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991.
Vaidya D Szklo M Ding J Tracy R Liu K Saad M Ouyang P 《Metabolic syndrome and related disorders》2007,5(4):343-352
Background: The metabolic syndrome (MetS) is a cluster of abnormalities that increases cardiovascular risk. Two different current clinical definitions of MetS, World Health Organization (WHO) and National Cholesterol Education Program (NCEP) Adult Treatment Panel 3 (ATPIII) may differ in association with the atherosclerotic process. We quantified the agreement between the WHO and NCEP definitions and their association with subclinical atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: We analyzed 2601 Caucasian-Americans (C), 800 Chinese-Americans (Ch), 1864 African-Americans (A), and 1483 Hispanic-Americans (H) with complete data for MetS classification from the baseline of the population-based study MESA. Coronary artery calcification (CAC, Agatston score) was quantified by electron beam or helical computed tomography (CT), and intimal-medial thickness of internal and common carotid arteries (IIMT, CIMT) by B-mode ultrasound. Results: The percentage positive agreement differed by ethnicity (Men: C, 65%; Ch, 58%; B, 67%; H, 74%. Women: C, 58%; Ch, 67%; A, 69%; H, 71%; P < .001). Fasting insulin measurement added to the association of the NCEP definition with presence of CAC (P < .001) and CIMT (P < .001, men; P < .002, women), while the waist-hip ratio metric of obesity adds to the association with CIMT (P < .001, men; .003, women). The NCEP threshold for low HDL was associated with CIMT independent of the WHO definition (men, P = .035; women, P = .043). These independent associations did not differ by ethnicity. Conclusion: Metabolic risk factors that differ between the NCEP and WHO MetS definitions are useful in combination to assess the presence of subclinical atherosclerosis. 相似文献
992.
993.
Musumeci O Aguennouz M Comi GP Rodolico C Autunno M Bordoni A Baratta S Taroni F Vita G Toscano A 《Neuromuscular disorders : NMD》2007,17(11-12):960-963
Carnitine palmitoyltransferase 2 (CPT2) deficiency is the most common defect of mitochondrial fatty acid oxidation; three different clinical phenotypes have been described but the adult form, involving exclusively the skeletal muscle, is the most frequent. We describe herein 3 families where 4 individuals manifested with the adult form of CPT2 deficiency. CPT2 gene molecular analysis identified the homozygous R631C mutation, so far only reported in severe infantile cases. Our data evidenced that R631C mutation is not exclusively detected in the infantile form but it may be present in a wider spectrum of CPT2 phenotypes. These findings indirectly suggest that other modulators may influence clinical severity of CPT2 deficiency. 相似文献
994.
995.
Al-Khuwaitir TS Mohammed HB Al-Ghamdi AG Rzayev RA 《Neurosciences (Riyadh, Saudi Arabia)》2007,12(4):330-332
The spinal cord can be involved in a variety of disease processes. These can be congenital or acquired. An acute onset of symptoms usually allows a defined set of causes to be considered including trauma, ruptured vascular anomalies, demyelination, and myelitis. Intramedullary cavernous hemangioma of the spinal cord is a congenital or acquired vascular malformation, and one of the rare causes of hematomyelia. We present such a case, and discuss the symptoms, diagnosis, and suggested best treatment options based on a review of present day literature. 相似文献
996.
997.
Al-Jumaily M Kozlenkov A Mechaly I Fichard A Matha V Scamps F Valmier J Carroll P 《神经科学通报》2007,23(5):293-299
目的在背根神经节(dorsalrootganglion,DRG)中等大小感觉神经元中可以观察到钙激活氯离子流(ICl(Ca))。在坐骨神经损伤模型中,在大多数大中神经元上诱导出类似的氯离子流。本文旨在探讨引起这个离子流的分子基础。方法使用常规的定量RT-PCR方法检测在DRG中三个基因家族的表达,这三个基因家族都具有诱导,ICl(Ca)的特点。结果在成年小鼠的DRG中,分别显示了在正常状态和坐骨神经损伤3天后CLCA,Bestrophin和Tweety基因家族成员的转录产物。结论mBestl和Tweety2可能在损伤诱导的DRG神经元,ICl(Ca)中发挥作用。 相似文献
998.
Saboory E Derchansky M Ismaili M Jahromi SS Brull R Carlen PL El Beheiry H 《Anesthesia and analgesia》2007,105(6):1729-35, table of contents
999.
Hamdulay ZA Kumar P Ali M Bhojraj SS Jain SB Patwardhan AM 《The Annals of thoracic surgery》2007,83(6):2222-2224
We describe an unusual case of a young man presenting with calcific constrictive pericarditis. The patient had a history of restrictive cardiomyopathy and pericardial effusion during infancy and received antituberculous treatment. Investigations revealed the presence of thickened pericardium and a thickened calcific constrictive band around the atrioventricular groove posteriorly and over the infundibulum anteriorly. Intraoperatively, the band caused the heart to have a "dumbbell" appearance. A pericardiectomy was performed along with excision of the constricting band. The patient had an uneventful recovery. 相似文献
1000.
Iyengar SK Abboud HE Goddard KA Saad MF Adler SG Arar NH Bowden DW Duggirala R Elston RC Hanson RL Ipp E Kao WH Kimmel PL Klag MJ Knowler WC Meoni LA Nelson RG Nicholas SB Pahl MV Parekh RS Quade SR Rich SS Rotter JI Scavini M Schelling JR Sedor JR Sehgal AR Shah VO Smith MW Taylor KD Winkler CA Zager PG Freedman BI;Family Investigation of Nephropathy Diabetes Research Group 《Diabetes》2007,56(6):1577-1585
The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for diabetic nephropathy. We report the findings from the first-phase genetic analyses in 1,227 participants from 378 pedigrees of European-American, African-American, Mexican-American, and American Indian descent recruited from eight centers. Model-free linkage analyses, using a dichotomous definition for diabetic nephropathy in 397 sibling pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performed using the Haseman-Elston linkage test on 404 microsatellite markers. The strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10p15.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2q14.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 10p, and 18q from prior reports, making it important that genes underlying these peaks be evaluated for their contribution to nephropathy susceptibility. Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes. 相似文献