全文获取类型
收费全文 | 45716篇 |
免费 | 3404篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 595篇 |
儿科学 | 1143篇 |
妇产科学 | 557篇 |
基础医学 | 5717篇 |
口腔科学 | 494篇 |
临床医学 | 4810篇 |
内科学 | 9200篇 |
皮肤病学 | 481篇 |
神经病学 | 4480篇 |
特种医学 | 1797篇 |
外科学 | 8796篇 |
综合类 | 358篇 |
现状与发展 | 1篇 |
一般理论 | 56篇 |
预防医学 | 3809篇 |
眼科学 | 805篇 |
药学 | 2887篇 |
中国医学 | 34篇 |
肿瘤学 | 3235篇 |
出版年
2024年 | 61篇 |
2023年 | 479篇 |
2022年 | 853篇 |
2021年 | 2066篇 |
2020年 | 1069篇 |
2019年 | 1714篇 |
2018年 | 2068篇 |
2017年 | 1450篇 |
2016年 | 1472篇 |
2015年 | 1622篇 |
2014年 | 2336篇 |
2013年 | 2760篇 |
2012年 | 4369篇 |
2011年 | 4253篇 |
2010年 | 2240篇 |
2009年 | 1891篇 |
2008年 | 2976篇 |
2007年 | 3088篇 |
2006年 | 2601篇 |
2005年 | 2321篇 |
2004年 | 2031篇 |
2003年 | 1707篇 |
2002年 | 1487篇 |
2001年 | 179篇 |
2000年 | 149篇 |
1999年 | 177篇 |
1998年 | 265篇 |
1997年 | 211篇 |
1996年 | 144篇 |
1995年 | 128篇 |
1994年 | 105篇 |
1993年 | 84篇 |
1992年 | 78篇 |
1991年 | 57篇 |
1990年 | 50篇 |
1989年 | 50篇 |
1988年 | 53篇 |
1987年 | 47篇 |
1986年 | 34篇 |
1985年 | 40篇 |
1984年 | 42篇 |
1983年 | 38篇 |
1982年 | 40篇 |
1981年 | 29篇 |
1980年 | 33篇 |
1979年 | 20篇 |
1978年 | 19篇 |
1974年 | 23篇 |
1973年 | 19篇 |
1972年 | 17篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
981.
Mukundan H Price DN Goertz M Parthasarathi R Montaño GA Kumar S Scholfield MR Anderson AS Gnanakaran S Iyer S Schmidt J Swanson BI 《Tuberculosis (Edinburgh, Scotland)》2012,92(1):38-47
Lipoarabinomannan (LAM) is a critical virulence factor in the pathogenesis of Mycobacterium tuberculosis, the causative agent of tuberculosis. LAM is secreted in urine and serum from infected patients and is being studied as a potential diagnostic indicator for the disease. Herein, we present a novel ultra-sensitive and specific detection strategy for monomeric LAM based on its amphiphilic nature and consequent interaction with supported lipid bilayers. Our strategy involves the capture of LAM on waveguides functionalized with membrane mimetic architectures, followed by detection with a fluorescently labeled polyclonal antibody. This approach offers ultra-sensitive detection of lipoarabinomannan (10?fM, within 15?min) and may be extended to other amphiphilic markers. We also show that chemical deacylation of LAM completely abrogates its association with the supported lipid bilayers. The loss of signal using the waveguide assay for deacylated LAM, as well as atomic force microscopy (AFM) images that show no change in height upon addition of deacylated LAM support this hypothesis. Mass spectrometry of chemically deacylated LAM indicates the presence of LAM-specific carbohydrate chains, which maintain antigenicity in immunoassays. Further, we have developed the first three-dimensional structural model of mannose-capped LAM that provides insights into the orientation of LAM on supported lipid bilayers. 相似文献
982.
Sydney Wendt Zainub Abdullah Spencer Barrett Cyrus Daruwalla Jonathan A. Go Brandon Le Elijah Li Chelsea Livingston Matthew Miller Lauren Nakhleh Joseph Pecha Shravya Pothula Swetak Pradhan Varsha Sathappan Alay Shah Alan-Michael Sonuyi Peter Ugoh Qiancheng Wang Andrew G. Lee 《Survey of ophthalmology》2021,66(2):354-361
The coronavirus (COVID-19) pandemic temporarily suspended medical student involvement in clinical rotations, resulting in the need to develop virtual clinical experiences. The cancellation of clinical ophthalmology electives and away rotations reduces opportunities for exposure to the field, to network with faculty, conduct research, and prepare for residency applications. We review the literature and discuss the impact and consequences of COVID-19 on undergraduate medical education with an emphasis on ophthalmic undergraduate medical education. We also discuss innovative learning modalities used from medical schools around the world during the COVID-19 pandemic such as virtual didactics, online cases, and telehealth. Finally, we describe a novel, virtual neuro-ophthalmology elective created to educate medical students on neuro-ophthalmology foundational principles, provide research and presentation opportunities, and build relationships with faculty members. These innovative approaches represent a step forward in further improving medical education in ophthalmology during COVID-19 pandemic and beyond. 相似文献
983.
984.
985.
986.
987.
988.
989.
990.