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排序方式: 共有356条查询结果,搜索用时 15 毫秒
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David N. Louis Pieter Wesseling Kenneth Aldape Daniel J. Brat David Capper Ian A. Cree Charles Eberhart Dominique Figarella‐Branger Maryam Fouladi Gregory N. Fuller Caterina Giannini Christine Haberler Cynthia Hawkins Takashi Komori Johan M. Kros HK Ng Brent A. Orr Sung‐Hye Park Werner Paulus Arie Perry Torsten Pietsch Guido Reifenberger Marc Rosenblum Brian Rous Felix Sahm Chitra Sarkar David A. Solomon Uri Tabori Martin J. van den Bent Andreas von Deimling Michael Weller Valerie A. White David W. Ellison 《Brain pathology (Zurich, Switzerland)》2020,30(4):844-856
cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT‐NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles—relating to classification categories, approaches to classification, nomenclature, and grading—that the group hopes will also inform the future classification of CNS neoplasms. 相似文献
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E Pesonen J Viikari L Räsänen T Moilanen J Turtinen HK Åkerblom 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(4):378-382
In the Finnish multicentre study of cardiovascular risk in young Finns in 1980, 1983 and 1986, 2429, 2052 and 1841 9 to 18-year-old children and adolescents participated. In 1980, subjects of eastern origin living in the west had, despite their western diet, higher serum cholesterol concentrations than subjects both residing in and originating from the west. In males, eastern origin increased the eastlwest difference in serum cholesterol concentrations. Between 1980 and 1986 the mean serum total cholesterol of the study cohorts decreased by 5.5% and simultaneously the east/west differences in serum cholesterol concentrations disappeared in boys. The study suggests that genetic background is a separate factor determining serum total cholesterol level, but with declining serum cholesterol concentrations the effect of the genetic factor does not become manifest. 相似文献
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目的 :比较不同文化背景的精神专科医生在评估多动症儿童各种症状表现时的一致程度 ,探讨文化对儿童多动症诊断可能产生的影响。方法 :使用单独或集体行为观察清单 ,让两地的精神科医生对儿童多动症的各种表现进行症状评估 ;所有的评估者均观察同一录像带上患儿的行为表现 ;对其评定结果进行统计和比较。结果 :儿童独自活动观察量表的 12项中有 11项症状条目评定结果类似 ,有 3项英国医生的评分高于中国医生 ,有 9项中国医生评分高于英国医生 ,其中 1项具有显著性差异。结论 :对行为表现和症状认知的文化差异可能使流行病学的研究出现不同的结果 ,即使使用统一的诊断标准和症状评分量表作为诊断工具 ,不同文化背景的国家 ,儿童多动症的患病率仍然可不一致 相似文献
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Jack Martin Angelica Petrillo Elizabeth C Smyth Nadeem Shaida Samir Khwaja HK Cheow Adam Duckworth Paula Heister Raaj Praseedom Asif Jah Anita Balakrishnan Simon Harper Siong Liau Vasilis Kosmoliaptsis Emmanuel Huguet 《World journal of clinical oncology》2020,11(10):761-808
The liver is the commonest site of metastatic disease for patients with colorectal cancer, with at least 25% developing colorectal liver metastases (CRLM) during the course of their illness. The management of CRLM has evolved into a complex field requiring input from experienced members of a multi-disciplinary team involving radiology (cross sectional, nuclear medicine and interventional), Oncology, Liver surgery, Colorectal surgery, and Histopathology. Patient management is based on assessment of sophisticated clinical, radiological and biomarker information. Despite incomplete evidence in this very heterogeneous patient group, maximising resection of CRLM using all available techniques remains a key objective and provides the best chance of long-term survival and cure. To this end, liver resection is maximised by the use of downsizing chemotherapy, optimisation of liver remnant by portal vein embolization, associating liver partition and portal vein ligation for staged hepatectomy, and combining resection with ablation, in the context of improvements in the functional assessment of the future remnant liver. Liver resection may safely be carried out laparoscopically or open, and synchronously with, or before, colorectal surgery in selected patients. For unresectable patients, treatment options including systemic chemotherapy, targeted biological agents, intra-arterial infusion or bead delivered chemotherapy, tumour ablation, stereotactic radiotherapy, and selective internal radiotherapy contribute to improve survival and may convert initially unresectable patients to operability. Currently evolving areas include biomarker characterisation of tumours, the development of novel systemic agents targeting specific oncogenic pathways, and the potential re-emergence of radical surgical options such as liver transplantation. 相似文献
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多层螺旋CT评价先天性单冠状动脉畸形 总被引:1,自引:0,他引:1
目的 探讨16层螺旋CT(MSCT)冠状动脉造影诊断先天性单冠状动脉畸形的价值。资料与方法 回顾性分析4例先天性单冠状动脉患者的MSCT和常规X线冠状动脉造影(CCA)资料。对比两者在显示和诊断此病中的差异。仿真内镜技术用于评价异位开口及其与邻近正常冠状动脉开口的关系,多平面重建、曲面多平面重建、最大密度投影、容积成像等重建方法则用于评价变异冠状动脉的行径及其与邻近大血管的关系。结果 4例患者变异的冠状动脉全部为MSCT造影所显示并明确诊断。MSCT显示3例患者的左主干起源于右冠状动脉的近段,其中1例在CCA中左主干仅近段局部显影,未能明确诊断,另2例左冠状动脉虽显影,但较淡。1例右冠状动脉起源于左主干的末端,CCA则误为起源于回旋支。MSCT显示2例异常开口冠状动脉的近段狭窄,3支异常冠状动脉穿过主动脉根部和肺动脉或右室流出道的间隙,1支绕主动脉根部后方走行,而CCA均不能明确诊断。结论 MSCT显示先天性单冠状动脉明显优于CCA,凡疑及冠状动脉变异的患者,可首选非创伤性的MSCT冠状动脉造影检查。 相似文献
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重组人BAFF112-285的制备及活性分析 总被引:1,自引:3,他引:1
目的 制备具有功能活性的重组人TNF家族的B细胞激活因子(B cell activating factor belonging to the TNF family,BAFF)胞外区112—285氨基酸残基段(rhBAFF112—285),为BAFF的深人研究奠定基础。方法 提取人HL-60细胞总RNA,经RT—PCR扩增编码人BAFF胞外区112—285氨基酸残基(BAFF112—285)的cDNA,行序列测定后,构建于原核表达载体pQE—80L并转化大肠杆菌DH5α,经IPTG诱导表达rhBAFF112—285,Ni^2 —NTA层析纯化,进而经^3H—TdR掺人实验检测其免疫学活性。结果 RT—PC双扩增得到了525bp的DNA片段,序列分析与GenBank中报道的编码人BAFF112—285的cDNA序列一致,该胞外区片段在大肠杆菌中获得了高效表达,表达水平达细菌总蛋白的45.7%,经纯化后纯度可达98.4%,活性检测证实其能明显刺激外周血淋巴细胞活化。结论 利用大肠杆菌可高效表达rhBAFF112—285,所获纯化产物具有生物学活性,所获结果为进一步研究创造了条件。 相似文献
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