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排序方式: 共有2421条查询结果,搜索用时 15 毫秒
91.
Joachim Schofer Antonio Colombo Silvio Klugmann Jean Fajadet Federico DeMarco Didier Tchétché Francesco Maisano Giuseppe Bruschi Azeem Latib Klaudija Bijuklic Neil Weissman Reginald Low Martyn Thomas Christopher Young Simon Redwood Michael Mullen John Yap Eberhard Grube Georg Nickenig Jan-Malte Sinning Karl Eugen Hauptmann Ivar Friedrich Michael Lauterbach Michael Schmoeckel Charles Davidson Thierry Lefevre 《Journal of the American College of Cardiology》2014
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94.
Jackson Y. Wong Paul Kuzel John Mullen Dale Lien Muhammad Mahmood Carol Conrad Loretta Fiorillo 《Pediatric transplantation》2014,18(6):E200-E207
Oral voriconazole is commonly used for treatment and prophylaxis of invasive fungal disease post‐LTx. Development of cutaneous SCC has been described in adult LTx recipients, although it is extremely rare in children. We describe two Caucasian children who developed cutaneous SCC beyond three yr post‐LTx. Both developed severe photosensitivity, actinic keratosis and required curative surgical excision of the cutaneous SCC lesions. Neither patient developed metastatic lesions nor had allograft dysfunction as a result of the SCC or the change in medical treatments. The effect of voriconazole on the development of malignant skin lesions is discussed and a recommendation on dermatologic surveillance, preventive measures against phototoxicity and early treatment of SCC are provided. 相似文献
95.
J. Y. Wong A. L. Chambers J. Fuller A. Lacson J. Mullen D. Lien A. Humar 《Pediatric transplantation》2014,18(5):E169-E173
Fungal respiratory infections in patients with CF are a significant concern both pre‐ and post‐lung transplantation (LTx). Fungal infection is associated with increased mortality post‐LTx, and in the past decade, the prevalence of fungal colonization in Canadian pediatric patients with CF has increased. The emergence of novel fungal pathogens is particularly challenging to the transplant community, as little is known regarding their virulence and optimal management. We present a case of a successful double‐lung transplant in a pediatric patient with CF who was infected pretransplantation with a novel yeast, Blastobotrys rhaffinosifermentans. This patient was treated successfully with aggressive antifungal therapy post‐transplantation, followed by extended fungal prophylaxis. The significance of fungal colonization and infection in children with CF pre‐ and post‐LTx is reviewed. 相似文献
96.
Systemic non‐biologic agents have long been in clinical use in medicine – often with considerable efficacy, albeit with some adverse effects – as with all medications. With the advent of biologic agents, all of which currently are restricted to systemic use, there is a growing need to ensure which agents have the better therapeutic ratio. The non‐biologic agents (NBAs) include a range of agents, most especially the corticosteroids (corticosteroids). This study reviews the corticosteroids in systemic use in management of orofacial mucocutaneous diseases; subsequent studies discuss corticosteroid‐sparing agents used in the management of orofacial diseases, such as calcineurin inhibitors used to produce immunosuppression; purine synthetase inhibitors; and cytotoxic and other immunomodulatory agents. 相似文献
97.
98.
Peter Mullen Alison Ritchie Simon P. Langdon William R. Miller 《International journal of cancer. Journal international du cancer》1996,67(6):816-820
The effect of Matrigel, a solubilised tissue basement membrane extract, has been investigated on the tumorigenicity of 3 breast (MCF-7, T47D and MDA.MB.231) and 5 ovarian [PEO1, PEO1 cDDPr, PEO4, PEO14 and OV(hyg)CAR3] carcinoma cell lines. In the absence of Matrigel, the PEO14 and MDA.MB.231 cell lines produced take rates of 30% and 50%, respectively, while the other cell lines either did not develop or only occasionally developed as tumours. With Matrigel, 100% take rates were achieved for 7 of the 8 cell lines (MCF-7, T47D, MDA.MB.231, PEO1, PEO1 cDDPr, PEO4 and PEO14); in the remaining cell line [OV(hyg)CAR3] 2/6 (33%) tumours grew. Xenografts established with Matrigel could be transferred into recipient animals and grown in the absence of Matrigel, suggesting that Matrigel is necessary only for initial establishment of tumours. Furthermore, cells which had been re-established from a T47D xenograft and then inoculated into mice without Matrigel showed a take rate greater than that of the original cell line but less than that of the xenograft. In conclusion, Matrigel has proven to be extremely useful in establishing a variety of cell lines as xenografts. © 1996 Wiley-Liss, Inc. 相似文献
99.
Richard Mullen Robert Howard Anthony David Raymond Levy 《International journal of geriatric psychiatry》1996,11(7):645-651
Increasing interest in insight and anosognosia in neuropsychiatric illness has been accompanied by growing academic study of such awareness phenomena in Alzheimer's disease. This article reviews the current status of knowledge of this topic and makes the case that insight and anosognosia are concepts with direct clinical relevance to Alzheimer's disease. The associated symptomatology, and implications for patient management, are emphasized. Such relevance should form the basis for future research. 相似文献
100.
Logan Wright Traci Mullen Kerry West Phillip Wyatt 《Journal of clinical psychology》1993,49(6):790-798
A scale is developed for measuring the overprotecting vs. optimal developmental stimulation tendencies for parents of physically “vulnerable” children. A series of items were administered to parents whose parenting techniques had been rated as either highly overprotective or as optimal by a group of MDs and other professionals. Correlations were estimated between each of the items and parental tendencies as rated by professionals. Twenty-eight items were selected that provided maximum prediction of overprotection. The resulting R2 was extraordinarily high (.94). Coefficient alpha and test-retest coefficients were acceptable. It is hoped that release of the new instrument (VCOPS) at this time will allow others to join in determining the clinical and experimental validity of this scale. 相似文献