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Type II focal cortical dysplasia: Ex vivo 7T magnetic resonance imaging abnormalities and histopathological comparisons
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Ileana Zucca PhD Gloria Milesi PhD Valentina Medici PhD Laura Tassi MD Giuseppe Didato MD Francesco Cardinale MD Giovanni Tringali MD Nadia Colombo MD Manuela Bramerio MD Ludovico D'Incerti MD Elena Freri MD Michela Morbin MD Valeria Fugnanesi MSc Matteo Figini PhD Roberto Spreafico MD PhD Rita Garbelli PhD 《Annals of neurology》2016,79(1):42-58
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Affective response to observation of intra-species and inter-species interactions was considered in the present research. The brain activity (optical imaging: functional Near-Infrared Spectroscopy, fNIRS; and event-related potentials, ERPs, N200) was monitored when subjects observed interactive situations (human-human, HH; human-animal, HA) with a positive (cooperative), negative (uncooperative) or neutral (no emotional) content. In addition, cortical lateralization (more left or right prefrontal activity) and personality component (Behavioral Activation System, BAS; Behavioral Inhibition System, BIS) effects were explored. Both ERP and fNIRS showed significant brain activity increasing in response to positive and negative compared with neutral interactions for HH and HA. However, some differences were found between HH (more “negative valence” effect) and HA (more “positive valence” effect). Finally BAS and BIS were related respectively to more left (positive conditions) or right (negative conditions) hemispheric activity. These results supported the significance of affective behavior differentiating the species-specific and species-aspecific relationships. 相似文献
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Erica Visintin Michela Tinelli Panos Kanavos 《Health policy (Amsterdam, Netherlands)》2019,123(2):118-129
This study systematically compares HTA recommendations on a number of disease–modifying therapies for patients with Relapsing-Remitting Multiple Sclerosis. We analysed publicly available HTA reports for nine medicine-indication pairs across seven OECD countries using a methodological framework enabling systematic analysis of HTA recommendations. The analysis was conducted based on a number of value dimensions, including clinical and economic variables, as well as several other dimensions of value beyond cost-effectiveness. The material was qualitatively and quantitatively coded following the different stages of HTA decision-making process. Fifty-seven medicine-indication pairs were assessed across the study countries. Of those, eight medicine indication-pairs reported diverging HTA recommendations. Although HTA recommendations were based on the same evidence submitted in most cases, significant variations were identified in interpretation and acceptance of evidence resulting in different uncertainties raised and different ways of addressing them. Uncertainties arose both in terms of the clinical and the economic evidence, including the design of key trials or the data quality in economic models. Beyond costs and effects, additional dimensions of value had an impact in the direction of recommendations, however with different magnitude across countries. We show that there is heterogeneity across countries in HTA for evaluating DMTs for RRMS with a lack of standardised methods in evaluating clinical and economic evidence and the use of social value judgments to inform decision-making. 相似文献
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