima I Takayama K Katafuchi R Hirakata H Tsuruya K Iida M 《Clinical and experimental nephrology》2008,12(5):398-402
A 52-year-old Japanese female was admitted to our hospital for microhematuria, proteinuria and progressive renal dysfunction.
Two years prior to admission, she was diagnosed with lung adenocarcinoma and multiple bone and brain metastases, and was treated
with gefitinib (250 mg/day). Treatment for 6 months induced partial response with 30% regression of the primary lung tumor,
and resolution of metastatic tumors. After confirmation of the partial remission state, we performed percutaneous renal biopsy.
Glomeruli showed mild to moderate mesangial proliferation, segmental endocapillary proliferation and occasional fibrocellular
crescent formation. In addition, severe interstitial fibrosis and tubular atrophy relative to the degree of glomerular sclerosis
were noted. Immunofluorescence microscopy showed predominant IgA deposition in the mesangial area. Electron microscopy revealed
subepithelial and paramesangial electron-dense deposits. In consideration of the prognosis of lung cancer and complication
of immunosuppressive treatment, we continued gefitinib only and closely followed-up the clinical course in the outpatient
clinic. Sixteen months later, she continued to have proteinuria and microhematuria, and the severity of renal dysfunction
was still the same. However, the lung cancer started to increase in size. This is quite an unusual case presenting histologically
with tubulointerstitial nephritis and IgA nephropathy in a patient on long-term treatment with gefitinib. 相似文献
33.
W. NAKA S. MIYAKAWA H. NIIZEKI T. FUKUDA Y. MIKAMI† T. NISHIKAWA 《The British journal of dermatology》1995,132(4):609-613
Summary We report a patient with primary lymphocutaneous Nocardia brasiliensis infection affecting the face and left arm. The mode of infection was via skin abrasions which occurred 2 weeks prior to the development of the skin lesions. Treatment with intravenous minocycline for 4 weeks resulted in a cure. We also review 12 previously reported Japanese cases of lymphocutaneous nocardiosis. 相似文献
34.
Atsushi Iguchi Goro Takahashi Kiichiro Kumagai Kaoru Iwabuchi Yuji Wakayama Koichi Tabayashi 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):390-394
A 35-year-old man presented to our institution one day after the onset of dyspnea. Coronary angiography revealed the occlusion
of the left main trunk. The left main coronary artery and the left circumflex artery were recanalized, but he was hypotensive
with low cardiac output. Even after he was placed on circulatory support with veno-arterial extracorporeal membrane oxygenation
(ECMO), hemodynamic deterioration could not be reversed, and lung edema developed. The decision was made to use Toyobo LVAS?.
With institution of left ventricular assist system (LVAS), however, the patient’s arterial saturation decreased. Peripheral
veno-venous (V-V) ECMO was promptly established, and the patient’s arterial saturation improved. On postoperative day 3, the
patient was successfully weaned from V-V ECMO. He was extubated on postoperative day 28. The patient was recovered without
any serious complications. Although echocardiography showed no substantial improvement in left ventricular function, his general
condition is doing quite well with the assist of Toyobo LVAS?. He is on rehabilitation program and awaiting heart transplantation. 相似文献
35.
Nishiura S Nakashima Y Mori K Kodama T Hirai S Kurakake T Egami C Morita K 《The Kurume medical journal》2007,54(3-4):65-72
To evaluate age and gender differences as well as effects of affection, we examined exploratory eye movements. Exploratory eye movements were recorded in healthy subjects (57 women and 57 men) ranging from 9 to 74 years. All subjects were divided into three groups as pre puberty, young, and older adults to study the influences of age and gonadal hormones. Exploratory eye movements were analyzed for total eye scanning length (TESL), and total numbers of gaze points (TNGP) as subjects viewed neutral or affectively charged pictures. TESL and TNGP in older adults were significantly larger than that in both pre puberty and young adults for crying babies. TESL and TNGP in pre puberty were significantly smaller than that in both young and older adults for circles. TESL and TNGP in pre puberty were significantly smaller than that in older adults for smiling babies. Pre puberty and young adult of both genders for crying babies showed significantly shorter TESL than for when smiling babies. When viewing circles, young adult women had shorter TESL than men. TNGP in young adult women was smaller than in men for circles or crying babies. TNGP of young adult women in the visual right field was significantly smaller than in men. TNGP for crying babies was significantly smaller than that for smiling babies in young adults of both genders for the left field. Exploratory eye movements thus are a useful marker of visual cognitive function. Gender differences were limited to younger adults, suggesting influences of gonadal hormones. 相似文献
36.
Naoki Masaki Kiichiro Kumagai Konosuke Sasaki Satoshi Matsuo Naotaka Motoyoshi Osamu Adachi Masatoshi Akiyama Shunsuke Kawamoto Koichi Tabayashi Yoshikatsu Saiki For the STANP trial investigators 《General thoracic and cardiovascular surgery》2018,66(6):334-343
Objectives
Medical therapy for patients with uncomplicated acute type B aortic dissection (ABAD) is essentially accepted for its excellent early outcome; however, long-term outcomes have not been satisfactory due to aorta-related complications. This trial was performed to investigate the efficacy of a statin as an additive that may enhance the effectiveness of conventional medical treatment in patients with ABAD.Methods
This was a multi-center, prospective, and randomized comparative investigation of patients with uncomplicated ABAD. Fifty patients with ABAD compatible with inclusion criteria were randomly assigned to two groups and then received administration of pitavastatin (group P) or not (group C). We followed up the patients for 1 year from study onset.Results
Two patients demised during the follow-up period (both were in group C). In addition, aorta-related interventions were performed in two patients (entry closure for aortic dissection by endovascular repair in one patient in each group). Aortic arch diameters at 1 year in group P tended to be smaller than in group C (P?=?0.17), and the rate of change of the aortic arch diameters from onset to 1 year was significantly lower in group P (P?=?0.046). Multivariate analysis identified patency of the false lumen was detected as a risk factor for aortic arch dilatation (P?=?0.02), and pitavastatin intake was a negative risk factor (P?=?0.03).Conclusions
Pitavastatin treatment, in addition to the standard antihypertensive therapy, may have a suppressive effect on aortic arch dilatation in patients with ABAD.37.
Shibuya T Uchiyama K Kokuma M Shioya T Watanabe Y Moriyama Y Matsumoto K Yokosuka I 《Journal of gastroenterology》2002,37(5):387-390
Received: October 31, 2000 / Accepted: March 30, 2001 相似文献
38.
Role of Duodenum on Sphincter of Oddi Motility in Conscious Dogs 总被引:2,自引:0,他引:2
Sonoda Y Dong M Konomi H Kawamoto M Kobayashi K Yamaguchi K Tanaka M 《Digestive diseases and sciences》2003,48(9):1693-1700
Our aim was to determine the role of the duodenum in controlling sphincter of Oddi motility using conscious dogs after total duodenectomy. In a control group (N = 6), a cannula was implanted into the duodenum opposite to the papilla to allow retrograde sphincter manometry. In a duodenectomy group (N = 6), the papillae were preserved at total duodenectomy and sutured to the jejunum anastomosed to the stomach (neoduodenum). The cannula was implanted opposite to the implanted papillae. Interdigestive and postprandial sphincter and duodental or neoduodenal motility were recorded by manometric and myoelectric methods. Duodenectomy disrupted sphincter cyclic motility associated with the intestinal migrating motor complex and increased sphincter activity throughout the cycle. Sphincter activity increased immediately after feeding and did not differ between the two groups. In conclusion, during the interdigestive period, the duodenum has a distinct role in regulating sphincter cyclic motility. The initiation of the fed pattern of sphincter motility does not need the duodenum. 相似文献
39.
Daisuke Suzuki Mitsunori Yagame Kiichiro Jinde Raita Naka Naohiro Yano Masayuki Endoh Hideaki Kaneshige Yasuo Nomoto Hideto Sakai 《Journal of diabetes and its complications》1996,10(6):314-319
This is the first report on immunofluorescence staining of renal biopsy samples in human diabetic nephropathy (DN) using monoclonal antibodies to reduced glycated lysine. In order to detect the localization of glycated lysine in the mesangial matrix and/or the glomerular basement membrane (GBM), we examined immunofluorescence staining using antibodies against reduced glycated lysine in the glomeruli of 16 patients with DN and ten age-matched patients with diffuse mesangial proliferative glomerulonephritis without IgA deposition (DPGN) as controls. In the early stage of DN, immunofluorescence microscopy revealed the presence of intense staining for reduced glycated lysine in the GBM as well as in part of the tubular basement membrane, but not in the mesangial area. In contrast, immunofluorescence microscopy revealed less staining for glycated lysine in the GBM in the advanced stage of DN, and no reaction with any part of the renal tissue in patients with DPGN. It was concluded that detection of reduced glycated lysine in GBM in the early stage of DN might be associated with the initial pathogenesis of this disease. 相似文献
40.
Duodenum is important for the sphincter of Oddi motor response to cholecystokinin octapeptide in conscious dogs 总被引:4,自引:0,他引:4
Dong M Sonoda Y Kawamoto M Konomi H Kobayashi K Yamaguchi K Tanaka M 《Journal of gastroenterology》2005,40(4):389-395
Background We investigated the role of the duodenum in the sphincter of Oddi response to cholecystokinin-octapeptide (CCK-OP), using conscious dogs.Methods In controls, a cannula was inserted into the duodenum opposite the papilla for retrograde manometry. In the duodenectomy group, the entire duodenum was resected, while preserving the papilla, which was implanted into the jejunum, and the cannula was placed. Sphincter motility was recorded after bolus injections of 20 and 100ng/kg of CCK-OP.Results CCK-OP at 20ng/kg produced sphincter relaxation followed by contraction in the controls, but produced no changes after duodenectomy. CCK-OP at 100ng/kg caused strong contractions followed by relaxation in the controls, but caused only contractions after duodenectomy.Conclusions (1) Relaxation and delayed contraction of the sphincter induced by 20ng/kg of CCK-OP require the presence of the duodenum; (2) early contractions of the sphincter induced by 100ng/kg of CCK-OP do not require the duodenum; (3) the duodenum plays an important role in the actions of CCK-OP on sphincter motility. 相似文献