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排序方式: 共有1481条查询结果,搜索用时 15 毫秒
81.
Mohamed Marwan Tobias Pflederer Dieter Ropers Michael Schmid Gerald Wasmeier Stephan Söder Werner G. Daniel Stephan Achenbach 《Journal of Cardiovascular Computed Tomography》2008,2(6):403-405
The ability of contrast-enhanced CT to detect “late enhancement” in a fashion similar to magnetic resonance imaging has been reported previously. Typical myocardial distribution patterns of “late enhancement” have been described for MRI. The same patterns can be observed in CT imaging, albeit at a lower signal to noise ratio. We report a case of cardiac amyloidosis with a typical pattern of subendocardial, circumferential late enhancement in all four cardiac chambers. 相似文献
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A 15-year-old white woman, karyotype 46,XX, had an absent vagina and uterus (Rokitansky-Kuster-Hauser syndrome) as well as an atrial septal defect and transphalangeal thumb (Holt-Oram syndrome). The concurrence of the above two syndromes has not been reported on before. 相似文献
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Elena Moro Andres M. Lozano Pierre Pollak Yves Agid Stig Rehncrona Jens Volkmann Jaime Kulisevsky Jose A. Obeso Alberto Albanese Marwan I. Hariz Niall P. Quinn Jans D. Speelman Alim L. Benabid Valerie Fraix Alexandre Mendes Marie‐Laure Welter Jean‐Luc Houeto Philippe Cornu Didier Dormont Annalena L. Tornqvist Ron Ekberg Alfons Schnitzler Lars Timmermann Lars Wojtecki Andres Gironell Maria C. Rodriguez‐Oroz Jorge Guridi Anna R. Bentivoglio Maria F. Contarino Luigi Romito Massimo Scerrati Marc Janssens Anthony E. Lang 《Movement disorders》2010,25(5):578-586
We report the 5 to 6 year follow‐up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty‐five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross‐over double‐blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off‐ and on‐medication states with and without stimulation, activities of daily living (ADL), anti‐PD medications, and dyskinesias. In double‐blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off‐stimulation, regardless of the sequence of stimulation. In open assessment, both STN‐ and GPi‐DBS significantly improved the off‐medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti‐PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long‐term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN‐DBS patients and fewer adverse events in the GPi‐DBS group. © 2010 Movement Disorder Society 相似文献
87.
Gilles de la Tourette Syndrome (GTS) is characterized by multiple motor and one or more vocal/phonic tics. Psychopathology and co-morbidity occur in approximately 80-90% of clinical cohorts. The most common psychopathologies are attention deficit hyperactivity disorder, obsessive-compulsive behaviours, obsessive-compulsive disorder, depression, anxiety and certain behavioural disorders. In severe GTS patients who are refractory to medication and other therapies, deep brain stimulation (DBS) is investigated. To date there have been some 50-55 patients who have received DBS in 19 centres worldwide. Nine different brain targets in the thalamus, the pallidum, and the ventral caudate and anterior internal capsule have been stimulated. This paper reviews critically and in detail all studies published to date. Only two studies on just a few patients fulfil some of the evidence-based criteria. DBS for GTS is therefore still highly experimental. 相似文献
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The occurrence of tension pneumocephalus following ventriculoperitoneal (VP) shunt insertion is extremely rare, and is usually of delayed onset. We report a patient who developed an acute subdural tension pneumocephalus within 1 day following placement of a VP shunt for normal pressure hydrocephalus as a complication from shunt surgery. 相似文献
89.
Beach TG Sue LI Walker DG Lue LF Connor DJ Caviness JN Sabbagh MN Adler CH 《Acta neuropathologica》2007,114(4):419-424
Multiple reports have documented an age-related loss, estimated at about 10% per decade, of the pigmented neurons in the substantia
nigra. This is associated with motor dysfunction, including bradykinesia, stooped posture and gait disturbance. As microglia
are activated by cell death and neuromelanin pigment, we hypothesized that there should be a significant microglial reaction
in normal aging human substantia nigra. Sections of substantia nigra from elderly subjects (N = 15; mean 81.3; SD 7.0) and younger subjects (N = 7; mean 30.3; SD = 8.7), all of which had no specific neurologically or neuropathologically defined disorders, were stained
immunohistochemically for MHC Class II and the area occupied by microglia was quantified in substantia nigra pars compacta.
All elderly subjects showed a pronounced microglial reaction in the substantia nigra, with frequent, intensely stained hypertrophic
microglia, while immunoreactive nigral microglia were much less frequent in the younger subjects. Quantification showed that
in older subjects, the percentage of substantia nigra area occupied by microglial bodies and processes was significantly greater
than for younger subjects (mean 19.6 vs. 3.6; P = 0.005). Extraneuronal neuromelanin deposits were present in all the older subjects but were absent or rare in the younger
subjects. The neuromelanin deposit abundance score in the older subjects correlated significantly with the area occupied by
immunoreactive microglia. The marked microglial reaction in normal aging human substantia nigra, together with the previously
reported 35–80% pigmented neuron loss, indicates the presence of a powerful pathologic process that may be additive with specific
age-related neurodegenerative diseases, including Parkinson’s disease. 相似文献
90.
Aström M Zrinzo LU Tisch S Tripoliti E Hariz MI Wårdell K 《Medical & biological engineering & computing》2009,47(1):21-28
Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease. Success of DBS is highly dependent on electrode
location and electrical parameter settings. The aim of this study was to develop a general method for setting up patient-specific
3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such models for assessing the
position of the electrode contacts and the distribution of the electric field in relation to individual patient anatomy. A
software tool was developed for creating finite element DBS-models. The electric field generated by DBS was simulated in one
patient and the result was visualized with isolevels and glyphs. The result was evaluated and it corresponded well with reported
effects and side effects of stimulation. It was demonstrated that patient-specific finite element models and simulations of
DBS can be useful for increasing the understanding of the clinical outcome of DBS. 相似文献