全文获取类型
收费全文 | 2600篇 |
免费 | 190篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 75篇 |
妇产科学 | 75篇 |
基础医学 | 335篇 |
口腔科学 | 46篇 |
临床医学 | 234篇 |
内科学 | 678篇 |
皮肤病学 | 36篇 |
神经病学 | 368篇 |
特种医学 | 55篇 |
外科学 | 193篇 |
综合类 | 7篇 |
预防医学 | 254篇 |
眼科学 | 12篇 |
药学 | 182篇 |
中国医学 | 3篇 |
肿瘤学 | 243篇 |
出版年
2024年 | 7篇 |
2023年 | 50篇 |
2022年 | 95篇 |
2021年 | 140篇 |
2020年 | 71篇 |
2019年 | 89篇 |
2018年 | 103篇 |
2017年 | 87篇 |
2016年 | 98篇 |
2015年 | 118篇 |
2014年 | 131篇 |
2013年 | 142篇 |
2012年 | 243篇 |
2011年 | 231篇 |
2010年 | 99篇 |
2009年 | 108篇 |
2008年 | 175篇 |
2007年 | 172篇 |
2006年 | 143篇 |
2005年 | 137篇 |
2004年 | 97篇 |
2003年 | 103篇 |
2002年 | 79篇 |
2001年 | 12篇 |
2000年 | 3篇 |
1999年 | 13篇 |
1998年 | 12篇 |
1997年 | 9篇 |
1996年 | 12篇 |
1995年 | 9篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1987年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1973年 | 4篇 |
1972年 | 1篇 |
1970年 | 1篇 |
1967年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有2817条查询结果,搜索用时 0 毫秒
11.
Human telomerase reverse transcriptase gene expression and the surgical management of suspicious thyroid tumors. 总被引:4,自引:0,他引:4
12.
13.
Luigi Quintieri Cristina Geroni Marianna Fantin Rosangela Battaglia Antonio Rosato William Speed Paola Zanovello Maura Floreani 《Clinical cancer research》2005,11(4):1608-1617
PURPOSE: Nemorubicin (3'-deamino-3'-[2'(S)-methoxy-4'-morpholinyl]doxorubicin; MMDX) is an investigational drug currently in phase II/III clinical testing in hepatocellular carcinoma. A bioactivation product of MMDX, 3'-deamino-3',4'-anhydro-[2'(S)-methoxy-3'(R)-oxy-4'-morpholinyl]doxorubicin (PNU-159682), has been recently identified in an incubate of the drug with NADPH-supplemented rat liver microsomes. The aims of this study were to obtain information about MMDX biotransformation to PNU-159682 in humans, and to explore the antitumor activity of PNU-159682. EXPERIMENTAL DESIGN: Human liver microsomes (HLM) and microsomes from genetically engineered cell lines expressing individual human cytochrome P450s (CYP) were used to study MMDX biotransformation. We also examined the cytotoxicity and antitumor activity of PNU-159682 using a panel of in vitro-cultured human tumor cell lines and tumor-bearing mice, respectively. RESULTS: HLMs converted MMDX to a major metabolite, whose retention time in liquid chromatography and ion fragmentation in tandem mass spectrometry were identical to those of synthetic PNU-159682. In a bank of HLMs from 10 donors, rates of PNU-159682 formation correlated significantly with three distinct CYP3A-mediated activities. Troleandomycin and ketoconazole, both inhibitors of CYP3A, markedly reduced PNU-159682 formation by HLMs; the reaction was also concentration-dependently inhibited by a monoclonal antibody to CYP3A4/5. Of the 10 cDNA-expressed CYPs examined, only CYP3A4 formed PNU-159682. In addition, PNU-159682 was remarkably more cytotoxic than MMDX and doxorubicin in vitro, and was effective in the two in vivo tumor models tested, i.e., disseminated murine L1210 leukemia and MX-1 human mammary carcinoma xenografts. CONCLUSIONS: CYP3A4, the major CYP in human liver, converts MMDX to a more cytotoxic metabolite, PNU-159682, which retains antitumor activity in vivo. 相似文献
14.
Hicham Dalloul Tobias Hainzl Anna Monori-Kiss Leila Hadjadj Gyrgy L. Ndasy Marianna Trk Szabolcs Vrbír 《Nutrients》2022,14(10)
The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery system. Male Wistar rats were divided into vitamin-D-deficient (VD−, n = 10) and vitamin-D-supplemented (VD+, n = 8) groups. After eight weeks, branches and segments of the left-anterior-descending-coronary-artery (LAD) network were analyzed by a video-microscopy technique. Segments were divided into 50 μm-long cylindrical ring units. VDD did not increase the number of morphological abnormalities. The number of segments did not differ between the groups (VD−: 210 and VD+: 224; pooled data of 8 networks). A larger lumen area of branches was found in VD+ group, while 1–4-order branches were lengthier in the VD− group. VD− rats had less rich coronary-resistance-artery networks in terms of 50 µm-long units. (VD−: 6365 vs. VD+: 6602; pooled data of 8 networks). VD+ animals were richer in the 100–350 µm outer diameter range, and VD− animals were richer in the 400–550 µm-diameter units. In VD− rats, 150–200 and 300 µm units were almost missing at higher flow distances from the orifice. Serum vitamin-D alterations caused by dietary changes can affect the geometry of the coronary-artery network, which may contribute to vitamin-D-dependent changes in cardiovascular mortality. 相似文献
15.
Teresa Perillo Alessio Vitiello Marianna Perrotta Antonietta Serino Andrea Manto 《Radiology Case Reports》2022,17(10):3678
We report a case of a 54-year-old man suffering from sciatalgia unresponsive to medical treatment. Imaging revealed a discal cyst the level L3-L4, a rare cause of low back pain, which has characteristic imaging features. In particular, on Magnetic Resonance Imaging it appears as a cystic formation with fluid content, which usually arises from the posterior contour of the intervertebral disc and it frequently has air bubbles within it. The patient underwent surgical treatment with resolution of symptoms. 相似文献
16.
17.
18.
Marijn de Bruin Jonathan E Suk Marianna Baggio Sarah Earnshaw Blomquist María Falcon Maria Joo Forjaz Karina Godoy-Ramirez Mariken Leurs Carmen Rodriguez-Blazquez María Romay-Barja Ellen Uiters John Kinsman 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(18)
Behavioural sciences have complemented medical and epidemiological sciences in the response to the SARS-CoV-2 pandemic. As vaccination uptake continues to increase across the EU/EEA – including booster vaccinations – behavioural science research remains important for both pandemic policy, planning of services and communication. From a behavioural perspective, the following three areas are key as the pandemic progresses: (i) attaining and maintaining high levels of vaccination including booster doses across all groups in society, including socially vulnerable populations, (ii) informing sustainable pandemic policies and ensuring adherence to basic prevention measures to protect the most vulnerable population, and (iii) facilitating population preparedness and willingness to support and adhere to the reimposition of restrictions locally or regionally whenever outbreaks may occur. Based on mixed-methods research, expert consultations, and engagement with communities, behavioural data and interventions can thus be important to prevent and effectively respond to local or regional outbreaks, and to minimise socioeconomic and health disparities. In this Perspective, we briefly outline these topics from a European viewpoint, while recognising the importance of considering the specific context in individual countries. 相似文献
19.
Background
Laparoscopic Roux-en-Y gastric bypass (LRYGB) is currently the gold standard bariatric procedure for the treatment of morbid obesity. Laparoscopic sleeve gastrectomy (LSG) is a relatively innovative procedure which has been increasingly applied lately as a sole bariatric procedure. A randomized trial was conducted in a Greek population to evaluate perioperative safety and 3-years results. 相似文献20.
Jane Cleary Shelly Casey Clare Hofsteede Robert G. Moses Marianna Milosavljevic Jennie Brand-Miller 《Nutrients》2012,4(11):1759-1766
The aim of this study was to examine the monetary cost of dietary change among pregnant women before and after receiving low glycaemic index (GI) dietary advice. The pregnant women in this study were a subgroup of participants in the Pregnancy and Glycaemic Index Outcomes (PREGGIO) study. Twenty women from the low GI dietary advice group, who had completed their pregnancies, were randomly chosen. All these women had completed three day food records at 12–16 weeks and again around 36 weeks of gestation. Consumer food prices were applied to recorded dietary intake data. The mean ± SD GI of the diet reduced from 55.1 ± 4.3 to 51.6 ± 3.9 (p = 0.003). The daily cost of the diet (AUD) was 9.1 ± 2.7 at enrolment and 9.5 ± 2.1 prior to delivery was not significantly different (p = 0.52). There were also no significant differences in the daily energy intake (p = 0.2) or the daily cost per MJ (p = 0.16). Women were able to follow low GI dietary advice during pregnancy with no significant increase in the daily costs. 相似文献