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Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and tics. 总被引:6,自引:0,他引:6
Tanya K Murphy Muhammad Sajid Ohel Soto Nathan Shapira Paula Edge Mark Yang Mark H Lewis Wayne K Goodman 《Neuropsychopharmacology》2004,55(1):61-68
BACKGROUND: A subgroup of children with obsessive-compulsive and tic disorders are proposed to have an infectious trigger. The purpose of this study was to investigate the relationship between group A streptococcal titers and symptom fluctuations in children with a clinical course resembling that described for pediatric autoimmune neuropsychiatric disorders associated with streptococcus. METHODS: Twenty-five children with obsessive-compulsive disorder and/or tic disorder were evaluated for neuropsychiatric severity and group A streptococcal antibody titers (streptolysin O, deoxyribonuclease B, and carbohydrate A) at 6-week intervals for > or = six consecutive evaluations (total visits=277). RESULTS: Children with large symptom fluctuations (n=15) were compared with children without dramatic fluctuations (n=10). Co-movements of obsessive-compulsive/tic severity and group A streptococcal antibodies were assessed. In subjects with large symptom changes, positive correlations were found between streptococcal titers and obsessive-compulsive severity rating changes (p=.0130). These subjects were also more likely to have elevated group A streptococcal titers during the majority of observations (p=.001). Tic symptom exacerbations occurred more often in the fall/winter months than spring/summer months (p=.03). CONCLUSIONS: Patients with marked obsessive-compulsive/tic symptom changes may be characterized by streptococcal titer elevations and exhibit evidence of seasonal tic exacerbations. 相似文献
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Kunsook Song Bernstein 《Medsurg nursing》2006,15(6):333-341
Major depressive disorder is a psychiatric disorder that encompasses a broad range of emotional, psychological, behavioral, and physical symptoms (Fava et al., 2004). The nurse in the hospital, office, school, or community setting can provide the essential elements of effective care for depression, including early detection by screening, medication teaching, depression education, teaching coping skills, and appropriate use of specialists and resources. Utilizing the nursing process, the nurse can provide comprehensive care to improve the depressed patient's physical and psychological well-being. 相似文献
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Robert C. Eberhart Mark S. Munro Geraldine B. Williams Padmakar V. Kulkarni W. Allen Shannon Jr. † Bruce E. Brink William J. Fry 《Artificial organs》1987,11(5):375-382
The short-term albumin affinity and thrombo-resistance of a polyether polyurethane vascular graft have been improved. The method is based on the C18 alkylation of the polymer. Thrombus formation by a planimetric technique and albumin retention on wire-reinforced polyurethane tubes, both C18 alkylated and untreated, were measured in short-term (4-h) exposure at femoral arterial sites in the dog. 125I-Albumin was preabsorbed on tubes and then exposed to blood for successive 2-h periods. Albumin uptake on alkylated tubes prior to blood exposure and retention following 2 h of blood exposure were significantly greater than on controls. Following a fast desorption phase in blood, the remaining albumin was more slowly desorbed from alkylated than from control tubes. Reincubation with albumin and blood reexposure produced a similar tendency, suggesting blood conditioning does not reduce the albumin affinity-enhancing property of C18 alkylation in the short term. Blood-preconditioning experiments suggested endogenous albumin has a high affinity for the C18-alkylated surface. Scanning electron microscopic examination showed thrombus and platelet densities were higher on control than on alkylated surfaces. These results suggest in vivo albumin affinity is increased for C18-alkylated polyurethane, which may be linked to decreased thrombus formation on these surfaces. 相似文献
120.
George K Kouvidis Mark B Sommers Peter V Giannoudis Pavlos G Katonis Michael Bottlang 《Journal of orthopaedic surgery and research》2009,4(1):16-9