全文获取类型
收费全文 | 63916篇 |
免费 | 3700篇 |
国内免费 | 344篇 |
专业分类
耳鼻咽喉 | 570篇 |
儿科学 | 1620篇 |
妇产科学 | 1592篇 |
基础医学 | 8492篇 |
口腔科学 | 1293篇 |
临床医学 | 5647篇 |
内科学 | 14325篇 |
皮肤病学 | 1150篇 |
神经病学 | 6587篇 |
特种医学 | 2291篇 |
外科学 | 8914篇 |
综合类 | 255篇 |
一般理论 | 24篇 |
预防医学 | 3930篇 |
眼科学 | 1153篇 |
药学 | 3969篇 |
1篇 | |
中国医学 | 105篇 |
肿瘤学 | 6042篇 |
出版年
2023年 | 535篇 |
2022年 | 978篇 |
2021年 | 2100篇 |
2020年 | 1224篇 |
2019年 | 1714篇 |
2018年 | 1984篇 |
2017年 | 1428篇 |
2016年 | 1598篇 |
2015年 | 1832篇 |
2014年 | 2494篇 |
2013年 | 3135篇 |
2012年 | 4727篇 |
2011年 | 4720篇 |
2010年 | 2420篇 |
2009年 | 2250篇 |
2008年 | 3806篇 |
2007年 | 3824篇 |
2006年 | 3492篇 |
2005年 | 3424篇 |
2004年 | 2966篇 |
2003年 | 2734篇 |
2002年 | 2577篇 |
2001年 | 879篇 |
2000年 | 880篇 |
1999年 | 891篇 |
1998年 | 549篇 |
1997年 | 417篇 |
1996年 | 392篇 |
1995年 | 364篇 |
1994年 | 341篇 |
1993年 | 293篇 |
1992年 | 710篇 |
1991年 | 620篇 |
1990年 | 602篇 |
1989年 | 594篇 |
1988年 | 534篇 |
1987年 | 513篇 |
1986年 | 462篇 |
1985年 | 467篇 |
1984年 | 282篇 |
1983年 | 224篇 |
1982年 | 128篇 |
1981年 | 105篇 |
1979年 | 238篇 |
1978年 | 137篇 |
1977年 | 111篇 |
1975年 | 104篇 |
1974年 | 101篇 |
1970年 | 102篇 |
1969年 | 118篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
61.
62.
N Mori 《Nihon Shokakibyo Gakkai zasshi》1987,84(5):1057-1067
63.
64.
Anthony Spirito Larry Brown James Overholser Gregory Fritz Andrea Bond 《Death Studies》1991,15(3):269-280
The assessment of the medical lethality and intent of suicide attempts has been considered an important area of research for those interested in suicide. The current study examined the usefulness of the Risk-Rescue Rating Scale with 109 adolescent suicide attempters and found a restricted range of variability, which, in turn, resulted in poor interrater reliability on a number of items. Results suggest that the Risk-Rescue Rating Scale is of limited usefulness with adolescents, and alternative approaches to assessing lethality and suicidal intent with this age group are discussed. 相似文献
65.
Effect of the free radical scavenger MCI-186 on spinal cord reperfusion after transient ischemia in the rabbit 总被引:4,自引:0,他引:4
Kenichi Hashizume Toshihiko Ueda Hideyuki Shimizu Atsuo Mori Ryohei Yozu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(8):426-433
Objective: Paraplegia remains a serious complication of aortic operations. The production of free radicals during reperfusion
after transient ischemia is believed to induce secondary spinal neuronal injury, resulting in paraplegia. The aim of the present
study was to clarify the protective effect and method of administration of antioxidants on the neurological and histological
outcome in the animal model for reperfusion injury after transient spinal cord ischemia. Methods: New Zealand white rabbits underwent surgical exposure of the abdominal aorta that was clamped for 15 minutes to achieve spinal
cord ischemia. Group A animals received two 10 mg/kg doses of 3-methyl-l-phenyl-2-pyrazolin-5-one (MCI-186) at the time of
release of the aortic clamp and 30 minutes later. In group B, MCI-186, 5 mg/kg, was given three times, at the time of aorta
clamp release, 30 minutes and 12 hours later. In group C (control group), one dose of vehicle was administered. Neurological
status was assessed using modified Tarlov’s score until 168 hours after operation. Spinal cord sections were examined microscopically
to determine the extent of ischemic neuronal damage. Results: Groups A and B animals had better neurological function than group C (p(0.001). In contrast, group C animals exhibited paraplegia or paraparesis with marked neuronal necrosis. The number of surviving
neurons within examined sections of the spinal cord was significantly greater in group B than in group C (p(0.001). Conclusion: In a 15-minute ischemia-reperfusion model using rabbits, systemic repetitious administration of MCI-186, a free radical scavenger,
was found to have a protective effect on the spinal cord neurons both neurologically and histologically. We postulate that
the drug minimizes the delayed neuronal cell death for reperfusion injury after transient ischemia by reducing the free radical
molecules. Moreover, it was thought that we could protect delayed neuronal cell death more effectively by administering MCI-18612
hours later. 相似文献
66.
67.
Andrea Salonia MD Alberto Briganti MD Andrea Gallina MD Giuseppe Zanni MD Federico Dehò MD Patrizio Rigatti MD Francesco Montorsi MD 《Current Sexual Health Reports》2007,4(2):85-90
This article assesses the effects of lower urinary tract symptoms (LUTS), not including urinary incontinence, on the overall
sexual health of women, using literature that includes peer-reviewed articles. This article analyzes a number of studies that
provide data on the prevalence and the predictors of sexual function impairment in women with LUTS, such as urinary urgency
and frequency, overactive bladder syndrome, and interstitial cystitis. Because case studies provide substantial heterogeneity
of outcome measures, this article does not apply meta-analytic techniques to the data. Most of the studies showed that LUTS
can have a negative impact on the sexual health of women, sexual pain disorder being the more frequent complaint among patients
with bladder dysfunctions. 相似文献
68.
Antonio Gigante Claudia Bevilacqua Andrea Ricevuto Monica Mattioli-Belmonte Francesco Greco 《Knee surgery, sports traumatology, arthroscopy》2007,15(1):88-92
The implantation of chondrocytes, seeded on matrices such as hyaluronic acid or collagen membranes, is a method that is being widely used for the treatment of chondral defects. The aim of the present study was to evaluate the distribution, viability and phenotype expression of the cells seeded on a collagen membrane just at the time of the implantation. Twelve patients who were suffering from articular cartilage lesions were treated by the MACI® procedure. The residual part of each membrane was tested by colorimetric assay (MTT) and histochemical and ultrastructural analyses were carried out. In all of the samples a large number of viable cells, quite homogenously distributed, was detected. The cells expressed the markers of the differentiated hyaline chondrocytes. These data reassure in that the MACI procedure provides a suitable engineered tissue for cartilage repair, in line with the clinical evidences emerging in the literature. 相似文献
69.
Andrea Berger Michelle Sadeh Gabriel Tzur I Avinoam Shuper Liora Kornreich Dov Inbar Ian J Cohen Shalom Michowiz Isaac Yaniv Shlomi Constantini Eli Vakil 《Journal of the International Neuropsychological Society》2005,11(4):482-487
Cerebellar involvement in motor and non-motor sequence learning was examined with serial reaction time tasks (SRT). Our sample consisted of 8 children and adolescents who had undergone surgical removal of a benign posterior fossa tumor (PFT) during childhood. None of them had undergone chemotherapy or cranial radiation therapy (CRT). Ages ranged from 1-11 years at surgery and 9-17 years at testing. The children were tested not earlier than 2.5 years after surgery (M = 5.9 years), enabling brain plasticity and recovery of functions. Their performance was compared with a matched control sample. The PFT group was not impaired in the implicit learning of sequences, as reflected in their performance in blocks with a repeated sequence, both before and after a random block. However, in the perceptual task, their performance deteriorated more than that of the control group when a random block was introduced, suggesting that it was more difficult for the patients to respond flexibly or change their response set when encountering changing task demands. These results are in line with another study by our group on task switching with the same patients. 相似文献
70.
Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. 总被引:8,自引:0,他引:8
Barbara M Obermayer-Pietsch Christine M Bonelli Daniela E Walter Regina J Kuhn Astrid Fahrleitner-Pammer Andrea Berghold Walter Goessler Vinzenz Stepan Harald Dobnig Georg Leb Wilfried Renner 《Journal of bone and mineral research》2004,19(1):42-47
Evidence that genetic disposition for adult lactose intolerance significantly affects calcium intake, bone density, and fractures in postmenopausal women is presented. PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify persons at risk for both lactose malabsorption and osteoporosis. INTRODUCTION: Lactase deficiency is a common autosomal recessive condition resulting in decreased intestinal lactose degradation. A -13910 T/C dimorphism (LCT) near the lactase phlorizin hydrolase gene, reported to be strongly associated with adult lactase nonpersistence, may have an impact on calcium supply, bone density, and osteoporotic fractures in the elderly. MATERIALS AND METHODS: We determined LCT genotypes TT, TC, and CC in 258 postmenopausal women using a polymerase chain reaction-based assay. Genotypes were related to milk intolerance, nutritional calcium intake, intestinal calcium absorption, bone mineral density (BMD), and nonvertebral fractures. RESULTS: Twenty-four percent of all women were found to have CC genotypes and genetic lactase deficiency. Age-adjusted BMD at the hip in CC genotypes and at the spine in CC and TC genotypes was reduced by -7% to -11% depending on the site measured (p = 0.04). LCT(T/C-13910) polymorphisms alone accounted for 2-4% of BMD in a multiple regression model. Bone fracture incidence was significantly associated with CC genotypes (p = 0.001). Milk calcium intake was significantly lower (-55%, p = 0.004) and aversion to milk consumption was significantly higher (+166%, p = 0.01) in women with the CC genotype, but there were no differences in overall dietary calcium intake or in intestinal calcium absorption test values. CONCLUSION: The LCT(T/C-13910) polymorphism is associated with subjective milk intolerance, reduced milk calcium intake, and reduced BMD at the hip and the lumbar spine and may predispose to bone fractures. Genetic testing for lactase deficiency may complement indirect methods in the detection of individuals at risk for both lactose malabsorption and osteoporosis. 相似文献