全文获取类型
收费全文 | 1628篇 |
免费 | 108篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 24篇 |
妇产科学 | 8篇 |
基础医学 | 211篇 |
口腔科学 | 33篇 |
临床医学 | 149篇 |
内科学 | 397篇 |
皮肤病学 | 44篇 |
神经病学 | 105篇 |
特种医学 | 161篇 |
外科学 | 223篇 |
综合类 | 68篇 |
预防医学 | 74篇 |
眼科学 | 13篇 |
药学 | 122篇 |
1篇 | |
中国医学 | 35篇 |
肿瘤学 | 67篇 |
出版年
2023年 | 12篇 |
2022年 | 31篇 |
2021年 | 38篇 |
2020年 | 36篇 |
2019年 | 35篇 |
2018年 | 44篇 |
2017年 | 32篇 |
2016年 | 46篇 |
2015年 | 78篇 |
2014年 | 76篇 |
2013年 | 105篇 |
2012年 | 125篇 |
2011年 | 118篇 |
2010年 | 98篇 |
2009年 | 87篇 |
2008年 | 83篇 |
2007年 | 88篇 |
2006年 | 72篇 |
2005年 | 77篇 |
2004年 | 48篇 |
2003年 | 47篇 |
2002年 | 54篇 |
2001年 | 16篇 |
2000年 | 6篇 |
1999年 | 9篇 |
1998年 | 31篇 |
1997年 | 26篇 |
1996年 | 29篇 |
1995年 | 27篇 |
1994年 | 24篇 |
1993年 | 15篇 |
1992年 | 3篇 |
1991年 | 2篇 |
1990年 | 6篇 |
1989年 | 17篇 |
1988年 | 17篇 |
1987年 | 12篇 |
1986年 | 9篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1977年 | 2篇 |
1976年 | 12篇 |
1975年 | 5篇 |
1954年 | 1篇 |
排序方式: 共有1760条查询结果,搜索用时 31 毫秒
71.
Neuroprotection of posttreatment with risperidone,an atypical antipsychotic drug,in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke 下载免费PDF全文
Ji Hyeon Ahn In Hye Kim Ok Kyu Park Jae‐Chul Lee Ki‐Yeon Yoo Jung Hoon Choi Choong Hyun Lee In Koo Hwang Jeong Ho Park Song Her Jin Su Kim Hyung‐Cheul Shin Jun Hwi Cho Young‐Myeong Kim Seung‐Hae Kwon Moo‐Ho Won 《Journal of neuroscience research》2014,92(6):795-807
Risperidone, an atypical antipsychotic drug, has been discovered to have some beneficial effects beyond its original effectiveness. The present study examines the neuroprotective effects of risperidone against ischemic damage in the rat and gerbil induced by transient focal and global cerebral ischemia, respectively. The results showed that pre‐ and posttreatment with 4 mg/kg risperidone significantly protected against neuronal death from ischemic injury. Many NeuN‐immunoreactive neurons and a few F‐J B‐positive cells were found in the rat cerebral cortex and gerbil hippocampal CA1 region (CA1) in the risperidone‐treated ischemia groups compared with those in the vehicle‐treated ischemia group. In addition, treatment with risperidone markedly attenuated the activation of microglia in the gerbil CA1. On the other hand, we found that treatment with risperidone significantly maintained the antioxidants levels in the ischemic gerbil CA1. Immunoreactivities of superoxide dismutases 1 and 2, catalase, and glutathione peroxidase were maintained in the stratum pyramidale of the CA1; the antioxidants were very different from those in the vehicle‐treated ischemia groups. In brief, our present findings indicate that posttreatment as well as pretreatment with risperidone can protect neurons in the rat cerebral cortex and gerbils CA1 from transient cerebral ischemic injury and that the neuroprotective effect of risperidone may be related to attenuation of microglial activation as well as maintenance of antioxidants. © 2014 Wiley Periodicals, Inc. 相似文献
72.
Tracy-Ann Moo MD Lydia Choi MD Candice Culpepper MD Cristina Olcese BS Alexandra Heerdt MD Lisa Sclafani MD Tari A. King MD Anne S. Reiner MPH Sujata Patil PhD Edi Brogi MD Monica Morrow MD Kimberly J. Van Zee MS MD 《Annals of surgical oncology》2014,21(1):86-92
Background
For breast-conserving surgery, the method of margin assessment that most frequently achieves negative margins without increasing the volume of tissue excised is uncertain. We examined our institutional experience with three different margin assessment methods used by six experienced breast surgeons.Methods
Patients undergoing breast-conserving surgery for invasive carcinoma during July to December of a representative year during which each method was performed (perpendicular, 2003; tangential, 2004; cavity shave, 2011) were included. The effect of margin method on the positive margin rate at first excision and the total volume excised to achieve negative margins were evaluated by multivariable analysis, by surgeon, and by tumor size and presence of extensive intraductal component (EIC).Results
A total of 555 patients were identified, as follows: perpendicular, 140; tangential, 124; and cavity shave, 291. The tangential method had a higher rate of positive margins at first excision than the perpendicular and cavity-shave methods (49, 15, 11 %, respectively; p < 0.0001). Median volumes to achieve negative margins were similar (55 ml perpendicular; 64 ml tangential; 62 ml cavity shave; p = 0.24). Four of six surgeons had the lowest rate of positive margins with the cavity-shave method, which was significant when compared to the tangential method (p < 0.0001) but not the perpendicular method (p = 0.37). The volume excised by the three methods varied by surgeon (p < 0.0001). The perpendicular method was optimal for T1 tumors without EIC; the cavity-shave method tended to be superior for T2–T3 tumors and/or EIC.Conclusions
Although the cavity-shave method may decrease the rates of positive margins, its effect on volume is variable among surgeons and may result in an increase in the total volume excised for some surgeons and for small tumors without EIC. 相似文献73.
74.
BackgroundSince margin-negative resection is essential for the cure of pancreatic cancer (PC), early detection of PC is important. Although PC is the third most common cancer associated with BRCA1/2 mutations, clinical research regarding BRCA mutations in resected PC are rare. In this study, we investigated the oncologic characteristics of resected PC with BRCA mutation to suggest management strategies.MethodsWe retrospectively reviewed data from 493 patients who were confirmed to be pathogenic BRCA1/2 mutation carriers between January 2007 and December 2019. We investigated the oncologic characteristics of PC patients by comparing them with resected sporadic PC and other BRCA-related cancer groups (breast cancer, ovarian cancer, and others).ResultsTen BRCA mutation carriers (2.0%) experienced PC, and PC onset was significantly later than that of BRCA-related breast cancer (age: breast vs. pancreas, 45.0 vs. 53.5 years, p = 0.050). Six patients underwent pancreatectomy and their long-term survival outcomes did not differ from those of sporadic PC patients (disease free survival: BRCA1/2 vs. sporadic, 10.0 months vs. 9.0 months, p = 0.504; overall survival: BRCA1/2 vs. sporadic, 29.0 months vs. 35.0 months, p = 0.520).ConclusionBRCA-mutated PC occurs later than BRCA-mutated breast cancer. Active genetic testing to identify BRCA1/2 mutation carriers at the onset of breast cancer and continuous long-term surveillance of these patients can provide opportunities to detect BRCA-mutated PC at a resectable stage. 相似文献
75.
Serologic studies using four murine monoclonal antibodies specific for the common acute lymphoblastic leukemia antigen (CALLA) and five monoclonal antibodies specific for the gp24 surface antigen indicate that these leukemia-associated antigens are present on cells of comparable tissues in man and in four nonhuman primates. As in man, adherent cell populations obtained from skin, lung, and bone marrow of Macaca fascicularis, M mulatta, M nemestrina, and Papio cynocephalus react with these antibodies. Similarly, granulocytes from both man and these nonhuman primates bind CALLA- and gp24-specific antibodies. Radioimmune precipitation experiments confirm the identity of these antigens. Our studies suggest that nonhuman primates can be used to screen serologic reagents to leukemia-associated antigens for potential toxic effects on normal tissues prior to their use in man. Similarly, nonhuman primates could be employed to assess the possible role of antigen-positive stromal cells in the reconstitution of bone marrow following transplantation. 相似文献
76.
Soe Hee Ann Cai De Jin Gillian Balbir Singh Kyung Hun Lim Jae-Wook Chung Scot Garg Moo Hyun Kim Wang-Soo Lee Kyoung Im Cho Sang Wook Kim Eun-Seok Shin 《Heart and vessels》2016,31(11):1767-1775
There is limited research on plaque characteristics of ST elevation myocardial infarction (STEMI) patients according to the gender and age. 280 Consecutive STEMI patients who underwent VH-IVUS imaging on culprit before percutaneous coronary intervention (PCI) were enrolled in this study. Women were significantly older than men (69.8 ± 10 vs. 55.9 ± 11.3, p < 0.001). After propensity matching, men had higher plaque burden (79.7 ± 7.8 vs. 73.7 ± 13.0 %, p = 0.010), more fibro-fatty tissue (12.8 ± 9.9 vs. 9.5 ± 6.8 %, p = 0.04) and less dense calcium than women (8.4 ± 5.8 vs. 12.3 ± 8.7 %, p = 0.007). Subgroups dividing by 50, 65, 75 years old, plaque burden was higher in elderly men aged 66–75 years compared to the young men aged less than 50 (75.5 ± 9.2 vs. 68.4 ± 10.1 %, p = 0.012). And middle aged men ranged 51–65 years showed significantly more plaque burden at minimal lumen area site than matched aged women (77.5 ± 8.0 vs. 69.0 ± 17.6 %, p = 0.012). Elderly women aged 66–75 years showed significantly more necrotic core (28.6 ± 7.3 %) and dense calcium (14.9 ± 7.5 %) compared to all the younger or matched subgroups of men. These differences in plaque composition are blunted in the very elderly of men and women aged over 75 years. The findings may explain the gender differences in clinical prognosis in STEMI patients. 相似文献
77.
目的 :了解我国卫生应急人员对突发公共卫生事件风险评估的认知状况,从文化程度、职称情况、单位性质、单位级别等方面进行比较,为提高卫生应急人员风险评估的认识和能力提供依据。方法 :采用问卷调查的方法,对全国(大陆地区)31个省(自治区、直辖市)承担突发公共卫生事件应急处置的卫生应急工作人员进行调查。采用描述性分析和χ2检验对调查数据进行分析。结果 :我国卫生应急人员对风险评估概念熟悉程度较低,且不同学历、不同职称、不同工作年限、不同机构、不同层级之间的认知存在一定差异;对风险评估工作内容的认知也存在分歧。结论 :应加强风险评估培训,健全风险评估制度,以全面提高卫生应急人员对风险评估的认知水平。 相似文献
78.
79.
80.
Kwang Kyoun Kim Ye Yeon Won Youn Moo Heo Dae Hee Lee Jeong Yong Yoon Won Sub Sung 《Clinics in Orthopedic Surgery》2014,6(1):43-48