全文获取类型
收费全文 | 1314篇 |
免费 | 48篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 45篇 |
妇产科学 | 16篇 |
基础医学 | 133篇 |
口腔科学 | 38篇 |
临床医学 | 95篇 |
内科学 | 243篇 |
皮肤病学 | 17篇 |
神经病学 | 67篇 |
特种医学 | 23篇 |
外科学 | 319篇 |
综合类 | 45篇 |
一般理论 | 1篇 |
预防医学 | 85篇 |
眼科学 | 57篇 |
药学 | 70篇 |
中国医学 | 5篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 9篇 |
2022年 | 41篇 |
2021年 | 38篇 |
2020年 | 24篇 |
2019年 | 35篇 |
2018年 | 46篇 |
2017年 | 32篇 |
2016年 | 20篇 |
2015年 | 39篇 |
2014年 | 60篇 |
2013年 | 69篇 |
2012年 | 90篇 |
2011年 | 101篇 |
2010年 | 47篇 |
2009年 | 59篇 |
2008年 | 78篇 |
2007年 | 78篇 |
2006年 | 82篇 |
2005年 | 92篇 |
2004年 | 66篇 |
2003年 | 62篇 |
2002年 | 45篇 |
2001年 | 16篇 |
2000年 | 11篇 |
1999年 | 16篇 |
1998年 | 11篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1993年 | 6篇 |
1992年 | 11篇 |
1991年 | 14篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1982年 | 4篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1973年 | 2篇 |
1970年 | 4篇 |
1969年 | 5篇 |
1935年 | 2篇 |
1933年 | 2篇 |
1932年 | 3篇 |
1930年 | 4篇 |
1927年 | 2篇 |
1904年 | 1篇 |
排序方式: 共有1373条查询结果,搜索用时 15 毫秒
41.
Nusret Soylu Ahmet Hamdi Alpaslan Muhammed Ayaz Selcen Esenyel Mücahit Oruç 《Research in developmental disabilities》2013,34(12):4334-4342
The purpose of this study was to compare sexually abused children and adolescents, with and without intellectual disabilities (ID), in terms of post-abuse psychiatric disorders, features of the sexual abuse, and sociodemographic characteristics. The study included sexually abused children aged 6–16 years, who were sent to three different child mental health units for forensic evaluation; there were 102 cases (69 girls and 33 boys) with ID and 154 cases (126 girls and 28 boys) without ID. Researchers retrospectively examined the files, social examination reports, and the judicial reports of the cases. It was determined that in the group with ID, sexual abuse types including penetration and contact had higher rates, they were exposed to more frequent repeated abuses, the abuses were revealed with their own reports at a later period and lower rates, and post-abuse pregnancies were more frequent. It was also determined that the abuser was a familiar person and a family member at lower rates and more than one abuser was encountered more frequently, compared to the group without ID. While no difference was determined between the two groups in terms of the frequency of post-abuse post-traumatic stress disorder (PTSD) and major depressive disorder (MDD), conduct disorder (CD) was observed more frequently in the group with ID. This study emphasizes that sexual abuse, which is an important problem in individuals with ID, has different features and effects. 相似文献
42.
43.
44.
Rashad Al-Salahi Moustapha E. Moustapha Hatem A. Abuelizz Abdulrahman I. Alharthi Khalid A. Alburikan Ismail T. Ibrahim Mohamed Marzouk Mohamed A. Motaleb 《Saudi Pharmaceutical Journal》2018,26(8):1120-1126
3-Benzyl-2-((3-methoxybenzyl)thio)benzo[g]quinazolin-4(3H)-one was previously synthesized and proved by physicochemical analyses (HRMS, 1H and 13C NMR). The target compound was examined for its radioactivity and the results showed that benzo[g]quinazoline was successfully labeled with radioactive iodine using NBS via an electrophilic substitution reaction. The reaction parameters that affected the labeling yield such as concentration, pH and time were studied to optimize the labeling conditions. The radiochemical yield was 91.2?±?1.22% and the in vitro studies showed that the target compound was stable for up to 24?h. The thyroid was among the other organs in which the uptake of 125I-benzoquinazoline has increased significantly over the time up to 4.1%. The tumor uptake was 6.95%. Radiochemical and metabolic stability of the benzoquinazoline in vivo/in vitro and biodistribution studies provide some insights about the requirements for developing more potent radiopharmaceutical for targeting the tumor cells. 相似文献
45.
Murat Guney Abdullah Ozkok Yasar Caliskan Hamdi Pusuroglu Halil Yazici Savas Tepe Huseyin Oflaz Alaattin Yildiz 《International urology and nephrology》2014,46(3):599-605
Purpose
QT dispersion (QTd) was shown to be an independent predictor of mortality in hemodialysis (HD) patients. It may be hypothesized that coronary artery calcification is related to QTd in HD patients because widespread calcification may also involve the cardiac conducting system in these patients. In this study, we aimed to investigate the relationships of corrected QTd (QTcd) with coronary artery calcification score (CACS), carotid plaque score (CPS) and possible influence of these parameters on survival of HD patients.Methods
Seventy-two HD patients (33 male, 39 female) were enrolled into the study. Mean age of the patients was 44 ± 12 years. Mean follow-up duration was 77 ± 24 months. CACS was determined by computed tomography. QTcd values were calculated as the difference of maximum and minimum QT intervals. Left ventricular mass index (LVMI) and CPS were measured by echocardiography.Results
QTcd was significantly correlated with CACS (r = 0.233, p = 0.049), CPS (r = 0.354, p = 0.003) and LVMI (p = 0.011, r = 0.299). CPS was found to be significantly higher in the group with high QTcd (>60 ms) [2 (1–4) versus 0 (0–1), p = 0.02]. CACS was significantly correlated with age (r = 0.44, p < 0.001), LVMI (r = 0.52, p < 0.001) and CPS (r = 0.32, p = 0.003). In Kaplan–Meier analysis, survival of patients with high QTcd was significantly lower than the patients with low QTcd. In Cox regression analysis for predicting mortality, age, serum albumin and QTcd were found to be the independent predictors of mortality.Conclusions
QTcd independently predicted mortality, and it was significantly associated with coronary artery calcification, left ventricular hypertrophy and atherosclerosis in HD patients. 相似文献46.
Hanène Ferjani Dorra Ben Nessib Kaouther Maatallah Wafa Triki Dhia Kaffel Wafa Hamdi 《The Egyptian Rheumatologist》2021,43(2):179-181
BackgroundChondrocalcinosis is a metabolic arthropathy rarely affecting the anterior chest wall (ACW).Aim of the workTo report here a case of a polyarticular chondrocalcinosis with an uncommon localization in the sternoclavicular joints (SCJs), revealed by computed tomography (CT).Case reportA 76-year old female presented to the Rheumatology outpatient clinic Kassab orthopedics institute with low back pain. The history goes back to 4 months prior to her presentation when she developed mechanical back pain that progressively worsened during the last month, becoming inflammatory with prolonged morning stiffness. She had no history of fever or weight loss and no symptoms in the cervical spine, shoulders, chest wall, hips or knees. Physical examination revealed limited range of motion of hips, cervical and lumbar spine and bilateral swelling of SCJs without tenderness on pressure or mobilization. Biochemical investigations showed normal levels of inflammatory markers, phosphorus and calcium. Conventional radiographs showed multiple areas of calcification in the intra-vertebral discs, joint space narrowing of sacroiliac (SI) and coxofemoral joints. Chest wall radiograph appeared normal. ACW and pelvic CT were done to further delineate the cause. It showed intra-cartilaginous bilateral calcifications of SCJs, sacroilliac, intervertebral discs, coxofemoral joints and pubic symphysis. The final diagnosis was polyarticular chondrocalcinosis. The patient received analgesics, non-steroidal anti-inflammatory drugs and had functional rehabilitation sessions. Conclusion: This case points to the rare localization of chondrocalcinosis in the SCJ and should be considered especially in an elderly female. Early recognition is necessary in order to initiate an appropriate and prompt treatment. 相似文献
47.
Nedra Touj Abdullah S. Al-Ayed Mathieu Sauthier Lamjed Mansour Abdel Halim Harrath Jamil Al-Tamimi Ismail
zdemir Sedat Yaar Naceur Hamdi 《RSC advances》2018,8(70):40000
N,N-Substituted benzimidazole salts were successfully synthesized and characterized by 1H-NMR, 13C {1H} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 °C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a–i and 4a–i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 μg mL−1 against MDA-MB-231 and 4.85 μg mL−1 against MCF7 respectively.The in situ prepared four component system Pd(OAc)2, 1,3-dialkylbenzimidazolium halides 2a–i and 4a–i, K2CO3 under CO atmosphere catalyses carbonylative cross-coupling reaction of 2-bromopyridine with various boronic acids to yield unsymmetrical arylpyridine ketones. 相似文献
48.
Mohamed M. Awad Feras Alhalabi Abdullah Alshehri Zaid Aljeaidi Ali Alrahlah Mutlu
zcan Hamdi Hosni Hamama 《Materials》2021,14(4)
Objective: The objective of this review was to evaluate the effect of non-thermal atmospheric plasma (NTAP) on adhesives resin–dentin micro-tensile bond strength (μTBS) in previously published studies. Methods: Electronic search was conducted using the Medline, Cochrane library, and Scopus databases. The included studies were laboratory studies that investigated the effect of NTAP on adhesives μTBS to coronal dentin. Studies that evaluated the effect of NTAP on bond strength to indirect substrates, enamel or root dentin, were excluded. The methodological quality of included studies was assessed. Results: Thirteen studies were included in this systematic review. All the included studies were considered to have a medium risk of bias. NTAP significantly improved μTBS at 24 h or after short-term aging in five studies (38.5%) and both immediate and after long-term aging in 5 studies (38.5%). In two studies (15.4%), NTAP resulted in a short-term material-dependent effect that was not stable after long-term aging. Interestingly, in one study (7.7%), NTAP had a positive effect only in the etch-and-rinse (ER) mode after long-term aging. Conclusion: Within the limitations of this systematic review, NTAP application could enhance resin–dentin μTBS of ER adhesives or universal adhesives (UAs) applied in the ER mode. In the ER mode, the rewetting step after NTAP seems to be unnecessary. Because of the limited information currently available in the literature, further studies are required to evaluate the effect of the NTAP application on self-etch (SE) adhesives or UAs applied in the SE mode. 相似文献
49.
Mohamed Elshaer Gianpiero Gravante Yifan Yang Sarah Hudson Katie Thomas Roberto Sorge Salem Al-Hamali Ashish Kelkar Hamdi Ebdewi 《American journal of surgery》2014
Background
Incidental gallbladder cancer (IGC) is an infrequent possibility in patients undergoing cholecystectomies. Routine histologic examination of all gallbladder specimens is the current approach to detect this disease. Our study presents the influence of age to perform a selective histologic analysis.Methods
A retrospective review was conducted of all gallbladder specimens during the last 9 years in our hospital. The medical notes were retrieved for cases of IGC or dysplasia and perioperative data were collected.Results
A total of 3,330 cholecystectomies were conducted over the study period, 3,041 for gallstone disease. Twelve patients were found with dysplasia and 13 patients with IGC, all of them occurred in gallbladders removed for gallstone diseases. There were 18 men with a median age of 65 years (range 18 to 85). Median age for cancer patients was 70 years (range 51 to 85) and 54 years for dysplasia (range 18 to 75). No patient below the age of 51 years (n = 1,464) experienced IGCs.Conclusion
Age should be considered as an additional factor for a selective approach to the histologic analysis of all gallbladder specimens following cholecystectomies. 相似文献50.
Ziadé Nelly Hmamouchi Ihsane el Kibbi Lina Abdulateef Nizar Halabi Hussein Abutiban Fatemah Hamdi Wafa el Rakawi Manal Eissa Mervat Masri Basel 《Clinical rheumatology》2020,39(11):3205-3213
Clinical Rheumatology - To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on rheumatology practice. A cross-sectional web survey was designed by the members of the Arab... 相似文献