全文获取类型
收费全文 | 16594篇 |
免费 | 1125篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 173篇 |
儿科学 | 525篇 |
妇产科学 | 293篇 |
基础医学 | 2431篇 |
口腔科学 | 352篇 |
临床医学 | 1793篇 |
内科学 | 3475篇 |
皮肤病学 | 291篇 |
神经病学 | 1509篇 |
特种医学 | 470篇 |
外国民族医学 | 3篇 |
外科学 | 2300篇 |
综合类 | 118篇 |
一般理论 | 9篇 |
预防医学 | 1982篇 |
眼科学 | 205篇 |
药学 | 897篇 |
中国医学 | 10篇 |
肿瘤学 | 923篇 |
出版年
2023年 | 169篇 |
2022年 | 222篇 |
2021年 | 424篇 |
2020年 | 305篇 |
2019年 | 422篇 |
2018年 | 442篇 |
2017年 | 417篇 |
2016年 | 392篇 |
2015年 | 456篇 |
2014年 | 566篇 |
2013年 | 764篇 |
2012年 | 1139篇 |
2011年 | 1176篇 |
2010年 | 626篇 |
2009年 | 583篇 |
2008年 | 950篇 |
2007年 | 997篇 |
2006年 | 887篇 |
2005年 | 833篇 |
2004年 | 721篇 |
2003年 | 645篇 |
2002年 | 574篇 |
2001年 | 319篇 |
2000年 | 283篇 |
1999年 | 278篇 |
1998年 | 124篇 |
1997年 | 132篇 |
1996年 | 105篇 |
1995年 | 88篇 |
1994年 | 73篇 |
1993年 | 69篇 |
1992年 | 143篇 |
1991年 | 136篇 |
1990年 | 149篇 |
1989年 | 155篇 |
1988年 | 127篇 |
1987年 | 136篇 |
1986年 | 128篇 |
1985年 | 140篇 |
1984年 | 113篇 |
1983年 | 101篇 |
1982年 | 50篇 |
1980年 | 57篇 |
1979年 | 93篇 |
1978年 | 64篇 |
1977年 | 54篇 |
1974年 | 63篇 |
1973年 | 51篇 |
1972年 | 63篇 |
1970年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Partial trisomy 6p and partial monosomy 9p from a de novo translocation 46, XY, -9, + DER(9)T(6:9)(p211:p24) 总被引:1,自引:0,他引:1
Melanie S. Eden James W. Thelin Karen Michalski Joyce A. Mitchell 《Clinical genetics》1985,28(5):375-384
This report describes an adult male with a partial trisomy 6p(p211-pter) and a partial monosomy 9p(9p24-pter) resulting from a de novo unbalanced translocation. This patient does not show the classical featured of the 9p partial monosomy syndrome, thus disputing the claim of Hoo et al. (1982) that 9p24 is the critical segment for the monosomy syndrome. Partial trisomy for 6p has only been previously reported in children. In addition to the chromosomal anomalies, the patient has autosomal recessive spinal muscular atrophy with a different age of onset than two affected sibs. Finally, he shows unusual audiologic and ophthalmologic signs nor previously reported as part of the 9p monosomy or 6p trisomy syndromes. 相似文献
92.
93.
Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB 总被引:1,自引:0,他引:1 下载免费PDF全文
94.
We have determined cutaneous DTH reactions to SK-SD and PPD and peripheral blood lymphocyte profiles in a group of asbestos workers in two consecutive surveys. It was found that asbestosis and, to a lesser extent, the presence of ANA are significantly correlated with the lack of response to the above antigens. 83% of asbestos workers when tested at a 4 year interval fell into the same two categories of responsiveness (lack of response or response at least to one antigen).The asbestosis cases had lower total lymphocyte count as well as proportions and absolute number of E-RFC as compared to asbestos workers without asbestosis and/or ANA. Furthermore, the latter group showed the lower percentages and absolute number of E-RFC than the matched controls. The presence of ANA is also correlated with lower proportions of E-RFC. However, this is related at least in part to asbestosis. 相似文献
95.
Ohne Zusammenfassung 相似文献
96.
97.
98.
Minimal residual disease in childhood B-lineage lymphoblastic leukemia. Persistence of leukemic cells during the first 18 months of treatment 总被引:8,自引:0,他引:8
M Yamada R Wasserman B Lange B A Reichard R B Womer G Rovera 《The New England journal of medicine》1990,323(7):448-455
BACKGROUND. Whether patients in clinical remission for acute lymphoblastic leukemia (ALL) continue to harbor leukemic cells is not known, because methods of detecting residual malignant cells have not been sufficiently sensitive. This information might be useful for predicting recurrence and determining the duration of therapy. METHODS. Using a sensitive new method--identifying complementarity-determining region III sequences with the polymerase chain reaction--we estimated the number of residual leukemic cells in the bone marrow of eight children with B-lineage lymphoblastic leukemia before and after remission. RESULTS. Induction chemotherapy produced a 3-to-4-log reduction in the number of leukemic cells. In all samples obtained up to 18 months after diagnosis, however, 0.004 to 2.6 percent of bone marrow nucleated cells were residual leukemic cells. Among the four patients studied more than 18 months after diagnosis, three had no detectable leukemic cells in marrow samples. Despite this, one of them, who was no longer receiving therapy, had a central nervous system relapse. In one patient receiving maintenance chemotherapy, there was a 60-fold increase in leukemic cells three months before bone marrow relapse. CONCLUSIONS. The complete disappearance of leukemic cells (or their reduction below our method's threshold of detection, 1 in 100,000 cells) may be necessary to achieve a cure of ALL. The quantification of residual leukemic cells in serial marrow aspirates during therapy may allow the early detection of relapse. 相似文献
99.
Immunogenetic studies in families with rheumatoid arthritis and autoimmune thyroid disease. 下载免费PDF全文
P A Sanders D M Grennan P A Dyer G G de Lange R Harris 《Journal of medical genetics》1985,22(6):451-456
HLA and Gm typing were carried out in 16 families. Seven families included 10 sib pairs with rheumatoid arthritis (RA) and autoimmune thyroid disease (ATD) respectively, and nine families included 16 sib pairs with RA and circulating thyroid autoantibodies respectively. Eight, 11, and seven sib pairs with either RA or clinical or immunological evidence of ATD shared none, one, and two HLA haplotypes respectively, and two, seven, and two informative sib pairs shared none, one, and two Gm haplotypes respectively. This random haplotype sharing of HLA and Gm haplotypes suggests that non-HLA, non-Gm linked genes are likely to be involved in any genetic predisposition common to RA and ATD. 相似文献
100.
This article describes the histological and ultrastructural appearance of the interface created in the implantation bed, between bone tissue and implants made of dense sintered hydroxyapatite (HA). Biopsies from dog subjects included: a) loaded permucosal dental implants for tooth substitution, b) subperiosteally placed implants for alveolar bone correction, c) endosseously placed dental root implants to retain ridge form following extraction. The light and electron microscopical results show extensive bone apposition on the osseous sides of the implant surfaces. There is an intimate, direct bone contact without any visible interruption. The bone is of normal lamellar type and continuously connected with the trabecular bone. Bone has grown into the finest surface irregularities of the implant. Collagen fibers of the calcified bone matrix are observed within a distance less than 500 A from the implant surface. The thin (20-100 A) electron dense layer at the bone-implant interface resembled the lamina limitans of organic bone matrix, also seen at the inner walls of the osteocytes lacunes. Deposition of bone gives rise to a biologically stable bone-implant interface, without disturbance of the physiological bone turnover. This is seen as very favorable for desired long term fixation of implant to bone. 相似文献