全文获取类型
收费全文 | 6668篇 |
免费 | 338篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 162篇 |
妇产科学 | 67篇 |
基础医学 | 760篇 |
口腔科学 | 157篇 |
临床医学 | 389篇 |
内科学 | 2032篇 |
皮肤病学 | 212篇 |
神经病学 | 589篇 |
特种医学 | 306篇 |
外科学 | 1121篇 |
综合类 | 22篇 |
预防医学 | 167篇 |
眼科学 | 52篇 |
药学 | 357篇 |
中国医学 | 9篇 |
肿瘤学 | 669篇 |
出版年
2023年 | 42篇 |
2022年 | 59篇 |
2021年 | 134篇 |
2020年 | 93篇 |
2019年 | 130篇 |
2018年 | 142篇 |
2017年 | 98篇 |
2016年 | 130篇 |
2015年 | 103篇 |
2014年 | 165篇 |
2013年 | 193篇 |
2012年 | 309篇 |
2011年 | 377篇 |
2010年 | 239篇 |
2009年 | 192篇 |
2008年 | 365篇 |
2007年 | 409篇 |
2006年 | 407篇 |
2005年 | 435篇 |
2004年 | 439篇 |
2003年 | 468篇 |
2002年 | 469篇 |
2001年 | 134篇 |
2000年 | 144篇 |
1999年 | 130篇 |
1998年 | 115篇 |
1997年 | 84篇 |
1996年 | 67篇 |
1995年 | 68篇 |
1994年 | 58篇 |
1993年 | 60篇 |
1992年 | 76篇 |
1991年 | 95篇 |
1990年 | 75篇 |
1989年 | 71篇 |
1988年 | 60篇 |
1987年 | 51篇 |
1986年 | 47篇 |
1985年 | 42篇 |
1984年 | 32篇 |
1983年 | 33篇 |
1982年 | 17篇 |
1981年 | 18篇 |
1980年 | 16篇 |
1979年 | 17篇 |
1978年 | 23篇 |
1975年 | 18篇 |
1973年 | 15篇 |
1971年 | 16篇 |
1970年 | 17篇 |
排序方式: 共有7089条查询结果,搜索用时 31 毫秒
91.
92.
Motoki Sonohata Takema Nakashima Masaru Kitajima Shunsuke Kawano Shuichi Eto Masaaki Mawatari 《Journal of orthopaedic science》2021,26(2):225-229
BackgroundPerforming total hip arthroplasty (THA) as early as possible is recommended for rapidly destructive coxarthrosis (RDC) as it causes pain that becomes progressively more severe. However, acetabular bone loss remains an issue in THA. Special devices, such as a Kerboull-type plate, may be used for acetabular bone defects, but the procedure is highly invasive and often the patients are elderly, further complicating matters. We retrospectively investigated the clinical and radiographic results of THA using conventional hydroxyapatite-coated cementless cup in RDC.MethodsA total of 32 patients (35 hips) with RDC were enrolled in the study with a minimum 10-year follow-up. All THAs were performed using conventional hydroxyapatite-coated cementless cup. All patients were evaluated clinically according to the Harris hip score (HHS). Acetabular bone deficiency was classified according to the American Academy of Orthopaedic Surgeons (AAOS) classification.ResultsEleven hips (31%) were AAOS type III, and none were type IV. Total HHS significantly improved from 36.5 to 79.4 (p < 0.01). Two cups exhibited loosening. The overall implant-associated survival rate after 10 years was 91.4%.ConclusionsClinical results of THA using conventional cementless implants for patients with RDC were acceptable. Thus, THA using conventional cementless implant is an effective and safe surgery for patients with RDC, minimizing surgical stress. 相似文献
93.
BackgroundShoulder 36 (Sh-36) is an original quality of life measure for shoulder lesions with high reliability and validity; however, in some cases, especially in those with a Bankart lesion, we observed no improvement in Sh-36 during the postoperative follow-up. Sh-36 may be less effective for a certain shoulder lesion. This study aimed to compare the reliability, validity, and responsiveness of Sh-36 among different representative diagnoses of shoulder lesions.MethodsSh-36 and the Disability of the Arm, Shoulder and Hand (DASH) were measured in 192 patients with a Bankart lesion (Bankart group), rotator cuff tear (Cuff group), and SLAP lesion (SLAP group) who underwent arthroscopic surgery. Both measures were evaluated before surgery, and at 3, 6, 9, 12, 18, and 24 months postoperatively, and reliability, validity, and responsiveness of Sh-36 and the DASH were compared among the three groups.ResultsSignificant postoperative improvement was observed in the three groups (p < 0.0001) within 9 months. No marked improvement was observed after 9 months in the Bankart and SLAP groups due to the ceiling effect; however, most domains of Sh-36 increased continuously in the Cuff group during the whole follow-up period. Reliability and construct validity were sufficient in all the groups. The longitudinal validity was sufficient in most domains for the three groups; however, the standardized response mean in the Bankart group was lower than that in other two groups, indicating low responsiveness in this group because of the ceiling effect.ConclusionsSh-36 was a valid and reliable instrument in patients who have undergone arthroscopic shoulder surgery, especially for patient with a rotator cuff tear with high responsiveness. However, Sh-36 had lower standard response mean representing lower responsiveness in the Bankart group due to the ceiling effect and may not be ideal for longitudinal follow-up in patients with a Bankart lesion. 相似文献
94.
Hara Masatoshi Tanaka Shigeru Torisu Kumiko Matsukuma Yuta Tsuchimoto Akihiro Tokumoto Masanori Ooboshi Hiroaki Nakano Toshiaki Tsuruya Kazuhiko Kitazono Takanari 《Clinical and experimental nephrology》2021,25(8):822-834
Clinical and Experimental Nephrology - A growing body of evidence has shown that non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). Non-invasive fibrosis... 相似文献
95.
96.
Kouji Katsura Yoshihiko Soga Sadatomo Zenda Hiromi Nishi Marie Soga Masatoshi Usubuchi Sachiyo Mitsunaga Ken Tomizuka Tetsuhito Konishi Wakako Yatsuoka Takao Ueno Tadanobu Aragaki Takafumi Hayashi 《Journal of radiation research》2021,62(2):374
The aim of this study was to compare the estimated public medical care cost of measures to address metallic dental restorations (MDRs) for head and neck radiotherapy using high-energy mega-voltage X-rays. This was considered a first step to clarify which MDR measure was more cost-effective. We estimated the medical care cost of radiotherapy for two representative MDR measures: (i) with MDR removal or (ii) without MDR removal (non-MDR removal) using magnetic resonance imaging and a spacer. A total of 5520 patients received head and neck radiation therapy in 2018. The mean number of MDRs per person was 4.1 dental crowns and 1.3 dental bridges. The mean cost per person was estimated to be 121 720 yen for MDR removal and 54 940 yen for non-MDR removal. Therefore, the difference in total public medical care cost between MDR removal and non-MDR removal was estimated to be 303 268 800 yen. Our results suggested that non-MDR removal would be more cost-effective than MDR removal for head and neck radiotherapy. In the future, a national survey and cost-effectiveness analysis via a multicenter study are necessary; these investigations should include various outcomes such as the rate of local control, status of oral mucositis, frequency of hospital visits and efforts of the medical professionals. 相似文献
97.
Motonobu Kameyama Kiichi Ishiwata Yuji Tsurumi Jun Itoh Kiyotaka Sato Ryuichi Katakura Takashi Yoshimoto Jun Hatazawa Masatoshi Ito Tatsuo Ido 《Journal of neuro-oncology》1995,23(1):53-61
Summary Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism. 相似文献
98.
Anterior Transhepatic Approach for Isolated Resection of the Caudate Lobe of the Liver 总被引:15,自引:4,他引:11
Junji Yamamoto Tomoo Kosuge Kazuaki Shimada Susumu Yamasaki Tadatoshi Takayama Masatoshi Makuuchi 《World journal of surgery》1999,23(1):97-101
RID=" ID=" <E5>Correspondence to:</E5> J. Yamamoto, M.D. 相似文献
99.
Activation of the reticulothalamic cholinergic pathway by the major metabolites of aniracetam 总被引:3,自引:0,他引:3
The aim of the study was to further investigate the effects of aniracetam, a cognition enhancer, and its metabolites on the brain cholinergic system. We measured choline acetyltransferase activity and acetylcholine release using in vivo brain microdialysis in stroke-prone spontaneously hypertensive rats (SHRSP). The enzyme activity in the pons–midbrain and hippocampus, and basal acetylcholine release in the nucleus reticularis thalami were lower in SHRSP than in age-matched Wistar Kyoto rats, indicating central cholinergic deficits in SHRSP. Repeated treatment of aniracetam (50 mg/kg p.o.×11 for 6 days) preferentially increased the enzyme activity in the thalamus, whereas decreased it in the striatum. Among the metabolites of aniracetam, local perfusion of N-anisoyl-γ-aminobutyric acid (GABA, 0.1 and/or 1 μM) and p-anisic acid (1 μM) into the nucleus reticularis thalami, dorsal hippocampus and prefrontal cortex of SHRSP produced a significant but delayed increase of acetylcholine release. We failed, however, to find any effect of aniracetam itself. A direct injection of N-anisoyl-GABA (1 nmol) into the pedunculopontine tegmental nucleus of SHRSP enhanced the release in the nucleus reticularis thalami. Thus, these data prove that aniracetam can facilitate central cholinergic neurotransmission via both metabolites. Based on its pharmacokinetic profile, N-anisoyl-GABA may contribute to the clinical effects of aniracetam, mainly by acting on the reticulothalamic cholinergic pathway. 相似文献
100.
Role of Ca2+-activated K+ channels in acetylcholine-induced dilatation of the basilar artery in vivo
下载免费PDF全文
![点击此处可从《British journal of pharmacology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Takanari Kitazono Setsuro Ibayashi Tetsuhiko Nagao Kenichiro Fujii Masatoshi Fujishima 《British journal of pharmacology》1996,120(1):102-106
- We tested the hypothesis that activation of large conductance calcium-activated potassium channels is involved in dilator responses of the basilar artery to acetylcholine in vivo. Using a cranial window in anaesthetized rats, we examined responses of the basilar artery to acetylcholine.
- Topical application of acetylcholine (10−6 and 10−5 M) increased diameter of the basilar artery from 238±7 μm to 268±7 and 288±7 μm, respectively (P<0.05 vs. baseline diameter). Iberiotoxin (10−8 M), an inhibitor of large conductance calcium-activated potassium channels, did not affect baseline diameter of the basilar artery. In the presence of 10−8 M iberiotoxin, 10−6 and 10−5 M acetylcholine increased diameter of the basilar artery from 239±7 μm to 246±7 and 261±7 μm, respectively. Thus, iberiotoxin attenuated acetylcholine-induced dilatation of the basilar artery (P<0.05).
- Sodium nitroprusside (10−7 and 10−6 M) increased diameter of the basilar artery from 242±9 μm to 310±12 and 374±13 μm, respectively (P<0.05 vs. baseline diameter). In the presence of iberiotoxin (10−8 M), sodium nitroprusside (10−7 and 10−6 M) increased diameter of the basilar artery from 243±6 μm to 259±9 and 311±12 μm, respectively. Thus, iberiotoxin attenuated dilator responses of the basilar artery to sodium nitroprusside (P<0.05).
- Iberiotoxin partly inhibited dilator responses of the basilar artery to forskolin, a direct activator of adenylate cyclase, but did not affect vasodilatation produced by levcromakalim, a potassium channel opener.
- These results suggest that dilator responses of the basilar artery to acetylcholine and sodium nitroprusside are mediated, in part, by activation of large conductance calcium-activated potassium channels. Because both acetylcholine and sodium nitroprusside have been shown to activate guanylate cyclase via nitric oxide, activation of large conductance calcium-activated potassium channels may be one of the major mechanisms by which cyclic GMP causes dilatation of the basilar artery in vivo.