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991.
992.
993.
Shunji Shiohira Mizuki Komatsu Masayuki Okazaki Toshiaki Naganuma Hiroshi Kawaguchi Kosaku Nitta Ken Tsuchiya 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2016,20(1):20-26
Taurine, an important factor in the living body, is essential for cardiovascular function and development and function of skeletal muscle, retina and central nervous system. In the present study, its effect on cardiovascular function was specifically taken into consideration. In hemodiafiltration (HDF) patients, the effect of taurine on patients with chronic heart failure (CHF), in whom dry weight was difficult to control, was evaluated. All patients who were subjected to regular HDF for 4 h three times per week at Joban hospital were included in this study. Patients with chronic heart failure, in whom dry weight was difficult to control (N = 4), were included in the evaluation of clinical status. X‐ray and echocardiography were determined before and after taurine treatment. Almost all patients were taking nitric acid, warfarin, anti‐platelet agents and vasopressors. Because vital signs were unstable in chronic heart failure, all cases withheld antihypertensive drugs during HDF. For unstable vital signs during HDF, pulmonary congestion was chronically recognized. After taurine was started, vital signs stabilized and lowering of dry weight was possible. In addition, X‐ray and cardiac diastolic failure on echocardiography improved. Taurine was effective for CHF patients on HDF in whom dry weight was difficult to control in spite of various medications. 相似文献
994.
Role of 3‐D conformal radiotherapy for major portal vein tumor thrombosis combined with hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma 下载免费PDF全文
Hatsue Fujino Tomoki Kimura Hiroshi Aikata Daisuke Miyaki Tomokazu Kawaoka Hiromi Kan Takayuki Fukuhara Tomoki Kobayashi Noriaki Naeshiro Yohji Honda Masataka Tsuge Akira Hiramatsu Michio Imamura Yoshiiku Kawakami Hideyuki Hyogo Shoichi Takahashi Rika Yoshimatsu Takuji Yamagami Masahiro Kenjo Yasushi Nagata Kazuo Awai Kazuaki Chayama 《Hepatology research》2015,45(6):607-617
995.
Association Between Pulse Wave Velocity and a Marker of Renal Tubular Damage (N‐Acetyl‐β‐D‐Glucosaminidase) in Patients Without Diabetes 下载免费PDF全文
Motoshi Ouchi MD PhD Kenzo Oba MD PhD Taro Saigusa MD Kentaro Watanabe MD PhD Makoto Ohara MD PhD Noriaki Matsumura MD Tatsuya Suzuki MD PhD Naohiko Anzai MD PhD Shuichi Tsuruoka MD PhD Masahiro Yasutake MD PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2015,17(4):290-297
The authors assessed the association between the ratio of urinary activity of N‐acetyl‐β‐D‐glucosaminidase (NAG) to creatinine and the brachial‐ankle pulse wave velocity (baPWV) in patients without overt diabetes mellitus (DM). This was a cross‐sectional study of 233 patients who had an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2 and no history of kidney disease. Patients were divided into two groups: high NAG group (>5.8 U/g creatinine) and low NAG group (≤5.8 U/g creatinine). Mean baPWVs of the high NAG group were significantly higher than those of the low NAG group in both the eGFR ≥30 and <60 tertiles and the eGFR ≥60 and <90 tertiles. The baPWV was positively correlated with NAG in all patients (r=0.341, P<.001). Stepwise multivariate regression analysis showed that the baPWV was significantly related with NAG, age, and systolic blood pressure. Elevated NAG is related to elevated arterial stiffness in patients without DM. 相似文献
996.
Treatment of hepatic amyloid light‐chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient 下载免费PDF全文
Ryosuke Nakano Masahiro Ohira Kentaro Ide Kohei Ishiyama Tsuyoshi Kobayashi Hiroyuki Tahara Hirotaka Tashiro Yoshiaki Kuroda Tatsuo Ichinohe Koji Arihiro Kazuaki Chayama Hideki Ohdan 《Hepatology research》2015,45(10):E150-E155
Hepatic amyloid light‐chain (AL) amyloidosis is characterized by abnormal deposition of amyloid fibrils in the liver. As this precursor protein is produced by a proliferative plasma cell clone in the bone marrow, liver transplantation (LT) does not affect the disease's progression. Here, we describe the successful treatment using bortezomib‐ and dexamethasone‐based chemotherapy, following LT, of hepatic AL amyloidosis in a 65‐year‐old woman with progressive liver failure. The patient presented with progressive hepatic dysfunction accompanied by hepatorenal syndrome requiring hemodialysis, and living donor LT was successfully performed. Histology revealed amyloid deposits in the liver and stomach, and serum immunofixation revealed AL amyloidosis (κ‐type). The patient began chemotherapy on day 45 after the LT, and remission was achieved after one course. She was subsequently discharged 83 days after the LT, with normal liver and renal function, and no clinical evidence of recurrent disease was observed at the latest follow up (22 months post‐LT). 相似文献
997.
Masahiro To Yohei Kamata Juri Saruta Tomoko Shimizu Takenori Sato Yusuke Kondo Takashi Hayashi Nobushiro Hamada Keiichi Tsukinoki 《ACTA HISTOCHEMICA ET CYTOCHEMICA》2013,46(1):25-34
It is important to understand the onset of periodontal disease in terms of bacterial infection and host factors. Host-bacteria interactions can be elicited in human cultured cells and animal models, but these models provide only limited biological information about human host reactions against bacterial attacks. Development of an in vivo model using human gingival tissue is needed. We established an in vivo model using nu/nu mice and evaluated host defense following bacterial infection in human gingiva. Human gingival samples were collected from periodontitis patients and transplanted in nu/nu mouse subdermis. After 2 weeks, human characteristics were confirmed by positive immunohistochemical reactions for human-specific markers. We used this model to investigate human β-defensin-2 (hBD-2), an antimicrobial peptide that contributes to initial defense against bacterial invasion. Using real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry, we investigated whether hBD-2 expression was induced in human gingiva as a response to Porphyromonas gingivalis as a periodontal pathogen. Two hours after infection with bacteria, we detected increased expression of hBD-2 mRNA, which was localized in the epithelium of human gingiva. Using our in vivo model, we concluded that increased hBD-2 may play an important role in early defense from bacterial infection in human gingival epithelium. 相似文献
998.
Kazuyuki Furuta Mayuko Natsuhara Hirotsugu Takano Soken Tsuchiya Yasushi Okuno Hiroshi Ohtsu Masahiro Nishibori Robin L. Thurmond Noriyasu Hirasawa Kazuhisa Nakayama Atsushi Ichikawa Yukihiko Sugimoto Satoshi Tanaka 《European journal of immunology》2014,44(1):204-214
Mast cells are the major sources of histamine, which is released in response to immunological stimulations. The synthesis of histamine is catalyzed by histidine decarboxylase (HDC). Previous studies have shown that Hdc?/? mast cells exhibit aberrant granule morphology with severely decreased granule content. Here, we investigated whether the histamine synthesized in mast cells regulates the granule maturation of murine mast cells. Several genes, including those encoding granule proteases and enzymes involved in heparin biosynthesis, were downregulated in Hdc?/? peritoneal mast cells. Impaired granule maturation was also found in Hdc?/? BM‐derived cultured mast cells when they were cocultured with fibroblasts in the presence of c‐kit ligand. Exogenous application of histamine and several H4 receptor agonists restored the granule maturation of Hdc?/? cultured mast cells. However, the maturation of granules was largely normal in Hrh4?/? peritoneal mast cells. Depletion of cellular histamine with tetrabenazine, an inhibitor of vesicular monoamine transporter‐2, did not affect granule maturation. In vivo experiments with mast cell deficient KitW/KitW‐v mice indicated that the expression of the Hdc gene in mast cells is required for granule maturation. These results suggest that histamine promotes granule maturation in mast cells and acts as an proinflammatory mediator. 相似文献
999.
Beniyo Kawabuchi Yuichi Ishikawa Shigehiro Tsuchiya Ken Nakagawa Rikuo Machinami Eiju Tsuchiya 《Pathology international》1993,43(11):690-695
The first case of mucosal spreading adenocarcinoma at the hilum of the lung is presented. The patient was a 72 year old Japanese male smoker. The carcinoma was located at the right main bronchus with involvement of the apical, posterior and anterior segmental bronchi. The tumor consisted of stratified oval or polygonal cells and signet ring cells spreading along the bronchial mucosa in an in situ fashion with extension down the bronchial gland ducts and acini. Only a small micro-invasive focus not extending beyond the bronchial cartilage was seen. Immunohistochemically, the tumor was positive for lysozyme but negative for lactoferrin and PE-10 indicating that this tumor was possibly showing goblet cell differentiation. 相似文献
1000.
Taito Mahoko Taito Shunsuke Banno Masahiro Fujiwara Takashi Okamura Hitoshi Tsujimoto Hiraku Kataoka Yuki Tsujimoto Yasushi 《European archives of oto-rhino-laryngology》2019,276(6):1573-1583
European Archives of Oto-Rhino-Laryngology - We aimed to determine whether voice rehabilitation after radiotherapy improves the quality of life (QOL), voice function, and self-rated voice function... 相似文献