全文获取类型
收费全文 | 34541篇 |
免费 | 1880篇 |
国内免费 | 280篇 |
专业分类
耳鼻咽喉 | 312篇 |
儿科学 | 700篇 |
妇产科学 | 824篇 |
基础医学 | 4062篇 |
口腔科学 | 1223篇 |
临床医学 | 2830篇 |
内科学 | 9188篇 |
皮肤病学 | 530篇 |
神经病学 | 3672篇 |
特种医学 | 1334篇 |
外科学 | 5089篇 |
综合类 | 85篇 |
一般理论 | 7篇 |
预防医学 | 1446篇 |
眼科学 | 529篇 |
药学 | 1954篇 |
中国医学 | 58篇 |
肿瘤学 | 2858篇 |
出版年
2024年 | 27篇 |
2023年 | 296篇 |
2022年 | 724篇 |
2021年 | 1192篇 |
2020年 | 678篇 |
2019年 | 991篇 |
2018年 | 1134篇 |
2017年 | 869篇 |
2016年 | 943篇 |
2015年 | 1077篇 |
2014年 | 1450篇 |
2013年 | 1858篇 |
2012年 | 2815篇 |
2011年 | 2873篇 |
2010年 | 1525篇 |
2009年 | 1471篇 |
2008年 | 2224篇 |
2007年 | 2240篇 |
2006年 | 2007篇 |
2005年 | 2050篇 |
2004年 | 1876篇 |
2003年 | 1615篇 |
2002年 | 1478篇 |
2001年 | 264篇 |
2000年 | 214篇 |
1999年 | 247篇 |
1998年 | 317篇 |
1997年 | 263篇 |
1996年 | 222篇 |
1995年 | 184篇 |
1994年 | 172篇 |
1993年 | 120篇 |
1992年 | 133篇 |
1991年 | 109篇 |
1990年 | 120篇 |
1989年 | 95篇 |
1988年 | 84篇 |
1987年 | 75篇 |
1986年 | 87篇 |
1985年 | 65篇 |
1984年 | 62篇 |
1983年 | 65篇 |
1982年 | 66篇 |
1981年 | 46篇 |
1980年 | 51篇 |
1979年 | 25篇 |
1978年 | 23篇 |
1976年 | 16篇 |
1974年 | 18篇 |
1972年 | 19篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
11.
Salvatore Greco Beatrice Bonsi Nicol Fabbri 《World Journal of Experimental Medicine》2022,12(5):104-107
Even if the relationships between nutrition and inflammatory bowel disease (IBD) remain underexplored, the current literature is providing, day by day, much more evidence on the effects of various diets in both prevention and treatment of such illnesses. Wrong dietary habits, together with other environmental factors such as pollution, breastfeeding, smoke, and/or antibiotics, are among the theoretical pathogenetic causes of IBD, whose multifactorial aetiology has been already confirmed. While some of these risk factors are potentially reversible, some others cannot be avoided, and efficient treatments become necessary to prevent IBD spread or recurrence. Furthermore, the drugs currently available for treatment of such disease provide low-to-no effect against the symptoms, making the illnesses still strongly disabling. Whether nutrition and specific diets will prove to effectively interrupt the course of IBD has still to be clarified and, in this sense, further research concerning the applications of such dietary interventions is still needed. 相似文献
12.
13.
14.
15.
Srdan Verstovsek MD PhD Jean-Jacques Kiladjian MD PhD Alessandro M. Vannucchi MD Ruben A. Mesa MD FACP Peg Squier MD PhD J. E. Hamer-Maansson MSPH Claire Harrison MD 《Cancer》2023,129(11):1681-1690
Background
In a pooled analysis of the phase 3 Controlled Myelofibrosis Study With Oral JAK Inhibitor Treatment I (COMFORT-I) and COMFORT-II clinical trials, adult patients with intermediate-2 or high-risk myelofibrosis who received oral ruxolitinib at randomization or after crossover from placebo or best available therapy (BAT) had improved overall survival (OS).Methods
This post hoc analysis of pooled COMFORT data examined relevant disease outcomes based on the disease duration (≤12 or >12 months from diagnosis) before ruxolitinib initiation.Results
The analysis included 525 patients (ruxolitinib: ≤12 months, n = 84; >12 months, n = 216; placebo/BAT: ≤12 months, n = 66; >12 months, n = 159); the median age was 65.0–70.0 years. Fewer thrombocytopenia and anemia events were observed among patients who initiated ruxolitinib treatment earlier. At Weeks 24 and 48, the spleen volume response (SVR) was higher for patients who initiated ruxolitinib earlier (47.6% vs. 32.9% at Week 24, p = .0610; 44.0% vs. 26.9% at Week 48, p = .0149). In a multivariable analysis of factors associated with spleen volume reduction, a logistic regression model that controlled for confounding factors found that a significantly greater binary reduction was observed among patients with shorter versus longer disease duration (p = .022). At Week 240, OS was significantly improved among patients who initiated ruxolitinib earlier (63% [95% CI, 51%‒73%] vs. 57% [95% CI, 49%‒64%]; hazard ratio, 1.53; 95% CI, 1.01‒2.31; p = .0430). Regardless of disease duration, a longer OS was observed for patients who received ruxolitinib versus those who received placebo/BAT.Conclusions
These findings suggest that earlier ruxolitinib initiation for adult patients with intermediate-2 and high-risk myelofibrosis may improve clinical outcomes, including fewer cytopenia events, durable SVR, and prolonged OS.Plain Language Summary
- Patients with myelofibrosis, a bone marrow cancer, often do not live as long as the general population. These patients may also have an enlarged spleen and difficult symptoms such as fatigue.
- Two large clinical trials showed that patients treated with the drug ruxolitinib lived longer and had improved symptoms compared to those treated with placebo or other standard treatments.
- Here it was examined whether starting treatment with ruxolitinib earlier (i.e., within a year of diagnosis) provided benefits versus delaying treatment.
- Patients who received ruxolitinib within a year of diagnosis lived longer and experienced fewer disease symptoms than those whose treatment was delayed.
16.
17.
18.
Psychological characteristics and physiological reactivity to acute stress in mothers of children with autism spectrum disorder 总被引:1,自引:0,他引:1
Elena Pattini Luca Carnevali Alfonso Troisi Guido Matrella Dolores Rollo Mauro Fornari Andrea Sgoifo 《Stress and health》2019,35(4):421-431
Stress related to parenting a child with autism spectrum disorder can differently affect caregiver's physiological reactivity to acute stress. Here, parental stress levels, psychological characteristics, and coping strategies were assessed alongside measures of heart rate, heart rate variability, and cortisol during a psychosocial stress test in mothers of children with ASD (M‐ASD, n = 15) and mothers of typically developing children (n = 15). M‐ASD reported significantly higher levels of parental stress, anxiety, negative affectivity, social inhibition, and a larger preference for avoidance strategies. M‐ASD showed larger heart rate and cortisol responses to the psychosocial stress test. A positive relationship was found between parental stress levels and the magnitude of the cortisol stress response in both groups. The present findings indicate exaggerated physiological reactivity to acute psychosocial stress in M‐ASD and prompt further research to explore the role of individual differences in mediating the effects of parental stress on physiological stress responses. 相似文献
19.
Rocco Spagnuolo Alessandro Corea Mariantonietta Blumetti Alessia Giovinazzo Massimiliano Serafino Caterina Pagliuso Raffaele Pagnotta Grazia Curto Cristina Cosco Vincenzo Cosco Rosellina Margherita Mancina Pietro Garieri Anna Papaleo Laura Grande Anna Barilaro Eugenio Garofalo Andrea Bruni Patrizia Doldo 《Journal of advanced nursing》2020,76(11):2993-3002
20.
Is it possible to make a diagnosis of raw,heated, and baked egg allergy in children using cutoffs? A systematic review 下载免费PDF全文