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91.
Kurata M 《Journal of anesthesia》1993,7(3):325-333
31P and 23Na nuclear magnetic resonance (NMR) spectroscopy was employed to study the dynamic changes in intracellular high-energy phosphates and sodium during 15min of forebrain ischemia and recirculation in in vivo rat brain. In the presence of the shift reagent Dysprosium triethylenetetramine-N,N,N,N,N,N-hexaacetic and [Dy(TTHA)], the sodium peak separated into two peaks, unshifted and shifted. During 15min of ischemia, the unshifted sodium peak decreased and the shifted sodium peak increased. With recirculation, the unshifted and the shifted sodium peaks returned to the preischemia level within 10min, but the shifted one increased during 30–60min. Intracellular high-energy phosphates and intracellular pH (pHi) decreased during 15min of ischemia and returned to the preischemia levels within 20min of recirculation. We conclude that the decrease in unshifted sodium peak during ischemia is due to the decrease in subarachnoid sodium and the cellular influx of interstitial sodium would be minimum. The increase in shifted sodium peak during ischemia is considered to be due to the dilatation of cerebral blood vessels and the increase in interstitial sodium which was transported from subarachnoid space.(Kurata M: 31P and 23Na nuclear magnetic resonance study on forebrain ischemia in rats with shift reagent Dy(TTHA). J Anesth 7: 325–333, 1993) 相似文献
92.
Iwabuchi Satoru Handa Masashi Usuda Katsuo Sato Masami Kondo Takashi Tanita Tatsuo Fujimura Shigefumi 《Surgery today》1994,24(11):1014-1018
A 52-year-old Japanese man with a slow-growing chondroma originating from the sternal bone was referred to our hospital. A subtotal resection of the sternum was performed, hereafter termed the sandwich method, and an originally designed prosthesis made from ultra-high-molecular-weight polyethylene and Marlex mesh was used for reconstruction. The postoperative course was uneventful without any symptoms due to paradoxical movement of the chest or regional abscess, and no disturbance in the movement of the upper limbs, such as a surgical sequelae, was observed. 相似文献
93.
Takafumi Ichida Masashi Kato Akihito Hayakawa Shinichi Ito Shigeki Mori Tomomi Sato Souichi Sugitani Hiroshi Sato Masashi Watanabe Hitoshi Asakura 《Cancer chemotherapy and pharmacology》1994,33(Z1):S74-S78
Prior injection of an anticancer agent and Lipiodol mixture is a key point for the treatment of hepatocellular carcinoma (HCC). We therefore prepared a new, improved emulsion of Lipiodol containing a high dose ofcis-diamminedichloroplatinum (CDDP) and epirubicin by replacing the ionic contrast medium (Urografin 67) with a nonionic contrast medium (Iopamidol; Iopamiron 300) and adding phosphatidyl choline. This CDDP-epirubicin-Lipiodol emulsion (CELE) was examined pharmacologically and chemically with the following results. The size of these particles is less than 10 m (diameter) for up to 24 h; the release of 28%–34% of the CDDP and 80%–90% of the epirubicin was estimated in the dissolution test, and 85% of the CDDP and 35% of the epirubicin was retained in the organs in the moment calculation. CELE was injected into 58 HCC patients via a celiac angiographic catheter. In 36 of these patients, the CELE injection was followed by transcatheter arterial embolization (TAE) therapy. Following the administration of CELE as one-shot injection therapy for stage IV HCC, the 1-year survival rate was 59% and the 2-year survival rate was 27%. Moreover, in patients (stage II, 12; stage III, 8; stage IV, 16) who received CELE and subsequently underwent TAE therapy, the 1-year survival rate was 90% and the 2-year survival rate was 67%. The nonionic contrast medium with Lipiodol forms finer emulsified particles, and these particles are more capable of penetrating into the tumor. In addition, the greater pharmacological stability of these particles provides a slow-release effect and prolonged stability of their shape. Finally, theoretically, the use of two major anticancer agents such as CDDP and epirubicin showed a greater clinical effect in the treatment of HCC than either our earlier suspension or a single anticancer agent.Work presented at the Third International Symposium on Treatment of Liver Cancer, Seoul, Korea, 12–13 February 1993 相似文献
94.
Shiomi H Hase T Matsuno S Izumi M Tatsuta T Ito F Kishida A Tani T Kodama M 《Surgery today》1999,29(12):1280-1284
An 18-year-old male was admitted to our Emergency Department with a traumatic abdominal wall hernia (TAWH) of the left lower
quadrant (LLQ) after suffering hypogastric blunt injury and urogenital lacerations in a motorcycle accident. Upright chest
X-ray showed a small amount of right infradiaphragmatic free air, and a computed tomographic (CT) scan demonstrated an abdominal
wall hernia. At surgery, no impairment was found in the digestive tract, and an abdominal herniorrhaphy was performed. It
is suggested that the free air had passed through a connection between the scrotal laceration and the contralateral abdominal
defect via the subcutaneous space and was palpated as emphysema. This is a new type of TAWH, which suggests that blunt abdominal
trauma may result in negative pressure in the subcutaneous and peritoneal cavity, and this could reflect the pathophysiology
of TAWH. 相似文献
95.
Sakakibara H Zhu SK Furuta M Kondo T Miyao M Yamada S Hideaki T 《Environmental health and preventive medicine》1996,1(3):114-118
Factors associated with knee pain were investigated using 871 self-administered questionnaires (405 men and 466 women) from
residents aged over 30 years in a rural area of Japan. The prevalence of knee pain increased with age, particularly in women
over 50. It was significantly higher in women than in men. Body mass index (BMI) was significantly related to knee pain in
women, though not in men. With reference to occupational factors, frequent heavy lifting on the job was significantly associated
with knee pain in both men and women, whereas job-related standing and walking showed no such relationship. As for living
conditions, residence on rather steep mountain slopes and the habit of sitting on Japanese tatami mats were significant factors
related to knee pain in men, but not in women. There was no association of knee pain with the style of toilet (Japanese or
Western). After controlling for all significant factors by multiple logistic regression analysis, age, heavy lifting, and
residence on steep slopes were found to be independent factors related to knee pain in men; and age, BMI, and heavy lifting
were the factors in women. 相似文献
96.
Masashi Takamatsu Mitsuru Ohata Kazuhiko Sakamoto Yasuyuki Searashi Kunihiko Takeda Hideaki Suzuki Hisato Nakajima Masayoshi Yamauchi Ken Hokkyo Gotaro Toda Noritoshi Shinkai 《Nihon Arukōru Yakubutsu Igakkai zasshi》2003,38(6):492-497
A case of female alcoholic who developed liver cirrhosis with small amounts of alcohol by the common use of contraceptive agent was reported. A case was a 33-year-old female who had complained of systemic edema and jaundice. She had been drinking alcohol, while she had been taking the contraceptive agent from 20-year-old. On admission, she had a large amount of ascites with jaundice. She was diagnosed as liver cirrhosis and hepatic failure by CT scanning of abdomen and laboratory data. Her condition was temporarily improved by the abstinence and the treatment. Since she drank under hospitalization, she had to change the hospital and died after 2 months. She had been drinking for only 10 years. Her cumulative alcohol intake was also very small. She may have developed alcoholic cirrhosis with small amount of alcohol because of common use of contraceptive agent with drinking. 相似文献
97.
98.
Keiichi Ichimura Masashi Sugasawa Ken-ichi Nibu Esao Takasago Kenji Hasezawa 《Auris, nasus, larynx》1997,24(4):391-397
We sometimes experience patients with persistent or progressive arytenoid edema, among which residual or recurrent cancer is often accompanied. Because it is difficult to distinguish tumour rest or recurrence from normal tissue sequelae in the early period after irradiation, it is important to know both the contributing factors for arytenoid edema, and the incidence of residual or recurrent tumours in patients with postirradiation laryngeal edema. We therefore reviewed the charts of 67 patients with early laryngeal carcinoma who had received a curative dose of irradiation in the last 5 years. Fourteen patients (20.9%) had moderate or severe laryngeal edema persisting for or developing at more than 3 months after completion of a course of definitive radiotherapy. The incidence was highest in supraglottic T2 disease, followed by glottic T2 tumour. Of the 14 patients with edema, six (42.9%) had persistent or recurrent disease. The primary disease was uncontrolled in 18 patients, 17 of whom received successful salvage surgery. In patients without residual tumours, the edema was usually moderate and resolved within a year, although four patients had chronic edema lasting more than a year after treatment. All four had supraglottic T2 lesions and received 70 Gy of X-ray. We also reviewed, for sake of comparison, the records of 38 patients treated with radiotherapy at doses of more than 40 Gy between l975 and 1980, when endoscopic microsurgery for laryngeal cancer was introduced as a primary part of treatment. The incidence of persistent or late developed edema over the period, though not significant, was 36.8%: nearly twice that of the last 5 years. Microscopic endolaryngeal surgical procedures seem to have been a causal factor for edema in this period. 相似文献
99.
Fujio Kakuya Masashi Takase Noriyuki Ishii Mayumi Kajino Tokitsugi Hayashi Kazutoshi Miyamoto Senichi Muraki Jun Iwamoto Akimasa Okuno 《Pediatrics international》1998,40(2):155-158
Abstract The delivery of nitric oxide (NO) via a nasopharyngeal tube is an alternative to endotracheal intubation. A male infant with end-stage pulmonary hypertension (PH) due to a severe hypoplastic lung developed a PH crisis on day 145 and received NO inhalation via a nasopharyngeal tube. Clinical improvement was maintained for 7 days with18–22ppm NO inhalation. The patient remained in close physical contact with his parents without the use of sedation. Blood methemoglobin levels remained below 1%. The environmental NO levels were less than 0.06 ppm and NO2 less than 0.3 ppm throughout the treatment, well within the safety margin. On day 152, the patient succumbed to hypoxemia and heart failure. The use of a nasopharyngeal NO delivery system without sedation, as an alternative to endotracheal intubation with sedation, was a practical method in treating a patient with PH while maintaining a certain quality of life for the patient and the family. 相似文献
100.
Sequence Analysis of Genes Encoding Rodent Homologues of the Human Tumor-rejection Antigen SART-1 总被引:2,自引:0,他引:2
Masashi Gotoh Shigeki Shichijo Tomoaki Hoshino Yasuhisa Imai Toshihiro Imaizumi Yoshiko Inoue Hideo Takasu Takashi Yamaoka Kyogo Itoh 《Cancer science》1998,89(8):849-854
Human SART-1 ( hSART-1 ) gene encodes a 125 kD protein with a leucine-zipper motif expressed in the nucleus of all proliferating cells, and a 43 kD protein expressed in the cytosol of most epithelial cancers. In this study, two rodent genes ( rSART-1 and mSART-1 ) homologous to hSART-1 were cloned from cDNA libraries of murine brain and a rat tumor cell line, respectively. mSART-1 and rSART-1 were highly homologous to hSART-1 with 86% and 84% identity at the nucleotide level, and 95% and 91% at the protein level, respectively. The leucine zipper domain and two basic amino acid portions that bind DNA, as well as peptide sequences recognized by human cyto-toxic T lymphocytes (CTLs), were all conserved in these rodent genes. Nuclear protein homologous to the 125 kD hSART-1800 protein, but not to the 43 kD cytosol SART-1259 protein, was detectable with specific antibody in the nuclear fractions of rodent tumor cell lines, and normal rodent fetal liver and testis. These rodent genes should be a novel tool for studies on the biological roles of the SART-1 gene, and also in the construction of animal models of specific immuno-therapy using SART-1 gene products. 相似文献