全文获取类型
收费全文 | 3197篇 |
免费 | 153篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 78篇 |
儿科学 | 30篇 |
妇产科学 | 28篇 |
基础医学 | 415篇 |
口腔科学 | 47篇 |
临床医学 | 185篇 |
内科学 | 898篇 |
皮肤病学 | 39篇 |
神经病学 | 223篇 |
特种医学 | 84篇 |
外科学 | 517篇 |
综合类 | 10篇 |
预防医学 | 118篇 |
眼科学 | 27篇 |
药学 | 156篇 |
中国医学 | 2篇 |
肿瘤学 | 510篇 |
出版年
2023年 | 18篇 |
2022年 | 36篇 |
2021年 | 67篇 |
2020年 | 42篇 |
2019年 | 27篇 |
2018年 | 47篇 |
2017年 | 40篇 |
2016年 | 66篇 |
2015年 | 49篇 |
2014年 | 51篇 |
2013年 | 71篇 |
2012年 | 140篇 |
2011年 | 154篇 |
2010年 | 84篇 |
2009年 | 69篇 |
2008年 | 146篇 |
2007年 | 142篇 |
2006年 | 163篇 |
2005年 | 157篇 |
2004年 | 149篇 |
2003年 | 126篇 |
2002年 | 87篇 |
2001年 | 116篇 |
2000年 | 101篇 |
1999年 | 89篇 |
1998年 | 49篇 |
1997年 | 26篇 |
1996年 | 24篇 |
1995年 | 18篇 |
1993年 | 17篇 |
1992年 | 67篇 |
1991年 | 70篇 |
1990年 | 68篇 |
1989年 | 65篇 |
1988年 | 70篇 |
1987年 | 68篇 |
1986年 | 71篇 |
1985年 | 83篇 |
1984年 | 48篇 |
1983年 | 38篇 |
1982年 | 19篇 |
1979年 | 24篇 |
1978年 | 19篇 |
1977年 | 22篇 |
1975年 | 19篇 |
1973年 | 19篇 |
1971年 | 17篇 |
1969年 | 24篇 |
1968年 | 34篇 |
1967年 | 20篇 |
排序方式: 共有3367条查询结果,搜索用时 31 毫秒
21.
Hemagglutination is a novel biological function of lipopolysaccharide (LPS), as seen with the Vibrio cholerae O139 LPS.
下载免费PDF全文
![点击此处可从《Clinical and Vaccine Immunology : CVI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
It has been generally thought that the polysaccharide moiety of lipopolysaccharide (LPS) maintains only serological specificity, while the lipid A portion determines various biological functions. However, we found that hemagglutination was a common function of the polysaccharide moiety of LPSs from important human enteropathogenic bacteria. Of the LPSs examined, Vibrio cholerae O139 LPS showed the highest hemagglutinating activity. Glycoproteins, such as mucin and fetuin, showed efficient inhibition of the hemagglutinating ability. Since cell-mediated hemagglutination is known to be correlated with bacterial adherence, hemagglutination induced by the polysaccharide moiety is interpreted to indicate that cell-surface LPS is a potential adhesin. 相似文献
22.
C-reactive protein levels in the serum of asthmatic patients. 总被引:1,自引:0,他引:1
Miyoshi Fujita Shigeharu Ueki Wataru Ito Takahito Chiba Masahide Takeda Norihiro Saito Hiroyuki Kayaba Junichi Chihara 《Annals of allergy, asthma & immunology》2007,99(1):48-53
BACKGROUND: Asthma is a chronic airway inflammatory disease caused by immune cells such as T lymphocytes and eosinophils. Recently, highly sensitive C-reactive protein (hs-CRP) assays have become available for detecting small changes in CRP levels within the reference range, allowing for the evaluation of clinical inflammation. OBJECTIVE: To investigate the relationship between hs-CRP levels and bronchial asthma. METHODS: We collected blood samples from 109 patients with bronchial asthma, with or without attacks, and measured serum eosinophil cationic protein levels, pulmonary function, and serum CRP levels using an hs-CRP assay. RESULTS: Mean serum hs-CRP levels were significantly higher in patients without attacks (0.473 mg/L) and with attacks (0.908 mg/L) (P < .001 for both) than in controls (0.262 mg/L). Serum hs-CRP levels were inversely correlated with forced expiratory volume in 1 second/forced vital capacity in asthmatic patients (r = -0.4915; P < .01). CONCLUSION: Serum hs-CRP levels may be related to the state of asthma exacerbation and allergic inflammation. 相似文献
23.
Kazuhiko Orikasa Shin-ichi Fukushige Senji Hoshi Seiichi Orikasa Keiichi Kondo Yasuhide Miyoshi Yoshinobu Kubota A. Horii 《Journal of human genetics》1998,43(4):228-230
Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular
mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported
in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers.
These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.
Received: February 6, 1998 / Accepted: July, 3, 1998 相似文献
24.
Summary Ultrastructures of Japanese monkey(Macaca fuscata)-derived type C virus particles in a monkey lymphoid cell line, expressing adult T-cell leukemia (ATL)-associated antigens, are indistinguishable from those of human ATL-associated virus in human and monkey cell lines.With 6 Figures 相似文献
25.
26.
Expression and possible role of ets-1 in hepatocellular carcinoma 总被引:11,自引:0,他引:11
27.
28.
29.
Yasuyuki Sumikawa Yuriko Ueki Akira Miyoshi Lei Cheng Min Yin Hai-Bo Shi Masuko Daitoku Sumikawa Takeshi Kono Toshiyuki Aoki Ichiro Katayama 《Arerugī》2007,56(10):1270-1275
BACKGROUND: The comparative studies of the prevalence of atopic dermatitis and skin barrier functions in Japanese and Chinese were performed. METHODS: Clinical investigations were performed in 68 elementary school students in Lhasa, Tibet Autonomous Region and 67 students in Yixing, Jiangsu Province in China, and 99 students in Nishinomiya, Hyogo in Japan. Transepidermal water loss (TEWL) and capacitance were measured. Questionary survey about bathing frequency was also performed for students in Lhasa, Yixing and Osaka. RESULT: The prevalence rate of atopic dermatitis was 0% in Lhasa, 2.63% in Yixing, 4.26% in Nishinomiya. TEWL of students in Nishinomiya was higher than that in Yixing and Lhasa. Capacitance of students in Lhasa was lower than that in Nishinomiya and Yixing. The frequency of taking a bath in Lhasa was about 2.2 times per month and fewer than that in Nishinomiya and Yixing. CONCLUSION: There was tendency that the prevalence of atopic dermatitis increased according to increase of TEWL. It was thought that more investigations are necessary whether the development of habitat and environment influence the prevalence of atopic dermatitis and skin barrier function. 相似文献
30.
Nobuyuki Kuroda Yoshinori Nishikitani Kazuo Matsuura Mitsuji Miyoshi 《Macromolecular chemistry and physics.》1987,188(8):1897-1907
Ethylene/1-butene copolymers prepared with a heterogeneous titanium-based catalyst were separated into five fractions by successive solvent extraction, and the triad distributions of each fraction were determined by 13C NMR measurements. Conditional probabilities (PEE, PEB, PBE, PBB), reactivity ratios (r1, r2), and persistence ratio (p) of each fraction were calculated from the triad distributions observed. The analysis of these values suggests that the heterogeneous Ziegler catalyst has multiple active sites, and the copolymer has nearly a Bernoullian sequence distribution. 相似文献