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961.
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963.
The aim of our research was to study if cholesterol feeding might affect the ischemic changes in the vessels surrounding infarction foci in Sephadex G-75-induced cerebral ischemia model (SG-75). One hundred-twenty-four rabbits were divided as follows: group I was given standard food for 5 weeks; group II: as group I and then injected with SG-75; group III: standard food plus 1% cholesterol for 5 weeks; and group IV: as group III and then injected with SG-75. Rabbits were sacrificed 3 h, 6 h and 2, 5 and 7 days after ischemia had occurred. Vessels surrounding infarction foci (SIF) were identified by using a 6% carbon perfusion. Samples were examined by light microscopy and transmission electron microscopy (TEM). The occurrence of hemorrhagic infarction (HI) showed a clear time/course increase in group II whereas a decrease after 2 days in group IV was observed. The rate of HI was 40% and 20% in group II and IV, respectively. SIF vessels showed red blood cells leakage in group II, whereas multiple platelet thrombi appeared in group IV. This phenomenon caused a more extensive ischemic damage, when compared to group II. By making use of a widely employed model of high cholesterol diet and of a more physiological model of cerebral ischemia devised by us, we have provided the evidence that the hypercholesterolemia-induced changes in the SIF vessels strongly affect the pattern and progression of cerebral ischemia. 相似文献
964.
Outpatient percutaneous nephrostomy 总被引:1,自引:0,他引:1
965.
966.
967.
Recurrent mutations in a single exon encoding the evolutionarily conserved olfactomedin-homology domain of TIGR in familial open-angle glaucoma 总被引:13,自引:3,他引:10
Adam MF; Belmouden A; Binisti P; Brezin AP; Valtot F; Bechetoille A; Dascotte JC; Copin B; Gomez L; Chaventre A; Bach JF; Garchon HJ 《Human molecular genetics》1997,6(12):2091-2097
Primary open-angle glaucoma (POAG) is a highly prevalent cause of
irreversible blindness which associates cupping of the optic disc and
alteration of the visual field, elevation of intraocular pressure being a
major risk factor. Provided diagnosis is made at an early stage, treatments
are available to prevent visual impairment. A locus, GLC1A, has been mapped
on chromosome 1q23-q25 in several families affected with juvenile-onset
POAG (JOAG) and also in some families affected with juvenile and middle-age
onset POAG. Recently, three mutations of the TIGR (Trabecular
meshwork-Induced Glucocorticoid Response) gene were shown to be responsible
for the disease in several American families and in unrelated POAG
patients. We now describe five new mutations in eight French families. All
mutations known to date appear to concentrate in the evolutionarily
conserved C-terminal domain of TIGR which bears homology to frog
olfactomedin, an extracellular matrix glycoprotein of the olfactory
epithelium, to rat and human neuronal olfactomedin-related proteins and to
F11C3.2, a protein from Caenorhabditis elegans . Moreover, this conserved
domain of TIGR is encoded by a single exon to which mutation screening
could be limited. Surprisingly, the TIGR message, which is abundantly
transcribed in the trabecular meshwork and also in the ciliary body and the
sclera, is not expressed in the optic nerve whose degeneration is, however,
the primary lesion of POAG.
相似文献
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969.
F Marotta H Tajiri M Yoshimori K Nakamura H Ozaki 《The Italian journal of gastroenterology》1991,23(4):197-201
A nine year retrospective survey was carried out at the National Cancer Center Hospital in order to define the diagnostic clues and most suitable diagnostic assessment in resectable pancreatic cancer patients. Forty six cases were detected (27 pancreatic head cancers, 19 pancreatic body and tail cancers). There were 8, 26, 3 and 9 cases of t1, t2, t3 and t4 tumour size cancers, respectively. Abdominal pain and/or discomfort and back pain were the most common initial symptoms and chief complaints. Jaundice was present only in pancreatic head cancer cases. Abnormal GTT and CA 19-9 were the biochemical tests most commonly found abnormal, irrespective of tumour size. ERCP followed by US and CT were the most accurate technical tests. The best care toward the awareness of the initial symptoms needs to be followed, as a first choice, by a proper biochemical (CA 19-9, GTT) and technical (US, ERCP, CT) assessment in the hope of identifying those patients whose prognosis might be improved by an early operation. 相似文献
970.