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991.
O'Donnell M 《British medical journal (Clinical research ed.)》1984,288(6419):804
The parents of a deceased accident victim who had carried a donor card have recently founded the British Organ Donor Society to serve as a support and self help group for donor families, to act as a voice on their behalf, and to promote the carrying of donor cards. O'Donnell describes the initiative taken by the Evans family, calls for a public campaign to increase the use of donor cards, and encourages physicians to adopt a more positive attitude toward approaching the families of potential donors for permission to remove organs. 相似文献
992.
David J. Stewart Brien Benoit Michael T. Richard Herman Hugenholtz Jean Dennery Neville Russell Eric Peterson Zvonimir Grahovac Garry Belanger Jean A. Maroun Vincent Young 《Journal of neuro-oncology》1984,2(1):53-58
Summary Twenty-six adult patients with astrocytomas were treated with BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) 180–240 mg/m2 1.V. every 6–9 weeks, with metronidazole 1.5 g/m2 p. o. 12 h and 1 h before BCNU and again 6 h and 24 h after BCNU. Of twenty-two evaluable patients, 9 (41%) responded with evidence of reduced tumor size on CT scan, 3 (14%) stabilized and 10 (45%) failed. Patients with no prior chemotherapy or radiotherapy, good performance. status, low grade tumors, and age 50 years had the highest response rates, although differences were not statistically significant. Median survival and duration of response have not been reached with a median follow-up time of ten months. Hematological toxicity was dose-limiting and was probably not augmented by the metronidazole. There was one death from infection that was possibly drug-related. Gastrointestinal toxicity was substantial, and was probably increased by the metronidazole.While the combination of BCNU and metronidazole were tolerable, the response rate seen was no higher than that noted for BCNU alone, and further studies using this dose-schedule are not recommended in astrocytomas.Presented at the 13th International Congress of Chemotherapy, Vienna Austria, August 1983. 相似文献
993.
David J Stewart MD FRCP Michael T Richard Herman Hugenholtz Jean Dennery Dev Nundy Judith Prior Vital Montpetit Harry S Hopkins 《Journal of neuro-oncology》1984,2(4):315-324
Thirty-four consenting patients received VM-26 50–100 mg/m2 I.V. before surgical resection of intracerebral tumor, and drug was measured using a high pressure liquid chromatographic technique. Sufficient tumor for analysis was obtained from 29 patients. Brain metastases (13 patients) had higher concentrations of V M-26 than did gliomas (13 patients). Concentrations were comparable in brain metastases and meningiomas (3 patients). Prolonged (24 h) infusion of V M-26 did not appear to result in higher tumor drug concentrations in 5 patients than did rapid (1 h) infusion in 24 patients. Pretreatment with Amphotericin-B 10 mg/m2 12 h and 1 h before VM-26 did not appear to have any effect on VM-26 uptake into 4 intracerebral tumors, although data were limited, and VM-26 concentrations were very high in 1 metastasis. Pretreatment with oral glycerol 500 mg/kg 18 h, 12 h, 6 h, and immediately before I.V. VM-26 may have resulted in increased penetration of VM-26 into 9 tumors, although confirmation is required. Amphotericin-B, glycerol, and operative conditions did not appear to alter VM-26 plasma pharmacokinetics.VM-26
4-demethylepipodophyllotoxin 9-(4-6-O-thenylidene-B-D-glucopyranoside)
- VP-16
4-demethylepipodophyllotoxin 9-(4-6-O-ethylidene-B-D-glucopyranoside)
Presented in Part at the 74th Annual Meeting of the American Association for Cancer Research, San Diego, California, May 25–28, 183(1). 相似文献
994.
Egede Leonard E. Walker Rebekah J. Dawson Aprill Z. Zosel Amy Bhandari Sanjay Nagavally Sneha Martin Ian Frank Michael 《Quality of life research》2022,31(8):2387-2396
Quality of Life Research - This study aimed to investigate changes over time in quality of life, perceived stress, and serious psychological distress for individuals diagnosed with COVID-19 in an... 相似文献
995.
Gass Julie C. Funderburk Jennifer S. Wade Michael Acker John D. Maisto Stephen A. 《Zeitschrift fur Gesundheitswissenschaften》2022,30(3):771-780
Journal of Public Health - To determine whether statistically distinct classes of smokers exist according to mental health (MH) diagnoses within primary care and to evaluate whether class... 相似文献
996.
Collie Alex Sheehan Luke Di Donato Michael 《Journal of occupational rehabilitation》2022,32(2):203-214
Journal of Occupational Rehabilitation - Purpose: To compare the frequency of General Practitioner (GP) services and the time between first and last GP services (service duration) provided to... 相似文献
997.
Magdalena Hoffmann Christine Maria Schwarz Stefan Fürst Christina Starchl Elisabeth Lobmeyr Gerald Sendlhofer Marie-Madlen Jeitziner 《Nutrients》2021,13(1)
Critically ill patients in the intensive care unit (ICU) have a high risk of developing malnutrition, and this is associated with poorer clinical outcomes. In clinical practice, nutrition, including enteral nutrition (EN), is often not prioritized. Resulting from this, risks and safety issues for patients and healthcare professionals can emerge. The aim of this literature review, inspired by the Rapid Review Guidebook by Dobbins, 2017, was to identify risks and safety issues for patient safety in the management of EN in critically ill patients in the ICU. Three databases were used to identify studies between 2009 and 2020. We assessed 3495 studies for eligibility and included 62 in our narrative synthesis. Several risks and problems were identified: No use of clinical assessment or screening nutrition assessment, inadequate tube management, missing energy target, missing a nutritionist, bad hygiene and handling, wrong time management and speed, nutritional interruptions, wrong body position, gastrointestinal complication and infections, missing or not using guidelines, understaffing, and lack of education. Raising awareness of these risks is a central aspect in patient safety in ICU. Clinical experts can use a checklist with 12 identified top risks and the recommendations drawn up to carry out their own risk analysis in clinical practice. 相似文献
998.
Alcohol and physical inactivity are risk factors for a variety of cancer types. However, alcohol use often co-occurs with physical activity (PA), which could mitigate the cancer-prevention benefits of PA. Alcohol is integrated into the culture of one of the most popular physical activities for adults in the United States (U.S.), golf. This study examined how alcohol use was associated with total PA, golf-specific PA, and motives for golfing in a national sample of golfers in the U.S. Adult golfers (n = 338; 51% male, 81% White, 46 ± 14.4 years) self-reported alcohol use, golfing behavior and motives, and PA. Most (84%) golfers consumed alcohol, averaging 7.91 servings/week. Golf participation, including days/week, holes/week, and practice hours/week, was not associated with alcohol use. Golfers with stronger social motives were 60% more likely to consume alcohol. Weekly walking (incident risk ratio (IRR) = 7.30), moderate-to-vigorous PA (MVPA; IRR = 5.04), and total PA (IRR = 4.14) were associated with more alcohol servings/week. Golfers’ alcohol use may be higher than the general adult population in the U.S. and contributes 775 extra kilocalories/week, a surplus that may offset PA-related energy expenditure and cancer-protective effects. Alcohol use interventions targeting golfers may facilitate weight loss and reduce cancer risk, especially for golfers motivated by social status. 相似文献
999.
1000.
DeMarco Mario P. Shafqat Maha Horst Michael A. Srinivasan Sukanya Frayne Daniel J. Schlar Lisa Barr Wendy Brooks 《Maternal and child health journal》2021,25(2):207-213
Maternal and Child Health Journal - Each year, 3% of infants in the Unites States (US) are born with congenital anomalies, including 3000 with neural tube defects. Multivitamins (MVIs) including... 相似文献