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91.
Morgan C. Willson Emily C. Bell Sanjay Dave Sheila J. Asghar Brent M. McGrath Peter H. Silverstone 《European neuropsychopharmacology》2005,15(6):633-639
Dextroamphetamine administration in healthy controls produces a range of subjective and physiological effects, which have been likened to those occurring during mania. However, it is uncertain if these can be attenuated by lithium since conflicting results have been reported. To date there have been no previous studies examining the effects of valproate on dextroamphetamine-induced mood and physiological changes. The current study was a double-blind, placebo-controlled, study in which volunteers received either 1000 mg sodium valproate (n = 12), 900 mg lithium (n = 9), or placebo (n = 12) pre-treatment for 14 days. Subjective and physiological measures were then obtained prior to administration of a 25 mg dose of dextroamphetamine, and at two time points after administration. Differences in the response to dextroamphetamine were assessed between the three treatment groups. The results of this study show that pre-treatment with lithium only significantly attenuated dextroamphetamine-induced change in happiness, while valproate pre-treatment significantly attenuated the effects of dextroamphetamine on happiness, energy, alertness and on the diastolic blood pressure. These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders. 相似文献
92.
Street JT McGrath M O'Regan K Wakai A McGuinness A Redmond HP 《Clinical orthopaedics and related research》2000,(381):278-289
Low molecular weight heparins are significantly superior to unfractionated heparin or warfarin in the prevention of thromboembolic episodes associated with orthopaedic surgery. Therapeutic doses of heparin and warfarin have been shown to delay bone repair in a rabbit model. The current study investigated the effect of prophylactic administration of a low molecular weight heparin, enoxaparin, on the healing of a closed rabbit rib fracture. Fracture healing was assessed using histomorphometric, histologic, and immunohistochemical methods at 3, 7, and 14 days, and biomechanical testing with torsional loading was assessed after 21 days. Bone repair was significantly attenuated at all times in animals receiving subcutaneous enoxaparin compared with that of the control animals. Numerous putative mechanisms for this phenomenon are discussed, and additional studies are proposed to elucidate the effects of this pharmacologically diverse group of compounds on all aspects of bone physiology and repair. 相似文献
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Cultural competency was first articulated in the 1980s to address the issues of discrimination and disparities in the provision of healthcare services. Since then, countless efforts have been made to educate and train a culturally competent healthcare task force. As the current US government unveils its healthcare reform, one might wonder what will be the future of the cultural competency in health care. The question is even more pertinent if the upcoming demographic shift of the US population is added to the picture. The most recent data from the Census Bureau stated that Asians and Hispanics are the fastest-growing ethnic groups in the US population.1 Therefore the majority of the patients receiving primary and preventive care under the changes with the Affordable Care Act will be among today’s minority groups. So more than ever before, time needs to be spent on analysis and discussion of how these important changes will shape the quality of care that ought to be culturally sensitive as an aspect of delivery of excellent care. 相似文献
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The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys
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Louisa Degenhardt Sukanta Saha Carmen C. W. Lim Sergio Aguilar‐Gaxiola Ali Al‐Hamzawi Jordi Alonso Laura H. Andrade Evelyn J. Bromet Ronny Bruffaerts José Miguel Caldas‐de‐Almeida Giovanni de Girolamo Silvia Florescu Oye Gureje Josep M. Haro Elie G. Karam Georges Karam Viviane Kovess‐Masfety Sing Lee Jean‐Pierre Lepine Victor Makanjuola Maria E. Medina‐Mora Zeina Mneimneh Fernando Navarro‐Mateu Marina Piazza José Posada‐Villa Nancy A. Sampson Kate M. Scott Juan Carlos Stagnaro Margreet Ten Have Kenneth S. Kendler Ronald C. Kessler John J. McGrath 《Addiction (Abingdon, England)》2018,113(5):924-934
98.
The cornea is the most exposed surface of the eye and, as such, is vulnerable to external trauma and the risk of infection. Many corneal diseases alter shape, surface, and transparency and thus result in reduced vision. The external position of the cornea, however, lends itself to diagnostic and therapeutic maneuvers that are commonly performed and readily done in the clinic. More sophisticated techniques require the use of complex equipment such as excimer and femtosecond laser. Complications that develop from poor healing and/or secondary infection are best avoided with appropriate technique, antisepsis, and modification of wound healing. We review corneal debridement in the management of corneal disease. 相似文献
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R. Saito A. Boyce C.‐K. Hsu E. Rashidghamat M. Hide E.K. Wedgeworth C. Flohr J.E. Mellerio J.A. McGrath 《The British journal of dermatology》2017,176(1):249-251
Basal cell naevus syndrome (BCNS) is an autosomal dominant disorder most commonly caused by a germline mutation in the Drosophila homologue of patched‐1 gene (PTCH1). Here we describe a patient with clinical signs of BCNS, caused by postzygotic mosaicism of a PTCH1 mutation. We performed restriction fragment length polymorphism analysis and Droplet Digital polymerase chain reaction to determine the degree of mosaicism in different tissues of this patient. Our case shows that a relatively low‐grade mosaicism can lead to clinical signs reminiscent of those caused by a germline mutation. This finding has important implications for genetic counselling and therefore is pivotal to recognize for dermatologists, as well as for clinical geneticists and clinical laboratory geneticists. 相似文献