全文获取类型
收费全文 | 1275篇 |
免费 | 94篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 28篇 |
妇产科学 | 9篇 |
基础医学 | 199篇 |
口腔科学 | 35篇 |
临床医学 | 88篇 |
内科学 | 289篇 |
皮肤病学 | 46篇 |
神经病学 | 152篇 |
特种医学 | 31篇 |
外科学 | 171篇 |
综合类 | 7篇 |
预防医学 | 55篇 |
眼科学 | 23篇 |
药学 | 92篇 |
中国医学 | 1篇 |
肿瘤学 | 150篇 |
出版年
2024年 | 2篇 |
2023年 | 10篇 |
2022年 | 23篇 |
2021年 | 36篇 |
2020年 | 26篇 |
2019年 | 30篇 |
2018年 | 34篇 |
2017年 | 40篇 |
2016年 | 33篇 |
2015年 | 47篇 |
2014年 | 52篇 |
2013年 | 70篇 |
2012年 | 106篇 |
2011年 | 85篇 |
2010年 | 63篇 |
2009年 | 57篇 |
2008年 | 101篇 |
2007年 | 89篇 |
2006年 | 83篇 |
2005年 | 82篇 |
2004年 | 97篇 |
2003年 | 64篇 |
2002年 | 56篇 |
2001年 | 11篇 |
2000年 | 13篇 |
1999年 | 12篇 |
1998年 | 8篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 6篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1978年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有1378条查询结果,搜索用时 15 毫秒
41.
Andrea Corbingi Idanna Innocenti Annamaria Tomasso Raffaella Pasquale Andrea Visentin Marzia Varettoni Elena Flospergher Francesco Autore Francesca Morelli Livio Trentin Gianluigi Reda Dimitar G. Efremov Luca Laurenti 《British journal of haematology》2020,190(6):901-908
The relationship between chronic lymphocytic leukaemia (CLL) and qualitative/quantitative gammaglobulin abnormalities is well established. Nevertheless, in order to better understand this kind of connection, we examined 1505 patients with CLL and divided them into four subgroups on the basis of immunoglobulin (Ig) aberrations at diagnosis. A total of 73 (4·8%), 149 (10%), 200 (13·2%) and 1083 (72%) patients were identified with IgM monoclonal gammopathy (IgM/CLL), IgG monoclonal gammopathy (IgG/CLL), hypogammaglobulinaemia (hypo-γ) and normal Ig levels (γ-normal) respectively. IgM paraprotein was significantly associated with a more advanced Binet/Rai stage and del(17p)/TP53 mutation, while IgG abnormalities correlated with a higher occurrence of trisomy 12. Patients with any type of Ig abnormality had shorter treatment-free survival (TFS) but no significant impact affecting overall survival (OS) compared to those with normal Ig levels. 相似文献
42.
Marco Cerrano Massimiliano Bonifacio Matteo Olivi Antonio Curti Michele Malagola Michelina Dargenio Anna Maria Scattolin Cristina Papayannidis Fabio Forghieri Carmela Gurrieri Ilaria Tanasi Patrizia Zappasodi Roberta La Starza Nicola Stefano Fracchiolla Patrizia Chiusolo Luisa Giaccone Maria Ilaria Del Principe Fabio Giglio Marzia Defina Claudio Favre Carmelo Rizzari Barbara Castella Giovanni Pizzolo Felicetto Ferrara Sabina Chiaretti Robin Fo 《Haematologica》2022,107(4):996
43.
Adapted physical exercise enhances activation and differentiation potential of satellite cells in the skeletal muscle of old mice 下载免费PDF全文
Barbara Cisterna Marzia Giagnacovo Manuela Costanzo Patrizia Fattoretti Carlo Zancanaro Carlo Pellicciari Manuela Malatesta 《Journal of anatomy》2016,228(5):771-783
During ageing, a progressive loss of skeletal muscle mass and a decrease in muscle strength and endurance take place, in the condition termed sarcopenia. The mechanisms of sarcopenia are complex and still unclear; however, it is known that muscle atrophy is associated with a decline in the number and/or efficiency of satellite cells, the main contributors to muscle regeneration. Physical exercise proved beneficial in sarcopenia; however, knowledge of the effect of adapted physical exercise on the myogenic properties of satellite cells in aged muscles is limited. In this study the amount and activation state of satellite cells as well as their proliferation and differentiation potential were assessed in situ by morphology, morphometry and immunocytochemistry at light and transmission electron microscopy on 28‐month‐old mice submitted to adapted aerobic physical exercise on a treadmill. Sedentary age‐matched mice served as controls, and sedentary adult mice were used as a reference for an unperturbed control at an age when the capability of muscle regeneration is still high. The effect of physical exercise in aged muscles was further analysed by comparing the myogenic potential of satellite cells isolated from old running and old sedentary mice using an in vitro system that allows observation of the differentiation process under controlled experimental conditions. The results of this ex vivo and in vitro study demonstrated that adapted physical exercise increases the number and activation of satellite cells as well as their capability to differentiate into structurally and functionally correct myotubes (even though the age‐related impairment in myotube formation is not fully reversed): this evidence further supports adapted physical exercise as a powerful, non‐pharmacological approach to counteract sarcopenia and the age‐related deterioration of satellite cell capabilities even at very advanced age. 相似文献
44.
Andrea Chiricozzi Nicola Pimpinelli Federica Ricceri Giovanni Bagnoni Laura Bartoli Mauro Bellini Luca Brandini Marzia Caproni Antonio Castelli Michele Fimiani Franco Marsili Carlo Mazzatenta Maria Chiara Niccoli Salvatore Panduri Michele Pellegrino Riccardo Sirna Walter Volpi Marco Romanelli Francesca Prignano 《Dermatologic therapy》2017,30(6)
Psoriasis is a chronic and relapsing inflammatory skin disease, clinically characterized by erythematous and scaly plaques. Treatment approach is mainly driven by disease severity, though several factors should be considered in order to identify the optimal therapeutic choice. Mild psoriasis may be treated with a wide array of topical agents including corticosteroids, vitamin D analogs, keratolytics, and calcipotriol/betamethasone propionate compound. Because guidelines may not provide practical indications regarding the therapeutic approach, the use of topical agents in psoriasis is more individually tailored. In order to homogenize the standard of care, at least in a local setting, we collected the real‐life‐based recommendations for the use of topical therapies from an expert panel, the Tuscany Consensus Group on Psoriasis, representing all leading centers for psoriasis established in Tuscany. With this document, this consensus group sought to define principles guiding the selection of therapeutic agents with straightforward recommendations derived from a real‐life setting. 相似文献
45.
Vincenzo Solfrizzi Emanuele Scafato Madia Lozupone Davide Seripa Michele Giannini Rodolfo Sardone Caterina Bonfiglio Daniela I. Abbrescia Lucia Galluzzo Claudia Gandin Marzia Baldereschi Antonio Di Carlo Domenico Inzitari Antonio Daniele Carlo Sabbà Giancarlo Logroscino Francesco Panza 《The American journal of geriatric psychiatry》2017,25(11):1236-1248
46.
47.
Alberto Lerario Filippo Cogiamanian Chiara Marchesi Marzia Belicchi Nereo Bresolin Laura Porretti Yvan Torrente 《BMC musculoskeletal disorders》2010,11(1):157
Background
The administration of rituximab (RTX) in vivo results in B-cell depletion, but evidence for multiple mechanisms of action have been reported. Surprisingly, B cell depletion produced a response in patients with polymyositis, which is characterized as a T cell-mediated autoimmune disorder with biopsy findings similar to Miyoshi myopathy (MM). Indeed, in dysferlinopathies, there is evidence of immune system involvement including the presence of muscle inflammation and a down regulation of the complement inhibitory factor, CD55. 相似文献48.
Benedetto Falsini Dario Marangoni Tommaso Salgarello Giovanna Stifano Lucrezia Montrone Francesca Campagna Stefania Aliberti Emilio Balestrazzi Alberto Colotto 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2008,246(8):1153-1162
BACKGROUND: Pattern electroretinogram (PERG) and optical coherence tomography (OCT) represent objective probes to investigate respectively the function of retinal ganglion cells and their structure as retinal nerve fiber layer (RNFL) thickness. We examined interindividual (II) correlations of PERG amplitude and RNFL thickness, as well as correlations between interocular (IO) differences in both measures, in ocular hypertension (OHT) and early glaucoma (EG) patients. METHODS: Thirty-one OHT, 34 EG (mean deviation: -1 to -6 dB) and 16 age-matched controls were examined in both eyes. Participants had clear optical media, no or moderate refractive errors and no concomitant ocular or systemic diseases. PERGs were elicited by counterphased (16.28 reversals/second) gratings (1.6 cycles/degree spatial frequency). The Fourier isolated 2nd harmonic PERG amplitude and phase were measured. RNFL thickness was quantified by means of OCT Stratus according to a standard protocol. Average, superior and inferior RNFL thicknesses were considered. RESULTS: Mean PERG amplitude was decreased (p < 0.01) in both OHT and EG patients compared to controls. Mean RNFL thicknesses were reduced (p < 0.01) in EG patients compared to both OHT and controls. In OHT patients, PERG amplitude did not correlate significantly with RNFL thickness in both II and IO analysis. In EG patients, PERG amplitude was positively correlated with RNFL thickness in both II (p < 0.005) and IO (p < 0.001) analysis. The slope of the correlation predicted that PERG losses exceeded systematically RNFL losses when the latter were between 0 and -0.25 log units. CONCLUSIONS: Both II and IO analyses revealed a lack of structure-function relationship in OHT, suggesting that, at this disease stage, PERG losses appear to affect primarily retinal/optic nerve head function. In EG they reflect both dysfunction and RNFL loss. 相似文献
49.
A personal technique: mammaplasty with J scar 总被引:2,自引:0,他引:2
Mastopexy and reduction mammaplasty techniques have evolved with time, pursuing the aim of an effective and reliable technique that produces a well-shaped breast and reduces the amount of scarring. The authors believe that the L mammaplasty achieves the best results in terms of a short scar and a good, stable shape. They present their technique of a modified L mammaplasty with a resulting scar in the shape of a J, which implies a central breast resection with the nipple-areola complex transposed on a superior pedicle. The correct execution of the preoperative markings and the shaping of the gland tissue are mandatory to obtaining the desired result. The technique has been used during the past 7 years on 326 patients, providing satisfactory results with short scars and virtually no complications. 相似文献
50.
Torrente Y Belicchi M Pisati F Pagano SF Fortunato F Sironi M D'Angelo MG Parati EA Scarlato G Bresolin N 《Cell transplantation》2002,11(1):25-34
Stem cell populations have been shown to be extremely versatile: they can generate differentiated cells specific to the tissue in which they reside and descendents that are of different germ layer origin. This raises the possibility of obtaining neuronal cells from new biological source of the same adult human subjects. In this study, we found that epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) cooperated to induce the proliferation, self-renewal, and expansion of neural stem cell-like population isolated from several newborn and adult mouse tissues: muscle and hematopoietic tissues. This population, in both primary culture and secondary expanded clones, formed spheres of undifferentiated cells that were induced to differentiate into neurons, astrocytes, and oligodendrocytes. Brain engraftment of the somatic-derived neural stem cells generated neuronal phenotypes, demonstrating the great plasticity of these cells with potential clinical application. 相似文献