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排序方式: 共有5874条查询结果,搜索用时 9 毫秒
101.
Britta Auel Hartmut Goldschmidt Thomas Geer Thomas M. Moehler Uwe Platzbecker Ralph Naumann Igor Blau Mathias H?nel Wolfgang Knauf Holger Nückel Hans-Jürgen Salwender Christof Scheid Katja Weisel Marcus Gorschlüter Axel Glasmacher Ingo G. H. Schmidt-Wolf The German Refractory Myeloma Study Group 《Indian journal of hematology & blood transfusion》2012,28(2):67-76
Treatment of relapsed or refractory multiple myeloma remains a challenge and novel treatment regimen are required. Here, a matched pair analysis was performed comparing TCID (thalidomide, cyclophosphamide, idarubicin, dexamethasone) treatment to the treatment of patients with VID (vincristine, idarubicin, dexamethasone) or with VRID (vinorelbine, idarubicin, dexamethasone) for relapsed or refractory multiple myeloma. In total, 197 patients were enrolled in multicenter trials. After matching for important prognostic variables 46 matched-pairs (total of 138 patients) could be analysed with regard to survival, toxicity and efficacy. Interestingly, a significant improvement of overall response rate (ORR) for TCID treatment compared to VID and VRID was found. In addition, TCID treatment also led to a significantly higher overall survival (OS) as well as progression-free survival (PFS) compared to VID and VRID. In conclusion, TCID treatment appears to be superior to VRID and VID treatment in patients with progressive or refractory myeloma. 相似文献
102.
Seegers J Vos MA Flevari P Willems R Sohns C Vollmann D Lüthje L Kremastinos DT Floré V Meine M Tuinenburg A Myles RC Simon D Brockm?ller J Friede T Hasenfu? G Lehnart SE Zabel M;EUTrigTreat Clinical Study Investigators 《Europace : European pacing, arrhythmias, and cardiac electrophysiology》2012,14(3):416-422
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Matthijs F. L. Meijs Willem B. Meijboom Maarten-Jan M. Cramer Francesca Pugliese Mathias Prokop Pieter A. Doevendans 《Scandinavian cardiovascular journal : SCJ》2013,47(5):277-286
Multislice Computed Tomography Coronary Angiography (CTCA) has emerged as a promising non-invasive modality for the detection of coronary artery stenosis. Image quality is still limited when compared to conventional coronary angiography. However, CTCA has been demonstrated to be highly reliable to rule out coronary artery stenosis. Technological improvements and the combination of CTCA with other non-invasive modalities are expected to further increase diagnostic accuracy. Although CTCA has clearly left the research environment, the precise role of CTCA in the diagnostic work-up of coronary artery disease needs further research. 相似文献
106.
Mathias Buttmann Imke Metz Isabel Brecht Wolfgang Brück Monika Warmuth-Metz 《Journal of the neurological sciences》2013,324(1-2):183-186
A novel type of encephalomyelitis was first described as chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in 2010 and few additional patients were reported since then. Partially due to its unknown aetiology and a lack of pathognomonic features some have suggested that CLIPPERS may not represent a distinct disease, but rather a syndrome with different underlying aetiologies. Here we report a 49-year-old German female who presented with a number of clinical and paraclinical features described as typical for CLIPPERS, while additionally showing symptoms and findings compatible with primary angiitis of the CNS (PACNS). This case may establish a previously unnoted link between two poorly understood autoimmune conditions of the CNS. 相似文献
107.
Frank Leypoldt Mathias Gelderblom Daniel Schöttle Sascha Hoffmann Klaus-Peter Wandinger 《Journal of clinical neuroscience》2013,20(4):611-613
Encephalitis associated with antibodies against N-methyl-d-aspartic acid (NMDA) receptor is characterized by severe memory deficits, decreased consciousness, epileptic seizures and movement disorders and occurs most commonly in young women. Recovery is mostly good but little is known about the disease course in patients whose treatment has been delayed severely. We present a 16-year-old girl with a 36-month follow-up. A single course of methylprednisolone attenuated some symptoms but severe and incapacitating frontotemporal syndrome remained. Second-line treatment with rituximab was initiated 12 months after the onset of symptoms. A surprising recovery occurred 18 months after treatment and 30 months after onset. Recovery in NMDA receptor antibody-associated encephalitis can be severely delayed and does not have to be linear. Whether delayed therapy contributed to recovery in this patient cannot be answered with certainty. Spontaneous recovery independent of therapy is possible, as it has been observed previously as late as 3 years after onset. Although serum antibodies disappeared with recovery in this patient, previous cases have shown serum antibodies to be unreliable markers of disease activity. Second-line treatment, especially with substances as well tolerated as rituximab, should at least be considered in NMDA receptor encephalitis with persistent neuropsychiatric syndromes after first-line therapy. 相似文献
108.
Gaunitz Franziska Thomas Andreas Fietzke Mathias Franz Florian Auwärter Volker Thevis Mario Mercer-Chalmers-Bender Katja 《International journal of legal medicine》2019,133(4):1049-1064
International Journal of Legal Medicine - Despite the increasing relevance of synthetic cannabinoids as one of the most important classes within “New Psychoactive Substances”, there is... 相似文献
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A Physiological Controller for Turbodynamic Ventricular Assist Devices Based on Left Ventricular Systolic Pressure 下载免费PDF全文
Anastasios Petrou Gregor Ochsner Raffael Amacher Panagiotis Pergantis Mathias Rebholz Mirko Meboldt Marianne Schmid Daners 《Artificial organs》2016,40(9):842-855
The current article presents a novel physiological feedback controller for turbodynamic ventricular assist devices (tVADs). This controller is based on the recording of the left ventricular (LV) pressure measured at the inlet cannula of a tVAD thus requiring only one pressure sensor. The LV systolic pressure (SP) is proposed as an indicator to determine the varying perfusion requirements. The algorithm to extract the SP from the pump inlet pressure signal used for the controller to adjust the speed of the tVAD shows robust behavior. Its performance was evaluated on a hybrid mock circulation. The experiments with changing perfusion requirements were compared with a physiological circulation and a pathological one assisted with a tVAD operated at constant speed. A sensitivity analysis of the controller parameters was conducted to identify their limits and their influence on a circulation. The performance of the proposed SP controller was evaluated for various values of LV contractility, as well as for a simulated pressure sensor drift. The response of a pathological circulation assisted by a tVAD controlled by the introduced SP controller matched the physiological circulation well, while over‐ and underpumping events were eliminated. The controller presented a robust performance during experiments with simulated pressure sensor drift. 相似文献