全文获取类型
收费全文 | 5200篇 |
免费 | 240篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 47篇 |
儿科学 | 123篇 |
妇产科学 | 55篇 |
基础医学 | 569篇 |
口腔科学 | 159篇 |
临床医学 | 358篇 |
内科学 | 1224篇 |
皮肤病学 | 51篇 |
神经病学 | 369篇 |
特种医学 | 200篇 |
外科学 | 898篇 |
综合类 | 19篇 |
预防医学 | 293篇 |
眼科学 | 77篇 |
药学 | 539篇 |
中国医学 | 9篇 |
肿瘤学 | 465篇 |
出版年
2023年 | 23篇 |
2022年 | 42篇 |
2021年 | 92篇 |
2020年 | 45篇 |
2019年 | 61篇 |
2018年 | 74篇 |
2017年 | 74篇 |
2016年 | 74篇 |
2015年 | 69篇 |
2014年 | 110篇 |
2013年 | 154篇 |
2012年 | 217篇 |
2011年 | 271篇 |
2010年 | 135篇 |
2009年 | 86篇 |
2008年 | 190篇 |
2007年 | 226篇 |
2006年 | 206篇 |
2005年 | 236篇 |
2004年 | 217篇 |
2003年 | 193篇 |
2002年 | 210篇 |
2001年 | 203篇 |
2000年 | 190篇 |
1999年 | 185篇 |
1998年 | 62篇 |
1997年 | 56篇 |
1996年 | 56篇 |
1995年 | 48篇 |
1994年 | 55篇 |
1993年 | 54篇 |
1992年 | 171篇 |
1991年 | 166篇 |
1990年 | 140篇 |
1989年 | 128篇 |
1988年 | 119篇 |
1987年 | 104篇 |
1986年 | 111篇 |
1985年 | 110篇 |
1984年 | 60篇 |
1983年 | 59篇 |
1982年 | 30篇 |
1981年 | 28篇 |
1980年 | 23篇 |
1979年 | 44篇 |
1975年 | 23篇 |
1974年 | 27篇 |
1971年 | 21篇 |
1969年 | 20篇 |
1968年 | 20篇 |
排序方式: 共有5455条查询结果,搜索用时 406 毫秒
131.
Maki Komiyama Yuka Ozaki Yusuke Miyazaki Akihiro Yasoda Hiromichi Wada Hajime Yamakage Noriko Satoh-Asahara Tatsuya Morimoto Akira Shimatsu Yuko Takahashi Koji Hasegawa 《Internal medicine (Tokyo, Japan)》2021,60(8):1175
Objective The psychological status is a key factor in smoking continuance. However, details on short-term changes in mild depressive states after smoking cessation (SC) are still unknown. The purpose of the present study was to investigate these short-term changes. Methods A total of 989 patients who visited our SC Clinic were assessed using the Zung Self-Rating-Depression-Scale (SDS), an official instrument to measure depressive tendencies. The participants were classified into normal and neurotic groups based on their SDS scores during their initial visit; they were assessed again 2, 4, 8, and 12 weeks thereafter. Results The majority of patients in the neurotic group were women. These patients were also younger, with a higher nicotine dependence, and presented with a lower successful SC rate than the patients in the normal group. A decrease in SDS scores after starting the SC treatment was observed only in the neurotic group, especially during the first two weeks. In patients who continued to smoke, no improvement in depressive tendencies was noted in this period. Conclusion Depressive tendencies of patients with neurosis improve in the initial stages of the SC treatment (i.e., within two weeks after starting the treatment). This finding fills the mentioned knowledge gap regarding the effects of SC on mild depressive states in the short term. 相似文献
132.
Miwa Kawanaka Ken Nishino Yumiko Morimoto Katsunori Ishii Tomohiro Tanikawa Noriyo Urata Mitsuhiko Suehiro Takako Sasai Ken Haruma Hirofumi Kawamoto 《Internal medicine (Tokyo, Japan)》2021,60(9):1397
A 44-year-old patient progressed from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) cirrhosis. She was diagnosed with NAFL via a liver biopsy. At 56 years old, she was diagnosed with NASH stage 3 via a second liver biopsy. One year later, she was diagnosed with NASH cirrhosis via a third liver biopsy. This is the first study to report the gradual deterioration of liver histology shown via three liver biopsies and fibrosis markers in a patient who progressed from NAFL to NASH cirrhosis. Following menopause, it is necessary to be aware of the rapid development of liver fibrosis. 相似文献
133.
Takeru Sakai Kazuki Aoyama Koji Inazumi Rieko Kikuchi Yuki Sato Ai Tada Takumi Hirata Jiro Morimoto 《Journal of diabetes and its complications》2021,35(8):107962
AimsTime in range (TIR), an index of glycemic control and also blood glucose fluctuation, obtained from continuous glucose monitoring (CGM), has been increasing its importance along with the spread of CGM in recent years. For a while, glycated albumin (GA) has been also used as a glycemic control index during about 2-weeks in routine clinical practice. It has not yet been confirmed under optimal condition whether TIR and GA correlates. Clarification of the correlation between TIR and GA, which was measured immediately after 2-weeks of CGM, might be a finding that further supports the utility of TIR.MethodsGA was measured at the conclusion of 2-week CGM in 71 diabetes outpatients at our hospital, and the correlation between GA and indices such as TIR obtained from CGM was statistically analyzed.ResultsIt was found that TIR and time above range (TAR) were significantly correlated with GA. Upon performing multiple regression analysis, TIR, TAR and BMI. indicated a significant regression coefficient with respect to GA.ConclusionsThese findings further support the utility of TIR as a marker of glycemic control that it might also be correlated with GA, and also suggest a relation between GA and blood glucose fluctuation. 相似文献
134.
Mori K Yoshihara T Nishimura Y Uchida M Katsura K Kawase Y Hatano I Ishida H Chiyonobu T Kasubuchi Y Morimoto A Teramura T Imashuku S 《Bone marrow transplantation》2003,31(12):1173-1176
Management of post-transplant complications caused by severe adenoviral infection remains a major therapeutic challenge. A 17-year-old male who had undergone bone marrow transplantation for the treatment of acute lymphoblastic leukemia developed complete anuria following hemorrhagic cystitis 34 days after the transplant procedure. The computed tomogram scan revealed bilateral hydronephrosis, indicating acute renal failure because of obstructive uropathy. The emergency procedure of percutaneous nephrostomy caused massive bleeding in the left kidney, which eventually required a nephrectomy. Adenovirus-positive severe necrotizing tubulointerstitial nephritis was the histopathological diagnosis. Post-transplant acute renal failure because of hydronephrosis, which could be complicated by adenovirus-induced renal parenchymal disease, is of great concern and may cause significant problems with interventional treatment. 相似文献
135.
T. Takeda N. Morimoto N. Kinukawa R. Nagamine T. Shuto Y. Iwamoto H. Miyahara 《Modern rheumatology / the Japan Rheumatism Association》2000,10(4):240-246
We attempted to identify which background factors were the most important indicators of such psychological problems as emotional
instability, a feeling of hopelessness, and suicidal tendencies in female rheumatoid arthritis (RA) outpatients with limited
functional disorder. Among female RA patients aged 20 years and older who visited the outpatient clinic, 101 class I and II
patients were selected as subjects for the present study. An original questionnaire and a psychological test (CMI) were given
to those subjects who had given their written consent to such testing, and an analysis was carried out on 85 patients who
returned all the written forms. Their emotional instability was related to factors such as "not being able to understand the
nature of RA disease and its treatment," "sense of value had changed after developing RA," "nonuse of drugs," and "duration
of disease." A feeling of hopelessness was related to "smoking," and a suicidal tendency was related to "smoking" and "class
I." We identified a characteristic correlation between emotional instability and background factors in this study. Paying
close attention to these factors may thus be useful in preventing the appearance of psychological problems as well as in developing
effective early treatment strategies.
Received: April 5, 2000 / Accepted: July 19, 2000 相似文献
136.
Naito Y Tsujino T Kawasaki D Okumura T Morimoto S Masai M Sakoda T Fujioka Y Ohyanagi M Iwasaki T 《Journal of hypertension》2003,21(6):1107-1115
137.
K Uchida S Azukizawa N Imaizumi T Kigoshi I Yamamoto H Hosojima S Morimoto 《Acta endocrinologica》1986,111(2):222-227
To assess the nature of the heparin-induced aldosterone deficiency, we investigated the stimulatory effect of angiotensin II (AII) on aldosterone and its precursor steroids in adrenal zona glomerulosa cells from heparin-treated rats compared with those in the cells from vehicle-treated rats. Heparin-treated rats had low plasma aldosterone levels, high plasma renin activity and plasma AII levels, and normal plasma corticosterone level 6 weeks after the treatment (1500 IU/kg, twice daily). Basal aldosterone production, when corrected to a uniform number of cells per group, was similar in the cells from heparin- and vehicle-treated rats. The cells from heparin-treated rats had a less sensitive and lower response of aldosterone production to AII; an increase by 4 orders of magnitude in the threshold dose for AII and a decrease in the maximum AII-stimulated level. The maximum AII-stimulated levels, but not the basal levels, of pregnenolone, corticosterone and 18-OHB production were low in the cells from heparin-treated rats. ACTH caused a similar stimulatory effect on aldosterone production in the cells from heparin- and vehicle-treated rats. The cells from heparin-treated rats had a less sensitive and lower response of aldosterone production to potassium; an increase by one order of magnitude in the threshold dose for potassium and a decrease in the maximum potassium-stimulated level, presumably because of the glomerulosa hyporesponsiveness to AII. These results suggest that our heparin-treated rats have selective impairment of adrenal zona glomerulosa cells, involving the specific receptors and the aldosterone biosynthesis, to AII. 相似文献
138.
M. Kuriyama J. Kato N. Morimoto T. Fujimoto H. Okada K. Yamamoto 《Digestive and liver disease》2008,40(6):468-475
BACKGROUND: Crohn's disease patients often carry gastroduodenal lesions. However, few reports have addressed specific gastroduodenoscopic findings in Crohn's disease patients. METHODS: The gastroduodenoscopic findings of 63 Crohn's disease patients were examined. Those of 62 ulcerative colitis and 63 age- and gender-matched gastroesophageal reflux disease patients were also reviewed as controls. Findings of bamboo-joint-like appearance, gastric antral erosions, and duodenal lesions were the specific findings that were highlighted. RESULTS: Of 63 Crohn's disease patients, 47 (75%) had at least one of the specific gastroduodenoscopic findings, and the prevalence of these findings was significantly higher in Crohn's disease patients than in ulcerative colitis and gastroesophageal reflux disease patients (ulcerative colitis, 24/62, 39%; gastroesophageal reflux disease, 15/63, 24%, P < 0.0001). In particular, bamboo-joint-like appearance was almost unique to Crohn's disease patients (Crohn's disease, 28/63, 44%; ulcerative colitis, 3/62, 5%; gastroesophageal reflux disease, 0/63, 0%, P < 0.0001). Analysis of the relationship between the Crohn's disease patient's background and gastrodunodenoscopic findings revealed that both patients with disease affecting the ileum and those with previous gut operations were more likely to exhibit the specific gastroduodenoscopic findings (P = 0.030 and P = 0.043, respectively). CONCLUSION: Specific gastroduodenoscopic findings were observed in Crohn's disease patients. In particular, bamboo-joint-like appearance could be a unique marker of Crohn's disease. 相似文献
139.
Tatsuya Takeshita Kanehisa Morimoto 《Alcoholism, clinical and experimental research》1998,22(7):1409-1413
Nearly half of all Orientals exhibit aversive symptoms, such as "Oriental flushing" or palpitation, during alcohol consumption. This high alcohol sensitivity among Orientals has been attributed to a highly prevalent polymorphism in low Km aldehyde dehydrogenase (ALDH2). In the present study, we attempted to develop a reliable questionnaire method to probe the frequency of alcohol drinking-related symptoms to estimate the ALDH2 genotype. Four-hundred twenty-four male and 100 female workers provided blood samples for polymerase chain reaction analysis and completed the questionnaire. We performed a stepwise logistic regression analysis to discriminate between the typical homozygote ( ALDH2*1/*1 ) and the atypical heterozygote ( ALDH2*1/*2 ) in male subjects. Because of the limitation in the sample size for ALDH2*2/*2 , this genotype was not included in the analysis. Results revealed that only three symptoms (facial flushing, flushing elsewhere, and palpitation) were enough to correctly predict the ALDH2 genotypes in ∼89% of all subjects. The present questionnaire method ( AL cohol Sensitivity screening Test; ALST) takes a little time and effort for the genotype determination, and may be especially useful in epidemiological studies with a large sample size or with subjects from whom DNA samples are not available. 相似文献
140.
Morimoto S Komatsu S Takahashi R Matsuo M Goto S 《Archives of gerontology and geriatrics》1993,16(3):217-224
We investigated age-related changes in the ubiquitination of histones in mouse brains. By Western blot analysis using rabbit anti-ubiquitin antibodies, histone H2A and H2B were found to be the only proteins that are ubiquitinated in the acid-extractable nuclear proteins of both young (4-month-old) and senescent (29-month-old) mouse brains. The proportion of ubiquitinated histones was about 30% higher in senescent mice than in young ones. When total brain homogenates were analyzed similarly using somewhat different age groups of the animals, the proportion in the old animals was about 2-fold higher than that in the young. 相似文献