Disorders of perfusion of the anterior segment of the eye

Background: We have investigated the vascular perfusion of a wide variety of conditions of the anterior segment using fluorescein angiography.
Methods: The conditions were classified and findings reported according to the system set out below. Patients underwent full ocular examination. Fluorescein angiography of the anterior segment was carried out when indicated to investigate iris atrophy and neovascularisation. Specular microscopy of the corneal endothelium was used to detect changes in this tissue.
Results: The hypoperfusion was variable in degree and accompanied by varying degrees of iris hypoplasia and atrophy with neovascularisation. The degree of neovascularisation depended upon its rapidity of development, the pre-existing state of vascular perfusion and the underlying pathological condition.
Conclusions: Hypoperfusion with resultant ischaemia and neovascularisation is common in conditions of the anterior segment. An understanding of the changes is valuable in treating many conditions affecting the anterior segment. The changes observed may also occur elsewhere in the physical system and may be a significant part of the ageing process, either as scattered, disparate processes or as part of a general disease process.     

Prolactinoma in the male

In a retrospective study the medical records of 13 male patients with macroprolactinomas were evaluated concerning anamnestic data, clinical, endocrinological and localisation-diagnostic findings as well as therapeutic measures. The main symptoms were disturbances of vision and impaired potency and impaired libido, respectively. The ophthalmological complaints nearly exclusively caused the patients to see the doctor. Clinically the signs of hypogonadism were found. The diagnosis was ascertained by increased serum prolactin levels, ophthalmological findings, X-ray of the sella, cranial computed tomography as well as angiography of the carotid. The operative treatment did not show any normalization of the serum prolactin levels. The rate of recidivations after exclusive operative treatment was high. An additional medicamentous therapy with dopamine agonists is nearly always necessary after operation. Whether or not bromocriptine shall be used as primary therapy, must be decided on in the individual case.     

Postoperative radiation therapy in the management of lung cancer

Postoperative radiation therapy for lung cancer is still controversial. In a 9-year period, 69 patients with non-oat-cell carcinoma of the lung (16% stage I, 26% stage II, and 58% stage III) received such therapy. The radiation dose was less than 5,000 cGy in 42 patients, 5,000-5,900 cGy in 16, and 6,000 cGy or more in 11; follow-up ranged from 24 to 64 months. Actuarial survival at 2 and 4 years was 50% and 16%, respectively, for squamous cell carcinoma, and 40% and 26% for adenocarcinoma. The 5-year survival for stages I, II, and III cancer was 29%, 17%, and 19%, respectively. Histologic findings and type of surgery did not affect survival, but the radiation dose apparently did. The 3-year survival for patients who received less than 6,000 cGy was 35%, compared with 73% for patients who received higher doses. In eight patients, treatment failed within the irradiated volume: all had received doses of less than 6,000 cGy, and the volume in three was judged to be inadequate.     

尖锐湿疣患者人乳头瘤病毒的基因分型

目的 探索尖锐湿疣患者人乳头瘤病毒的基因分型。方法 PCR方法检测HPV6／11型、HPV16／18型DNA。结果 检测尖锐湿疣患者100例，对其中35例进行组织活检，阳性检出率为91．4％(32／35)，阳性检出中，HPV6／11型26例(81．2％)，HPV16／18型3例(9．4％)，HPV6／11 HPV16／18型3例(9．4％)；对其中65例进行宫颈抹片检测，阳性检出率为92．3％(60／65)，阳性检出中，HPV6／11型41例(68．3％)，HPV16／18型12例(20．0％)，HPV6／11 HPV16／18型7例(11．7％)。结论 尖锐湿疣患者人乳头瘤病毒感染以HPV6／11型为主，HPV16／18型在宫颈处感染率高于其它处组织。     

GGTⅡ,ALPⅠ,AAT诊断原发性肝癌探讨

对１０１例原发性肝癌（ＰＨＣ）同步检测几项标记，其阳性率为ＡＦＰ７６．２％，ＧＧＴⅡ８５．１％，ＡＬＰⅠ２４．８％，ＡＡＴ７５．１％。与肝硬化、慢性肝炎、肝良性占位性病变、肝外肿瘤、正常人等组比较，差异有显著性。假阳性率以肝硬化用组高，分别为ＡＦＰ１５．０％，ＧＧＴⅡ１０．０％，ＡＬＰⅠ３．３％，ＡＡＴ２６．７％。在ＡＦＰ＜５０ｎｇ／ｍｌ２４例中，ＧＧＴⅡ阳性率为７０．８％，ＡＬＰⅠ为１６．７％，ＡＡＴ为６６．７％。本文结果显示、ＧＧＴⅡ诊断ＰＨＣ敏感性、特异性均佳，优于ＡＦＰ、ＡＬＰⅠＩ及ＡＡＴ。ＧＧＴⅡ与ＡＦＰ互补诊断可提高阳性率。     

利用T7和PR双启动子的新型表达载体的构建及其应用

构建具有λＰＲ与Ｔ７双启动动子的新型原核表达载体ｐＤＯＧ，以便使用同一载体研究不同诱导条件下，重组蛋白在大肠杆菌中表达，降解以及折叠的情况，从而选择最佳的诱导条件。方法采用ｐＢＶ２２０与ＰＥＴ－３表达载体作为原始材料，将ＰＥＴ－３上包括Ｔ７启动子与Ｔ７ｇ－１０释译起始序列的一段序列克隆到     

Effect of Combined Norethisterone Enantate 50mg Monthly InjectableContraceptive on Carbohydrate Metabolism

Ｅｆｆｅｃｔ　ｏｆ　Ｃｏｍｂｉｎｅｄ　Ｎｏｒｅｔｈｉｓｔｅｒｏｎｅ　Ｅｎａｎｔａｔｅ　５０ｍｇ　Ｍｏｎｔｈｌｙ　Ｉｎｊｅｃｔａｂｌｅ　ＣｏｎｔｒａｃｅｐｔｉｖｅｏｎＣａｒｂｏｈｙｄｒａｔｅＭｅｔａｂｏｌｉｓｍＳｕｎＤａｎ－ｌｉ（孙丹利）；ＳｈｅｎｇＫ...     

肠易激综合征患者结肠粘膜扫描电镜观察

应用扫描电镜观察１０例肠易激综合征（ＩＢＳ）患者降结肠粘膜的超微结构并和２例正常者进行比较性研究，结果发现ＩＢＳ组结肠粘膜上皮细胞表面微绒毛有局灶性破坏，破坏区微绒毛排列不整齐，数量稀少或缺如，结肠腺数量明显增多，腺窝开口大。腺窝处见有大量粘液分泌物和数量显著增多的杯状细胞。作者认为，ＩＢＳ并非是消化迫功能性疾病，而是有结肠粘膜超微结构改变的器质性疾病