全文获取类型
收费全文 | 8424篇 |
免费 | 435篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 221篇 |
妇产科学 | 88篇 |
基础医学 | 1090篇 |
口腔科学 | 182篇 |
临床医学 | 473篇 |
内科学 | 2468篇 |
皮肤病学 | 70篇 |
神经病学 | 623篇 |
特种医学 | 357篇 |
外科学 | 1323篇 |
综合类 | 24篇 |
预防医学 | 213篇 |
眼科学 | 113篇 |
药学 | 581篇 |
中国医学 | 11篇 |
肿瘤学 | 1006篇 |
出版年
2023年 | 65篇 |
2022年 | 129篇 |
2021年 | 201篇 |
2020年 | 111篇 |
2019年 | 146篇 |
2018年 | 188篇 |
2017年 | 166篇 |
2016年 | 177篇 |
2015年 | 218篇 |
2014年 | 241篇 |
2013年 | 328篇 |
2012年 | 502篇 |
2011年 | 594篇 |
2010年 | 343篇 |
2009年 | 310篇 |
2008年 | 514篇 |
2007年 | 557篇 |
2006年 | 545篇 |
2005年 | 523篇 |
2004年 | 537篇 |
2003年 | 546篇 |
2002年 | 484篇 |
2001年 | 115篇 |
2000年 | 93篇 |
1999年 | 113篇 |
1998年 | 103篇 |
1997年 | 94篇 |
1996年 | 62篇 |
1995年 | 64篇 |
1994年 | 52篇 |
1993年 | 60篇 |
1992年 | 78篇 |
1991年 | 69篇 |
1990年 | 71篇 |
1989年 | 55篇 |
1988年 | 63篇 |
1987年 | 40篇 |
1986年 | 35篇 |
1985年 | 47篇 |
1984年 | 31篇 |
1983年 | 30篇 |
1982年 | 22篇 |
1981年 | 20篇 |
1980年 | 21篇 |
1979年 | 20篇 |
1978年 | 30篇 |
1977年 | 13篇 |
1974年 | 12篇 |
1971年 | 9篇 |
1968年 | 7篇 |
排序方式: 共有8906条查询结果,搜索用时 15 毫秒
991.
Outcomes following pacemaker implantation after transcatheter aortic valve implantation with CoreValve® devices: Results from the FRANCE 2 Registry
下载免费PDF全文
![点击此处可从《Catheterization and cardiovascular interventions》网站下载免费的PDF全文](/ch/ext_images/free.gif)
992.
Ayako Kozuma Masanori Sasaki Katsuhiro Seki Takeshi Toyoshima Hiroyuki Nakano Yoshihide Mori 《Oral and maxillofacial surgery》2017,21(2):193-200
Objectives
Among intra/postoperative complications of sinus augmentation from a lateral approach, postoperative infection and implant loss are particularly important because they have irreversible consequences. The purpose of this study was to determine the causes of postoperative infection and implant loss after a lateral approach and to determine the appropriate prophylaxis and therapy.Materials and methods
In total, 109 patients (121 sinuses, 252 implants) were included in this study. The correlation between postoperative infection and implant loss and clinical variables was assessed using logistic regression analyses.Results
Postoperative infection and implant loss occurred in 8/121 sinuses (6.6%). Infection had the strongest correlation to preoperative chronic sinusitis (p = 0.007), followed by timing of implant insertion. Implant loss had the strongest correlation to preoperative chronic sinusitis (p = 0.007), followed by sex, diabetes, postoperative use of dentures, and intraoperative perforation of the sinus membrane.Conclusions
Preoperative chronic sinusitis could be a significant cause of postoperative infection and implant loss when using sinus augmentation from a lateral approach. For appropriate prophylaxis and therapy, it is necessary to diagnose the presence of chronic sinusitis that should be treated with proper methods prior to sinus augmentation.993.
Midori Nakamura Yuko Nakamichi Toshihide Mizoguchi Masanori Koide Teruhito Yamashita Toshiaki Ara Hiroshi Nakamura Josef M. Penninger Yuriko Furuya Hisataka Yasuda Nobuyuki Udagawa 《Journal of oral biosciences / JAOB, Japanese Association for Oral Biology》2017,59(3):146-151
Objective
A RANKL-binding peptide, WP9QY (W9), is known to inhibit mouse osteoclastogenesis by stimulating the production of autocrine factors such as bone morphogenetic proteins (BMPs) to induce osteoblast differentiation. In the present study, we investigated whether osteoblastic differentiation is mediated by RANKL signaling.Methods
The effect of W9 on the differentiation of osteoclasts and osteoblasts was examined in mouse bone-marrow cultures, and in a mouse co-culture system consisting of primary osteoblasts derived from RANKL-deficient or wild-type (WT) newborn mouse calvariae, with WT-derived bone marrow mononuclear cells.Results
The addition of the W9 peptide to the WT mouse bone-marrow culture simultaneously inhibited RANKL-induced tartrate-resistant acid phosphatase (TRAP)-positive osteoclast differentiation, and stimulated alkaline phosphatase (ALP)-positive osteoblastic calcified nodule formation. RANKL-deficient osteoblasts exhibited weak ALP activity compared to WT osteoblasts. W9 treatment strongly inhibited TRAP-positive osteoclast formation, and stimulated ALP-positive osteoblast differentiation in co-cultures of WT-derived osteoblasts and bone-marrow cells, in the presence of bone-resorbing factors. In contrast, W9 exerted only a weak effect on ALP-positive osteoblast differentiation in co-cultures with RANKL-deficient osteoblasts, even in the presence of the W9 peptide, parathyroid hormone, and/or BMP-2.Conclusions
The W9 peptide inhibited RANKL-mediated osteoclast formation in osteoblasts. It also directly stimulated osteoblast differentiation, both via RANKL signaling-mediated autocrine factors, and alternative mechanisms. 相似文献994.
Chronic Pelvic Ischemia: Contribution to the Pathogenesis of Lower Urinary Tract Symptoms (LUTS): A New Target for Pharmacological Treatment?
下载免费PDF全文
![点击此处可从《Lower urinary tract symptoms.》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The incidence of lower urinary tract symptoms, including overactive bladder (OAB), is continuing to rise, and is associated with a negative impact on quality of life and a heavy economic burden. A major risk factor for OAB is advancing age. The etiology of OAB is multifactorial and appears to involve myogenic, neurogenic, and urotheliogenic factors. In this article, we review the strengthening preclinical evidence supporting the contribution of chronic pelvic ischemia to the pathogenesis of OAB. In animal models, chronic ischemia induced by arterial injury and a high‐fat diet upregulates markers of oxidative stress and proinflammatory cytokines in the urothelium and lamina propria, and leads to increased expression of nerve growth factor. These processes result in increased afferent activity and an increased frequency of micturition, reflecting a state of bladder hyperactivity. In severe, prolonged cases, bladder overactivity may develop into underactivity. Antimuscarinic therapies are the mainstay of OAB treatment, but their usefulness is limited by modest efficacy and troublesome side‐effects. Our increasing understanding of the contribution of chronic ischemia to OAB is leading toward novel therapeutic options targeting chronic pelvic ischemia and its morphological, functional, and oxidative consequences. Preclinical trials have demonstrated encouraging results with α1‐adrenoreceptor blockade, phosphodiesterase type 5 inhibition, β3‐adrenoreceptor agonism, free radical scavenging, and stem cell therapy, in preventing morphological, biochemical and functional changes induced by chronic bladder ischemia. 相似文献
995.
996.
Toshiaki Arimura Masanori Abe Hidetoshi Shiga Hiroshi Katayama Kazo Kaizu Shigeto Oda 《Journal of artificial organs》2017,20(3):244-251
To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57.9%) was the most common mode of BPT, followed by intermittent renal replacement therapy (20.2%) and direct hemoperfusion with the polymyxin B-immobilized fiber column (PMX-DHP) (11.5%). Nafamostat mesilate (84.9%) was most frequently used as the anticoagulant. The 28-day survival rate was 56.8% in all patients. The most common mode for acute kidney injury (AKI) and multiple organ failure was CRRT, while PMX-DHP and CRRT were most common for sepsis. There was no significant difference in survival rates among AKI stages 1–3. Survival rate (38.3%) was significantly lower in patients with acute lung injury (ALI) than in those with multiple organ failure (41.8%) and those with sepsis (46.6%). Multivariate regression analysis revealed that the APACHE II score and the presence of acute ALI and acute hepatic failure were significantly associated with death. This large-scale cohort study showed the clinical status of BPT in Japan. Further investigations are required to clarify the efficacy of BPT for critically ill patients. 相似文献
997.
Satoshi Tsutsumi Ikuko Ogino Masakazu Miyajima Masanori Ito Hajime Arai Yukimasa Yasumoto 《Journal of anatomy》2015,227(3):297-301
The aim of this study was to quantitatively evaluate the function of the cranial diploic and spinal epidural veins as cerebrospinal fluid (CSF) drainage pathways by measuring lipocalin‐type prostaglandin D synthase (PGDS) and cystatin C (CysC) dissolved in the blood of these veins. This was a prospective study involving 51 consecutive patients, 31 males and 20 females, who underwent 41 cranial and 10 spinal surgeries. Intraoperatively, peripheral venous blood and diploic venous blood, or peripheral venous blood and spinal epidural venous blood samples were simultaneously collected and immediately centrifuged. For all samples, dissolved albumin (for reference), PGDS and CysC were measured using an enzyme‐linked immunosorbent assay. The diploic vein/peripheral vein ratios in five cranial locations and epidural vein/peripheral vein ratios were calculated and statistically evaluated for the three biomarkers. For PGDS, the diploic vein/peripheral vein ratio was significantly increased in the frontal (P = 0.011), temporal (P = 0.028), parietal (P = 0.046) and skull base (P = 0.039), while it did not reach statistical significance for CysC. For patients older than 45 years, the diploic vein/peripheral vein ratio for PGDS was significantly decreased in the frontal region (P = 0.028), and the epidural vein/peripheral vein ratio for CysC was significantly decreased (P = 0.014). These results show that the diploic veins constitute CSF drainage pathways with heterogeneous functional intensity at different cranial locations. Compared with the diploic veins, spinal epidural veins seem to drain less CSF. The cranial diploic and spinal epidural veins may jointly function as an alternative, age‐related trans‐dural CSF drainage system. 相似文献
998.
Vitamin D‐related gene polymorphisms do not influence the outcome and serum vitamin D level in pegylated interferon/ribavirin therapy combined with protease inhibitor for patients with genotype 1b chronic hepatitis C
下载免费PDF全文
![点击此处可从《Journal of medical virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
999.
1000.
Characterization of the native form and the carboxy‐terminally truncated halotolerant form of α‐amylases from Bacillus subtilis strain FP‐133
下载免费PDF全文
![点击此处可从《Journal of basic microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)