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11.
Rebecca E. Graff Andreas Pettersson Rosina T. Lis Natalie DuPre Kristina M. Jordahl Elizabeth Nuttall Jennifer R. Rider Michelangelo Fiorentino Howard D. Sesso Stacey A. Kenfield Massimo Loda Edward L. Giovannucci Bernard Rosner Paul L. Nguyen Christopher J. Sweeney Lorelei A. Mucci 《The Prostate》2015,75(9):897-906
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Maestri Michelangelo Romigi Andrea Schirru Alessandro Fabbrini Monica Gori Sara Bonuccelli Ubaldo Bonanni Enrica 《Sleep & breathing》2020,24(2):413-424
Sleep and Breathing - Excessive daytime sleepiness (EDS) and fatigue are some of the most frequent symptoms in neurological diseases and could impact on quality of life by increasing the risk of... 相似文献
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Noto D Cefalù AB Barbagallo CM Falletta A Ganci A Sapienza M Cavera G Nardi I Pagano M Notarbartolo A Averna MR 《Acta diabetologica》2012,49(2):145-151
A novel algorithm to predict incident type 2 diabetes mellitus (iT2DM) is presented considering data from a 20-year prospective study in a Southern Italy population. Eight hundred and fifty-eight out of 1,351 subjects (24?C85?years range of age) were selected. Incident type 2 diabetes was diagnosed in 103 patients in a 20-year follow-up. The Finnish Diabetes Risk Score (FINDRISC) and the Framingham Offspring Study simple clinical model (FOS) have been used as reference algorithms. Two custom algorithms have been created using Cox parametric hazard models followed by PROBIT analyses: the first one (VHSRISK) includes all the study subjects and the second one (VHS95RISK) evaluates separately subjects with baseline fasting blood glucose (FBG) above/below 5.2?mmol/L (95?mg/dL). The 44 iT2DM cases below 5.2?mmol/L of baseline FBG were predicted by high LDL cholesterol, metabolic syndrome (ATPIII criteria), BMI?>?30?kg/m2, and high factor VII activity. The 59 cases above the FBG threshold were predicted by FBG classes, hypertension, and age. ROC areas for iT2DM prediction were: FINDRISC?=?0.759, FOS?=?0.762, VHSRISK?=?0.789, and VHS95RISK?=?0.803. In a Mediterranean population, the use of a custom generated algorithm evaluating separately low/high FBG subjects improves the prediction of iT2DM in subjects classified at lower risk by common estimation algorithms. 相似文献
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Montano V. Orsucci D. Carelli V. La Morgia C. Valentino M. L. Lamperti C. Marchet S. Musumeci O. Toscano A. Primiano G. Santorelli F. M. Ticci C. Filosto M. Rubegni A. Mongini T. Tonin P. Servidei S. Ceravolo R. Siciliano G. Mancuso Michelangelo 《Journal of neurology》2022,269(3):1413-1421
Journal of Neurology - Both prevalence and clinical features of the various movement disorders in adults with primary mitochondrial diseases are unknown. Based on the database of the... 相似文献
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Michelangelo Mancuso Daniele Orsucci Corrado Angelini Enrico Bertini Michela Catteruccia Elena Pegoraro Valerio Carelli Maria L. Valentino Giacomo P. Comi Carlo Minetti Claudio Bruno Maurizio Moggio Elena Caldarazzo Ienco Tiziana Mongini Liliana Vercelli Guido Primiano Serenella Servidei Paola Tonin Mauro Scarpelli Antonio Toscano Olimpia Musumeci Isabella Moroni Graziella Uziel Filippo M. Santorelli Claudia Nesti Massimiliano Filosto Costanza Lamperti Massimo Zeviani Gabriele Siciliano 《Movement disorders》2014,29(6):722-728
Myoclonus is a possible manifestation of mitochondrial disorders, and its presence is considered, in association with epilepsy and the ragged red fibers, pivotal for the syndromic diagnosis of MERRF (myoclonic epilepsy with ragged red fibers). However, its prevalence in mitochondrial diseases is not known. The aims of this study are the evaluation of the prevalence of myoclonus in a big cohort of mitochondrial patients and the clinical characterization of these subjects. Based on the database of the “Nation‐wide Italian Collaborative Network of Mitochondrial Diseases,” we reviewed the clinical and molecular data of mitochondrial patients with myoclonus among their clinical features. Myoclonus is a rather uncommon clinical feature of mitochondrial diseases (3.6% of 1,086 patients registered in our database). It is not strictly linked to a specific genotype or phenotype, and only 1 of 3 patients with MERRF harbors the 8344A>G mutation (frequently labeled as “the MERRF mutation”). Finally, myoclonus is not inextricably linked to epilepsy in MERRF patients, but more to cerebellar ataxia. In a myoclonic patient, evidences of mitochondrial dysfunction must be investigated, even though myoclonus is not a common sign of mitochondriopathy. Clinical, histological, and biochemical data may predict the finding of a mitochondrial or nuclear DNA mutation. Finally, this study reinforces the notion that myoclonus is not inextricably linked to epilepsy in MERRF patients, and therefore the term “myoclonic epilepsy” seems inadequate and potentially misleading. © 2014 International Parkinson and Movement Disorder Society 相似文献
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Porfidia Angelo Agostini Fabiana Giarretta Igor Tonello Diego Pastori Daniele Pignatelli Pasquale Santoliquido Angelo Sartori Michelangelo Lessiani Gianfranco Visonà Adriana Donadini Marco P. Pola Roberto 《Journal of thrombosis and thrombolysis》2020,50(2):355-360
Journal of Thrombosis and Thrombolysis - Upper-extremity deep vein thrombosis (UEDVT) accounts for about 5–10% of all cases of deep vein thrombosis (DVT). It is often associated with cancer... 相似文献