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991.
Ohne ZusammenfassungMit 1 Tafel. 相似文献
992.
B Singh M Gilhotra R Smith M Brinsmead T Lewin C Hall 《Journal of affective disorders》1986,11(2):173-177
The hypothesis that post-partum psychoses are predominantly mixed affective disorders was tested by administering the dexamethasone suppression test (DST) to seven puerperal psychotics, six puerperal depressives and comparison groups of non-puerperal psychotic and depressed women. The hypothesis received support from the finding that two-third of the puerperal patients had positive DSTs versus one-third of similar non-puerperal patients. An 80% rate of positive DSTs in 19 normal women 5 days post-partum, however, suggested this was an invalid interpretation of this finding, particularly as the majority of these tests returned to normal when repeated several weeks later. 相似文献
993.
A novel computational fluid dynamic model describing the antigen–antibody binding on an electrode surface is presented. It was assumed that the adsorption rate of the antibody sample is dependent upon the flow field in the vicinity of the electrode. Numerical solution of the steady flow in a two-dimensional triangular cell using the Navier–Stokes equations was carried out for predicting mass adsorption on the surface of the crystal. The relationships between the mass adsorbed over the area surface of the electrode, the kinetics of the binding process, and the flow field were determined. The effect of the inlet conditions (location, velocity magnitude, and direction) on the time constant of the mass adsorption process was investigated. It was found that the time constant was decreased by moving the inlet near the edge of the crystal or increasing the normal to the boundary component of the velocity. These changes may significantly reduce the time needed to conduct the test. © 2000 Biomedical Engineering Society.
PAC00: 8780-y, 8550+k, 8710+e 相似文献
994.
Reaction times (RTs) to words or patterns presented in the left or right visual fields and averaged Event-Related Potentials (ERPs) evoked by the same stimuli presented foveally were measured separately. In both experiments, an oddball paradigm known to elicit the P3 component was used. Twenty-four subjects (12 males) were tested in each experiment. In the electrophysiological study EEG was measured differentially from five different scalp sites, each referred to linked ear lobes. There were two frontal and two parietal lateralized electrodes, and a fifth which was located at the vertex (Cz). The RTs to words were significantly delayed relative to the RTs to patterns. Furthermore, the responses were significantly shorter in the right visual field when the target was a word, yet only slightly shorter in the left visual field when the target was a nonsense pattern. The same pattern of results was found with the evoked potentials: A positive wave evoked by the target stimulus was measured at vertex with mean latency of 511.3 msec in the verbal task, and 464.4 msec in the nonverbal task. At the lateralized locations, a significant Task by Hemisphere interaction was found. When the target was a word the base to peak P3 amplitudes were higher over the left than over the right hemisphere. A reverse trend was found with nonverbal targets. The base to peak P3 amplitudes were slightly (but not significantly) higher over the right than over the left hemisphere. 相似文献
995.
A sister and a brother, offspring of unaffected consanguineous Arab parents, were found to have leukonychia totalis and flat, wide nails. To our knowledge this is the first report of apparent autosomal recessive transmission of this trait. A parental somatic mutation with gonadal mosaicism may explain the unusual segregation of the trait in this family. © 1993 Wiley-Liss, Inc. 相似文献
996.
Avichai Shimoni Moshe Yeshurun Izhar Hardan Abraham Avigdor Isaac Ben-Bassat Arnon Nagler 《Biology of blood and marrow transplantation》2004,10(7):484-493
Thrombotic microangiopathy (TMA) is one of the most severe complications of stem cell transplantation (SCT). Endothelial cell injury caused by the toxic effects of high-dose chemoradiotherapy is likely the primary event in pathogenesis. The incidence, clinical settings, and risk factors for TMA in the era of nonmyeloablative conditioning have not been well defined. The data on 147 consecutive SCTs in a single center were collected, and patients with TMA were identified. Patient characteristics, response to therapy, and outcome were recorded, and risk factors were determined. TMA occurred in 22 of 147 transplantations, with a projected incidence of 20% +/- 4%. TMA occurred in 3 clinical settings: classic multifactorial TMA, TMA associated with severe hepatic graft-versus-host disease (GVHD), and TMA associated with second SCT, with a projected incidence of 8% +/- 3%, 73% +/- 14%, and 70% +/- 16% of patients at risk, respectively. TMA occurred after 23% +/- 6% of nonmyeloablative and 16% +/- 5% of myeloablative conditioning regimens (not significant). Univariate analysis determined SCT from unrelated donors, SCT during advanced or active disease, second SCT within 6 months of a prior SCT, and acute GVHD as risk factors for TMA. The last 2 factors remained significant in a multivariate model. Thirty-two percent of patients responded to therapy. The peri-TMA mortality rate was 68% +/- 10%. Six patients had diffuse alveolar hemorrhage complicating TMA. SCT-associated TMA is a relatively common complication with unsatisfactory therapy and grim prognosis. Fludarabine-based nonmyeloablative conditioning does not confer a lesser risk for TMA. This observation may relate to the selective use of these regimens in elderly and heavily pretreated patients or to the lack of reduction of GVHD with these regimens, and fludarabine itself may be involved in causing endothelial damage. Further exploration of novel preventive and therapeutic measurements is required in high-risk settings. 相似文献
997.
Salla Atkins Simon Lewin Helen Smith Mark Engel Atle Fretheim Jimmy Volmink 《BMC medical research methodology》2008,8(1):21
Background
Qualitative synthesis has become more commonplace in recent years. Meta-ethnography is one of several methods for synthesising qualitative research and is being used increasingly within health care research. However, many aspects of the steps in the process remain ill-defined. 相似文献998.
999.
Delayed lower cranial neuropathy after oropharyngeal intensity‐modulated radiotherapy: A cohort analysis and literature review
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1000.
Julie Ratcliffe Emily Lancsar Thomas Flint Billingsley Kaambwa Ruth Walker Gill Lewin Mary Luszcz Ian D. Cameron 《Quality of life research》2017,26(2):299-309