Psychosocial and environmental factors associated with physical activity among city dwellers in regional Queensland

BACKGROUND: Research has recently adopted the use of social-ecological models in the study of physical activity. Few studies, however, have addressed the influence of the environment on activity using Geographic Information System (GIS)-derived measures of environmental attributes and self-report ratings of other environmental attributes. Even fewer have examined walking behaviors. METHODS: Self-report measures of physical activity, social support, self-efficacy, and perceived neighborhood environment were obtained by means of a Computer-Assisted-Telephone-Interview (CATI) survey of 1,281 residents of Rockhampton, Queensland. Over 94% (1,215) of respondents' residential locations were successfully geocoded into the existing city council GIS database. The self-report data, along with GIS-derived measures, were used to determine the relationships among selected variables of the neighborhood environment for each geocoded location. RESULTS: GIS-derived measures of street connectivity and proximity to parkland, the number of active people in a 1-km radius, and self-reported perceptions of neighborhood cleanliness showed associations with the likelihood of achieving sufficient levels of physical activity when adjusting for selected psychosocial variables. GIS-derived Euclidian distance to footpath networks, number of dogs in 0.8-km radius, network distance to newsagents, and perceptions of footpath condition were significantly associated with the likelihood of participating in any recreational walking. CONCLUSION: Environmental characteristics were found to have differential influences on the two selected measures of physical activity. Aesthetics and safety appear to be important influences of physical activity, whereas proximal footpaths showed increased likelihood of participation in recreational walking. It is proposed that the strength of association between the environmental and physical activity may be improved if future research utilizes a Geographic Information System approach to the study of restricted geographical areas.     

Reversible renal failure and myositis caused by phenytoin hypersensitivity.

A 38-year old woman receiving phenytoin (diphenylhydantoin) noticed maculopapular erythema as the first manifestation of a syndrome that included acute renal failure and myositis in addition to fever, lymphadenopathy, exfoliative dermatitis, and hepatitis. Prednisolone sodium phosphate therapy resulted in resolution of this hypersensitivity reaction, and she recovered from renal insufficiency. The occurrence of renal failure and myositis in the spectrum of phenytoin hypersensitivity reactions is discussed, and the importance of a morbilliform rash in a patient receiving phenytoin is emphasized.     

Morbid obesity treated by gastroplasty: radionuclide gastric emptying studies

Mechanisms by which gastroplasty for morbid obesity causes weight loss are poorly understood. We studied the role of altered gastric emptying in 50 patients before surgery, 1-4 weeks after surgery, and 2-24 months after surgery using technetium-99m pentetate in water for liquid meals and a Tc-99m styrene divinylbenzene copolymer resin in oatmeal for semisolid meals. We determined the emptying half-times of the stomach before and after surgery in the proximal and distal compartments. The proximal compartment emptied promptly in the early and late postoperative periods. The distal compartment emptied liquids at rates similar to those before surgery, while the late postoperative emptying of semisolids was significantly faster. The stoma connecting the two compartments thus permits rapid transit of liquids and semisolids without delay of distal compartment emptying. No correlation was seen between the emptying half-times or changes thereof and eventual weight loss. Delayed gastric emptying is therefore not the mechanism for satiety and weight loss after gastroplasty has been performed.     

Chemotherapy-induced alopecia: psychosocial impact and therapeutic approaches

Despite advances in the treatment of many side effects associated with chemotherapy, alopecia remains an issue that is difficult to resolve. Chemotherapy-induced alopecia (CIA) is a condition that can have profound psychosocial and quality-of-life consequences, resulting in anxiety, depression, a negative body image, lowered self-esteem, and a reduced sense of well-being. Patients who fear CIA may sometimes select regimens with less favorable outcomes or may refuse treatment. When supporting patients with CIA, health care providers should use an individualized approach with a focus placed on the actual moment of hair loss. Education, support groups, and self-care strategies are important components of any management approach. No treatment modality for preventing CIA has been clearly shown to be effective. Recent evidence suggests that new scalp hypothermic regimens may be safe and effective. There remains a critical need for effective new approaches to this problem.     

Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia

Background

Farnesyl protein transferase inhibitors (FTIs) were originally developed to inhibit oncogenic ras, however it is now clear that there are several other potential targets for this drug class. The FTI tipifarnib (ZARNESTRA?, R115777) has recently demonstrated clinical responses in adults with refractory and relapsed acute leukemias. This study was conducted to identify genetic markers and pathways that are regulated by tipifarnib in acute myeloid leukemia (AML).

Methods

Tipifarnib-mediated gene expression changes in 3 AML cell lines and bone marrow samples from two patients with AML were analyzed on a cDNA microarray containing approximately 7000 human genes. Pathways associated with these expression changes were identified using the Ingenuity Pathway Analysis tool.

Results

The expression analysis identified a common set of genes that were regulated by tipifarnib in three leukemic cell lines and in leukemic blast cells isolated from two patients who had been treated with tipifarnib. Association of modulated genes with biological functional groups identified several pathways affected by tipifarnib including cell signaling, cytoskeletal organization, immunity, and apoptosis. Gene expression changes were verified in a subset of genes using real time RT-PCR. Additionally, regulation of apoptotic genes was found to correlate with increased Annexin V staining in the THP-1 cell line but not in the HL-60 cell line.

Conclusions

The genetic networks derived from these studies illuminate some of the biological pathways affected by FTI treatment while providing a proof of principle for identifying candidate genes that might be used as surrogate biomarkers of drug activity.