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51.
52.
Shin-ichi Niwa Masataka Ohta Kiyoyuki Yamazaki 《Journal of autism and developmental disorders》1983,13(1):33-42
Cognitive functioning in autistic subjects was investigated by employing ERP recordings. The sample included four autistic patients, with five normal subjects and four Down's syndrome patients serving as the two control groups. The P300 component was investigated under three different experimental conditions, that is; “No-task,” “Counting,” and “Key-press. ” Two out of four autistic subjects were able to perform the required task under the Counting condition. However, none of them were able to complete the task for the Key-press condition. Autistic subjects demonstrated a lower amplitude of the P300 component under the No-task condition as compared to the other two groups. It was speculated that the autistic, as opposed to the other two groups, had some cognitive difficulties in the “active stimulus evaluating process”. 相似文献
53.
Shin-ichi Hirano Naoki Agata Yutaka Hara Hiroshi Iguchi Masataka Shirai Hiroshi Tone Norimoto Urakawa 《Cancer chemotherapy and pharmacology》1991,28(4):266-272
Summary In the present study we examined the effects of pirarubicin [(2R)-4-0-tetrahydropyranyladriamycin, THP] on a cardiovascular system. An injection of THP (0.39–3.13 mg/kg, i. v.) reduced the mean blood pressure and caused an increase in the respiratory air rate in anesthetized rats. At 1.5×10–6–1.5×10–5
m, THP markedly relaxed a contraction induced by 10–7
m norepinephrine in rat aorta with endothelium but not in that without endothelium. At a dose of 0.02–0.5 mg, THP produced an increase in the contractile force and the perfusion flow of isolated perfused guinea pig hearts. At a higher concentration (4.5×10–5–1.5×10–4
m), it produced a slight increase in the contractile force of the left atria in guinea pigs. This positive inotropic action of THP was inhibited by diphenhydramine (10–6–5×10–5
m), chlorpheniramine (3×10–7–3×10–5
m), and tripelennamine (3×10–7–3×10–5
m) but not by propranolol (10–6
m), cimetidine (10–5
m), diltiazem (10–6
m), or ryanodine (10–8
m). THP given i. v. at 2.5 mg/kg elevated the plasma histamine level in anesthetized dogs. From these data, we conclude that THP mainly relaxed the rat aorta in the presence of endothelium and that at higher concentrations, it increased the contractile force in the cardiac muscle, probably mediated through the release of histamine. 相似文献
54.
Hirose M Yoda K Sakai K Saitoh A Nakagawa H Tanaka M Miyazaki M 《Journal of anesthesia》1991,5(1):30-35
Prostaglandin E1-induced hypotension (25% reduction from the preadministration level in mean arterial pressure) was applied to thirteen patients. Eight patients among them were operated in the supine position (group I) and other five in the prone position (group II). The maintenance dose of PGE1 was considerably lower in group II than in group I (0.067µg·kg–1·min–1 vs. 0.119µg·kg–1·min–1). In group I, there was a significant increase in CI, with a significant decrease in SVRI and PVRI during PGE1-induced hypotension. Such a high dose of PGE1 (0.119µg·kg–1·min–1) was considered to have a direct dilating action on the systemic resistance bed as well as on the pulmonary vasculature. It was considered that the suppression of hypoxic pulmonary vasoconstriction could be a mechanism to increase venous admixture during PGE1-induced hypotension. In group II, there was no significant increase in CI, and no significant decrease in SVRI and PVRI. PGE1-induced hypotension can be safely applied to the anesthetized patients, but we should be careful to apply it to the patients in the prone position, because lower dose of PGE1 can induce severe hypotension, which is not accompanied by the increase in CI as occures in the patients in the supine position.(Hirose M, Yoda K, Sakai K, et al.: Comparative Study on the cardio-respiratory change during prostaglandin E1-induced hypotention in the patients in the supine and prone position. J Anesth 5: 30–35, 1991) 相似文献
55.
Abul Mokarim Masataka Uetani Ichiro Sakamoto Nobuyuki Hayashi Koichiro Nomata Hiroshi Ohtani 《Acta oncologica (Stockholm, Sweden)》1997,36(2):175-181
Forty-five patients (median age 63 years) with muscle invasive bladder cancer were treated with transcatheter intraarterial infusion (TAI) of cisplatin (CDDP) and doxorubicin. They received a total of 114 courses (median 3 courses per patient) of TAI. Complete response was obtained in 20 patients (44%), partial response in 17 (38%), stable disease in 6(13%), and progression of disease in 2 patients (5%). The overall response rate was 82% at a median follow-up of 36 months. The actuarial survival of the patient population was 72% at 5 years; 36 patients were alive and 9 had died of cancer progression. The treatment was generally extremely well tolerated without major complications. The current study also revealed the fact that papillary carcinomas were more sensitive to this therapy than were non-papillary tumors. Overall, response rate and local control were significantly higher in low-grade than in high-grade tumors. The observed high complete response and good survival rate suggest that intraarterial CDDP and doxorubicin might be highly effective for localized invasive bladder cancer. 相似文献
56.
Kiyoshi Ohara Hideo Tatsuzaki Hiroshi Fuji Shinji Sugahara Toshiyuki Okumura Eiichi Akaogi Masataka Onizuka Shigemi Ishikawa Kiyofumi Mitsui Yuji Itai 《Acta oncologica (Stockholm, Sweden)》1998,37(5):471-474
Patterns of radiologic response of 10 thymomas treated by preoperative radiotherapy (RT) (18-20 Gy/2 weeks) were determined in conjunction with histologic response. Changes in tumor volume were evaluated with CT scans obtained 5 to 36 days before and 14 to 24 days after the initiation of RT and before surgery. The extent of tumor volume reduction (TR) varied widely (40-78%), while the mean daily volume decrement expressed as a percentage of the pre-RT tumor volume correlated significantly with the pre-RT tumor volume. Histologically, the tumors, all of which were resected 17 to 33 days after RT initiation, generally consisted of predominant fibrous tissues, rare necrotic foci, and few epithelial cells. The TR did not correlate with pre-RT tumor volume, observation period, histologic subtype, or quantity of remaining epithelial cells. The TR of thymomas does not predict RT impact on tumor cells but does reflect the quantity of inherent tumor stroma. 相似文献
57.
58.
Masataka Taga Hidetaka Eguchi Tomoko Shinohara Keiko Takahashi Reiko Ito Wataru Yasui Kei Nakachi Yoichiro Kusunoki Kiyohiro Hamatani 《International journal of clinical and experimental pathology》2013,6(1):76-79
Archival tissue specimens are valuable resources of materials for molecular biological analyses in retrospective studies, especially for rare diseases or those associated with exposure to uncommon environmental events. Although successful amplification with PCR is essential for analysis of DNA extracted from archival formalin-fixed, paraffin-embedded (FFPE) tissue specimens, we have often encountered problems with poor PCR amplification of target fragments. To overcome this, we examined whether heat treatment in alkaline solution could efficiently restore the PCR template activity of DNA that had already been extracted from FFPE lung cancer tissue specimens. The effect of the heat treatment was assessed by PCR for the TP53 gene and other lung cancer-related gene loci. The heat treatment of DNA samples in borate buffer resulted in successful PCR amplification of DNA fragments ranging from 91 to 152 bp. This technique for restoration of template activity of DNA for PCR amplification is very simple and economical, and requires no special apparatus, so it may be applicable for molecular analysis of DNA samples from FFPE tissue specimens at various laboratories. 相似文献
59.
Real‐world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus‐infected cirrhosis patients
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Kei Morio Michio Imamura Yoshiiku Kawakami Reona Morio Tomoki Kobayashi Satoe Yokoyama Yuko Nagaoki Tomokazu Kawaoka Masataka Tsuge Akira Hiramatsu Grace Naswa Makokha C Nelson Hayes Hiroshi Aikata Daiki Miki Hidenori Ochi Yoji Honda Nami Mori Shintaro Takaki Keiji Tsuji Kazuaki Chayama 《Journal of gastroenterology and hepatology》2017,32(3):645-650
60.
Coffee leaf rust is for the coffee industry potentially one of the causes of a sustainability crisis. Currently, on-site disease detection is the only effective method to fell coffee trees for prevention of the infection. However, accurate infection detection over wide areas is difficult when conducted by ground surveys. Here, we examine the application of a remote sensing method. The Normalized Difference Vegetation Index (NDVI) values of coffee farms were computed using satellite images and compared with the results of the ground truth. We found that the standard deviation of the NDVI value (σNDVI) in damaged farms increases as the average NDVI value decreases. This fact implies that the disease progresses in-homogeneously inside a damaged area. In the present analysis, up to 94.1% of the damaged farms were discriminated by combining the NDVI and σNDVI thresholds when 75.0% of the damaged farms had NDVI values under 0.732 and σNDVI over 0.044. Our monitoring method enabled us to take early-stage countermeasures against the infection, and it could be applied to other vegetation diseases. 相似文献