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41.
J. M. Balada-Llasat Kamal Kamboj Preeti Pancholi 《Journal of clinical microbiology》2013,51(9):2875-2879
Mycobacteria cause significant morbidity in humans. Rapid and accurate mycobacterial identification is important for improvement of patient outcomes. However, identification may be challenging due to the slow and fastidious growth of mycobacteria. Several diagnostic methods, such as biochemical, sequencing, and probe methods, are used for mycobacterial identification. We compared the matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) Biotyper system (Bruker Daltonics) to 16S rRNA/hsp65 sequencing and/or DNA probes (Gen-Probe) for mycobacterial identification. One hundred seventy-eight mycobacterial isolates grown on solid and/or broth medium were included in the study. MALDI-TOF MS identified 93.8% of the mycobacteria isolates accurately to the species level and 98.3% to the genus level, independent of the type of medium used for isolation. The identification of mycobacteria directly from cultures using MALDI-TOF MS allows for precise identification in an hour compared to traditional biochemical and phenotypic methods that can take weeks or probes and sequencing that may take a few hours. Identification by MALDI-TOF MS potentially reduces the turnaround time and cost, thereby saving resources within the health care system. 相似文献
42.
P. Meenakshi S. Ramya T. Shruthi J. Lavanya H. H. Mohammed S. A. Mohammed V. Vijayalakshmi G. Sumanlatha 《Scandinavian journal of immunology》2013,78(1):92-97
Tuberculosis (TB) constitutes the major cause of death due to infectious diseases. Cytokines play a major role in defence against Mycobacterium tuberculosis infection. Polymorphisms in the genes encoding various cytokines have been associated with tuberculosis susceptibility. Household contacts (HHC) are at increased risk of developing the disease. In this study, we examined the association of IL‐1β and IL‐10 cytokine gene polymorphisms with risk of developing tuberculosis in TB patients, their HHC and healthy controls (HC) using JavaStat and SPSS. Multifactor dimensionality reduction (MDR) analyses were performed to explore the potential gene–gene interactions. The genotype and allele frequencies of IL‐1β +3954C/T polymorphism did not vary significantly between TB patients and HC. GG (P < 0.005, OR = 0.219 and 95% CI = 0.059–0.735) and GA (P < 0.0001, OR = 2.938 and 95% CI = 1.526–5.696) genotypes of IL‐10‐1082 G/A polymorphism were found to be significantly associated with patients versus HC. HHC with CC (P < 0.03, OR = 1.833 and 95% CI = 1.1–3.35) genotype in IL‐1β and GA (P < 0.0001, OR = 4.612 and 95% CI = 2.225–9.702) genotype in IL‐10 were at increased risk of developing tuberculosis. MDR tests revealed high‐risk genotypes in IL‐1β and IL‐10 based on the association model. Our results demonstrate that the polymorphisms of IL‐1β and IL‐10 genes may be valuable markers to predict the risk for the development of TB in household contacts. 相似文献
43.
Deepali Jain MD DNB Subimal Roy MD PhD Sunita Bhalla MD Veer Singh Mehta MS Mch 《Brain pathology (Zurich, Switzerland)》2013,23(1):109-112
Medulloblastoma accounts for only 1% of all adult CNS tumors. Recently, we have encountered a case of medulloblastoma in a 26 year old man with divergent differentiation including myoblastic, glial, osteoblastic and chondroblastic differentiation. Here we present the results of immunohistochemical staining using several specific antibodies with a discussion and a review of literature. 相似文献
44.
Meenakshi Lallar Haq ul Anam Rajesh Nandal Sunder Pal Singh Surabhi Katyal 《Journal of obstetrics and gynaecology of India》2015,65(1):17-22
Objectives
To compare intravenous paracetamol and intramuscular tramadol as labor analgesics.Methods
This prospective-randomized study conducted in 200 primigravidae in active labor, distributed into two groups of 100 women each with one receiving intravenous 1,000 mg Paracetamol and other 100 mg intramuscular tramadol. Pain intensity is recorded by McGills scale before, one and 3 h after drug administration. Perinatal outcome is recorded.Results
No difference in pain intensity is seen before drug administration. After 1 h of drug administration, in paracetamol group, 4 % women had horrible pain, and 29 % had distressing pain, while in tramadol group, 30 % women had horrible pain, and 60 % had distressing pain. After 3 h of drug administration, in paracetamol group, 26 % had distressing pain, while in tramadol group, 51 % women had horrible pain, and 35 % had distressing pain. Labor duration in paracetamol and tramadol group was 4.3 and 5.9 h, respectively. In paracetamol group, nausea is seen in 2.2 % and vomiting in 1.1 %, while in tramadol group, nausea is seen in 6.4 % and vomiting in 4.3 %.Conclusions
Intravenous paracetamol is more effective labor analgesic with fewer maternal adverse effects and shortens labor as compared to intramuscular tramadol.45.
Gandham SriLakshmi Bhavani Hitesh Shah Ashwin B. Dalal Anju Shukla Sumita Danda Shagun Aggarwal Shubha R. Phadke Neerja Gupta Madhulika Kabra Kalpana Gowrishankar Anju Gupta Meenakshi Bhat Ratna D. Puri Sunita Bijarnia‐Mahay Sheela Nampoothiri Kavitha M. Mohanasundaram S. Rajeswari Akhil M. Kulkarni Muralidhar L. Kulkarni Prajnya Ranganath A. Radha Ramadevi Sankar V. Hariharan Katta Mohan Girisha 《American journal of medical genetics. Part A》2015,167(10):2481-2484
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Objective
To measure physical activity in children with wasting and to look for association between poor physical activity and wasting.Methods
Physical activity was measured in 56 children with wasting, using Children’s Activity Rating Scale, and compared with age- and sex-matched controls.Results
A significant association was found between poor physical activity and malnutrition as determined by weight-for-height Z Score <-2 (P=0.001) and midupper-arm circumference (P=0.002).Conclusion
Physical activity can be used as clinical parameter to assess malnutrition. 相似文献49.
50.