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991.
992.
Baseline Sarcopenia is Associated with Lack of Response to Therapy,Liver Decompensation and High Mortality in Hepatocellular Carcinoma Patients
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![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Hanaa BadranMaha Mohammad ElsabaawyAmr RagabRasha Abdelhafiz AlyAyman AlsebaeyAliaa Sabry 《Asian Pacific journal of cancer prevention》2020,21(11):3285-3290
Objective: hepatocellular carcinoma (HCC) is a dreadful complication of liver cirrhosis. Aim was to study the effect of sarcopenia on the survival in patients with HCC. Methods: we included 262 patients and were followed up for 12 months. Sarcopenia was calculated by skeletal muscle index (SMI). Sarcopenia was defined by SMI ≤39 cm2/m2 for women and ≤50 cm2/m2 for men. Results: patients with sarcopenia (n= 113, 43.1%) were older, mainly males, Child-Pugh class B and smokers. Patients with sarcopenia had lower survival than those without (10.09 vs. 11.72 months). Survival was also lower in Barcelona clinic liver cancer stage C than B and A (9.02 vs. 11.21 vs. 11.89 months). Age and sarcopenia were hazardous of mortality (p <0.05). There was statistically significant difference of serial SMI in patients without baseline sarcopenia unlike patients with baseline sarcopenia. On follow up patients with sarcopenia had higher incidence of ascites (45% vs. 20.4%), spontaneous bacterial peritonitis (21.7% vs. 11.6%), hepatic encephalopathy (28% vs. 11.5%) and bleeding (22.9% vs. 12.7%). Totally patients with sarcopenia had higher incidence of progressive HCC (39% vs. 25.5%). Conclusion: Sarcopenia is associated with lack of response to therapy, liver decompensation and higher mortality in hepatocellular carcinoma patients. 相似文献
993.
Huang G Pashmforoush M Chung B Saxon LA 《Journal of cardiovascular translational research》2011,4(1):61-65
Recent advances in stem cell biology and tissue engineering have put forth new therapeutic paradigms for treatment of myocardial
disease. The aim of stem cell therapy for myocardial regeneration has been directed to induce angiogenesis for ischemic heart
disease and/or introduction of new cardiomyocytes to improve the mechanical function of the failing heart. Encouraged by positive
preliminary results in mouse models of myocardial infarction, clinical trials have utilized autologous skeletal myoblasts
and bone-marrow-derived stem cells to treat patients in various clinical settings including acute myocardial injury, chronic
angina, and heart failure [1–3]. These studies have collectively shown, at best, modest improvement in cardiac function. This may be due to the fact that
there is little evidence to support actual formation and/or integration of transplanted cells into the recipient myocardium.
More recent and emerging data supports the finding that electrical stimulation may be an effective catalyst for sustained
functional organization, integration, and maturation of transplanted cell populations into the host myocardium. A therapeutic
model that utilizes electrical stimulation and/or achieves cardiac resynchronization in conjunction with stem cell transplantation
may be an effective means to achieve successful myocardial regenerative therapy. 相似文献
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995.
Alcohol‐attributed disease burden in four Nordic countries: a comparison using the Global Burden of Disease,Injuries and Risk Factors 2013 study
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![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Emilie E. Agardh Anna‐Karin Danielsson Mats Ramstedt Astrid Ledgaard Holm Finn Diderichsen Knud Juel Stein Emil Vollset Ann Kristin Knudsen Jonas Minet Kinge Richard White Vegard Skirbekk Pia Mäkelä Mohammad Hossein Forouzanfar Matthew M. Coates Daniel C. Casey Mohesen Naghavi Peter Allebeck 《Addiction (Abingdon, England)》2016,111(10):1806-1813
996.
Hanan E. Shamseldin Ranad Shaheen Nour Ewida Dalal K. Bubshait Hisham Alkuraya Elham Almardawi Ali Howaidi Yasser Sabr Ebtesam M. Abdalla Abdullah Y. Alfaifi Jameel Mohammed Alghamdi Afaf Alsagheir Ahmed Alfares Heba Morsy Maged H. Hussein Mohammad A. Al-Muhaizea Mohammad Shagrani Essam Al Sabban Fowzan S. Alkuraya 《Genetics in medicine》2022,24(4):966
997.
Faleh Tamimi Jesus Torres Khadijeh Al-Abedalla Enrique Lopez-Cabarcos Mohammad H. Alkhraisat David C. Bassett Uwe Gbureck Jake E. Barralet 《Biomaterials》2014
Onlay grafts made of monolithic microporous monetite bioresorbable bioceramics have the capacity to conduct bone augmentation. However, there is heterogeneity in the graft behaviour in vivo that seems to correlate with the host anatomy. In this study, we sought to investigate the metabolic activity of the regenerated bone in monolithic monetite onlays by using positron emission tomography–computed tomography (PET-CT) in rats. This information was used to optimize the design of monetite onlays with different macroporous architecture that were then fabricated using a 3D-printing technique. In vivo, bone augmentation was attempted with these customized onlays in rabbits. PET-CT findings demonstrated that bone metabolism in the calvarial bone showed higher activity in the inferior and lateral areas of the onlays. Histological observations revealed higher bone volume (up to 47%), less heterogeneity and more implant osseointegration (up to 38%) in the augmented bone with the customized monetite onlays. Our results demonstrated for the first time that it is possible to achieve osseointegration of dental implants in bone augmented with 3D-printed synthetic onlays. It was also observed that designing the macropore geometry according to the bone metabolic activity was a key parameter in increasing the volume of bone augmented within monetite onlays. 相似文献
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