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991.
Vascular Endothelial Growth Factor Levels in Childhood Acute Lymphoblastic and Myeloblastic Leukemia
Göksel Leblebisatan Bülent Antmen İlgen Şaşmaz Yurdanur Kilinç 《Indian journal of hematology & blood transfusion》2012,28(1):24-28
Angiogenesis has been associated with the growth, dissemination and metastasis and has been shown to be a prognostic. Although
there are some data suggesting that angiogenesis may have a role in the pathophysiology of leukemia, its role in patient prognosis
is yet to be defined. We analyzed the expression level of vascular endothelial growth factor (VEGF), an angiogenesis promoter
and its possible- prognostic value in bone marrow samples at the time of diagnosis and remission of acute childhood leukemia
patients. Besides 46 patients diagnosed as ALL or AML, 16 children were also included as a control group in the study. Our
data have demonstrated that VEGF levels of AML patients were found higher than the control group statistically (P = 0.022). However we could not find any significant difference between VEGF levels of diagnosis and remission in both AML
and ALL groups by blastic VEGF expression (P > 0.05). In this study the higher levels of VEGF in AML patients is one of the main findings although we were not able to
assess any role of VEGF in predicting prognosis in pediatric leukemia patients by evaluating blastic cell VEGF expression.
These results have demonstrated that the relationship between angiogenesis or angiogenesis promoters and hematological malignancies
is not clear and simple as different methods or different cells beside different angiogenesis promotors are involved to these
studies. So that not only tumor cells and their cytokines but also surrounding cells and their cytokines must be taken into
consideration with the standardized study methods in the further studies to obtain a promising treatment approach. 相似文献
992.
Iliana Alexoudi Violetta Kapsimali Aristides Vaiopoulos Meletios Kanakis George Vaiopoulos 《Clinical rheumatology》2011,30(2):157-163
Behçet’s disease (BD) is a chronic relapsing vasculitis with multifunctional pathogenesis. The mucocutaneous and ocular lesions are the commonest manifestations, but BD also affects the musculoskeletal, intestinal, cardiac, and central nervous system. BD therapy is based on the suppression of the inflammatory process, using immunomodulating and immunosuppressive agents. In selected cases, invasive procedures may be required. 相似文献
993.
We report a case of acquired thrombotic thrombocytopenic purpura (TTP) in a 34-year old patient with a prior diagnosis of
systemic lupus erythematosis (SLE) who was recently started on hydroxychloroquine. Presenting symptoms included fevers, sore
throat and productive cough with progressive weakness, dyspnea on exertion, hemoptysis and dark urine. Initial laboratory
abnormalities were consistent with an acute microangiopathic hemolytic anemia and severe thrombocytopenia. At the time of
admission, the patient’s lupus was highly active as evident by his high SLE Disease Activity Index (SLEDAI) score. He was
later also found to have severely reduced ADAMTS-13 levels and a positive antibody assay. This case highlights the occasional
difficulty in pinpointing the exact etiology of TTP as well as establishes a possible novel drug association between hydroxychloroquine
and TTP development. 相似文献
994.
995.
Nisha Marwah Shilpi Modi Veena Gupta Sumiti Gupta Gajender Singh Rajeev Sen 《Indian journal of hematology & blood transfusion》2012,28(1):47-49
We report a case of a newborn male who had mongoloid slant and was hypotonic at birth. Routine investigations revealed leucocytosis
(WBC > 70,000/cmm) with 50% blasts in peripheral blood film. Marrow examination confirmed the excess of blasts. Karyotyping
revealed 47, XY + 21 chromosomes. Due to absence of clinical symptoms, the baby was kept on follow-up without treatment. Within
7 weeks, PBF and bone marrow findings returned to normal, and the child was diagnosed as having Transient leukaemia with Down
syndrome. 相似文献
996.
This study is focused on the properties of the monobloc hydrogel (MH) breast implant, which has been around for more than
30 years, and to see how it behaves with regard to health complaints as sometimes seen in some patients who had received silicone
gel (SG) breast implants. Patients responded to a questionnaire examining their experience with breast implants. Three groups
were included. First, the control group (n = 34) of women without breast implants. Second, a C group of women (n = 42) who began and remained on the MH implant. Third, the B group of women who had their silicone gel implant replaced by
the MH implant. In the B1 subgroup (n = 22), a capsulectomy was also performed. In the B2 subgroup (n = 13), the replacement was carried out without a capsulectomy. The C group behaved very much like the control group. The
women of the B group experienced an improvement of their complaints and the improvement was even better after a capsulectomy.
The only difference between the MH and SG implants is the content of the implant. The satisfaction of women with MH implants
is generally high and not or hardly associated with health complaints. In women with SG implants and health complaints, these
complaints can be relieved by replacement of the implants by MH implants. 相似文献
997.
Hiroki Tojima Satoru Kakizaki Takashi Kosone Norio Horiguchi Yuichi Yamazaki Ken Sato Hitoshi Takagi Masatomo Mori 《Hepatology International》2012,6(3):620-630
Background
Hepatocyte growth factor (HGF) is a potent growth factor involved in liver regeneration that has various effects on epithelial and nonepithelial cells. Although it has been demonstrated that HGF can reduce liver inflammation or fibrosis caused by pharmaceutical or chemical insult, no examination of its effect on liver injury in nonalcoholic steatohepatitis (NASH) has been reported. 相似文献998.
Urodynamic studies (UDS) have been used to objectively characterize a patient’s complaint of urinary incontinence. Presumably, the clinician can utilize the UDS data to guide treatment options. It is even hoped that UDS can help predict which treatments should be utilized to produce the most effective outcomes. However, is this currently the case? The Urinary Incontinence Treatment Network (UITN) has completed four large randomized clinical trials related to treatments for urinary incontinence. Two trials compared outcomes of different surgeries for stress urinary incontinence (SUI) in which standardized UDS protocols were used. Secondary analyses of these UDS data showed that UDS were neither prognostic of treatment outcomes nor correlative with severity of UI symptoms, suggesting limited utility of UDS in the evaluation and management of the uncomplicated SUI patient. A third trial was designed to answer whether a basic office examination is not noninferior to UDS in affecting SUI surgical outcomes. The results of this study are currently in press. A fourth trial examined treatment of urgency urinary incontinence (UUI). Because UDS was not part of this trial, the utility of UDS in management and treatment of UUI could not be assessed. In summary, UDS will need to undergo further refinements to increase its clinical effectiveness in the area of urinary incontinence. 相似文献
999.
T. Pech J. Fujishiro T. Finger I. Ohsawa M. Praktiknjo M. von Websky S. Wehner K. Abu-Elmagd J. C. Kalff N. Schaefer 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2012,397(1):131-140
Purpose
Ischemia-reperfusion injury leads to impaired smooth muscle function and inflammatory reactions after intestinal transplantation. In previous studies, infliximab has been shown to effectively protect allogenic intestinal grafts in the early phase after transplantation with resulting improved contractility. This study was designed to reveal protective effects of infliximab on ischemia–reperfusion injury in isogenic transplantation. 相似文献1000.