全文获取类型
收费全文 | 5647篇 |
免费 | 418篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 161篇 |
妇产科学 | 130篇 |
基础医学 | 956篇 |
口腔科学 | 80篇 |
临床医学 | 563篇 |
内科学 | 1268篇 |
皮肤病学 | 168篇 |
神经病学 | 659篇 |
特种医学 | 109篇 |
外科学 | 534篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 430篇 |
眼科学 | 51篇 |
药学 | 402篇 |
中国医学 | 10篇 |
肿瘤学 | 530篇 |
出版年
2024年 | 8篇 |
2023年 | 51篇 |
2022年 | 129篇 |
2021年 | 195篇 |
2020年 | 91篇 |
2019年 | 145篇 |
2018年 | 167篇 |
2017年 | 153篇 |
2016年 | 190篇 |
2015年 | 220篇 |
2014年 | 244篇 |
2013年 | 328篇 |
2012年 | 487篇 |
2011年 | 516篇 |
2010年 | 286篇 |
2009年 | 261篇 |
2008年 | 409篇 |
2007年 | 376篇 |
2006年 | 353篇 |
2005年 | 346篇 |
2004年 | 300篇 |
2003年 | 279篇 |
2002年 | 231篇 |
2001年 | 29篇 |
2000年 | 20篇 |
1999年 | 32篇 |
1998年 | 47篇 |
1997年 | 36篇 |
1996年 | 28篇 |
1995年 | 24篇 |
1994年 | 16篇 |
1993年 | 19篇 |
1992年 | 9篇 |
1991年 | 15篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
1963年 | 1篇 |
排序方式: 共有6097条查询结果,搜索用时 0 毫秒
991.
Manuela G. Neuman Loida Oruña Gabriel Coto Guillermo Lago Radu Nanau Marc Vincent 《Clinical biochemistry》2010,43(10-11):822-826
Ethanol is commonly used in cosmetic and pharmaceutical preparations.ObjectiveThe present study aimed to assess ethanol-induced apoptosis and the possible repair by hyaluronic acid (HA) in vitro. In addition we aimed to determine the modulation of tumor necrosis factor (TNF-α) and interferon (IFN-α).Design and methodsWe treated human A431 epidermoid skin cells and mouse fibroblasts with two concentrations of ethanol for 24 h. HA obtained from umbilical cord excision was used at three concentration levels (2%, 4% and 8%) to determine its efficacy in the treatment. We measured cytotoxicity, TNF-α and IFN-α and visualized the cultures by electron microscopy.ResultsTreatment of cells with ethanol at 50 mM and 100 mM increased both the percentage of cells undergoing apoptosis, as well as the release of TNF-α into the culture medium.ConclusionsEthanol may induce apoptosis in skin cells by enhancing the effects of TNF-α. HA in the 2% and 4% concentrations reduced TNF-α and morphological inflammation both in human A431 epidermoid skin cells and in mouse fibroblasts. 相似文献
992.
993.
994.
995.
Manuela Gander Carol George Dan Pokorny Anna Buchheim 《Child psychiatry and human development》2017,48(2):270-282
The contribution of attachment to human development and clinical risk is well established for children and adults, yet there is relatively limited knowledge about attachment in adolescence due to the poor availability of construct valid measures. The Adult Attachment Projective Picture System (AAP) is a reliable and valid instrument to assess adult attachment status. This study examines for the first time the discriminant validity of the AAP in adolescents. In our sample of 79 teenagers between 15 and 18 years, 42 % were classified as secure, 34 % as insecure-dismissing, 13 % as insecure-preoccupied and 11 % as unresolved. The results demonstrated discriminant validity for using the AAP in that age group, with no associations between attachment classifications and verbal intelligence, social desirability, story length or sociodemographic variables. These results poise the AAP to be used in clinical intervention and large-scale research investigating normative and atypical developmental correlates and sequelae of attachment, including psychopathology in adolescence. 相似文献
996.
Vocabulary acquisition represents a major challenge in foreign language learning. Research has demonstrated that gestures accompanying speech have an impact on memory for verbal information in the speakers' mother tongue and, as recently shown, also in foreign language learning. However, the neural basis of this effect remains unclear. In a within‐subjects design, we compared learning of novel words coupled with iconic and meaningless gestures. Iconic gestures helped learners to significantly better retain the verbal material over time. After the training, participants' brain activity was registered by means of fMRI while performing a word recognition task. Brain activations to words learned with iconic and with meaningless gestures were contrasted. We found activity in the premotor cortices for words encoded with iconic gestures. In contrast, words encoded with meaningless gestures elicited a network associated with cognitive control. These findings suggest that memory performance for newly learned words is not driven by the motor component as such, but by the motor image that matches an underlying representation of the word's semantics. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc. 相似文献
997.
Manuela Santini Sabatino Fabri Paolo Sagnelli Mario Manfredi Ada Francia 《European journal of neurology》1999,6(1):91-93
Botulism is a widespread neuroparalytic disease that may be confused with other neurological disorders. As it is potentially lethal, clinicians are required to be aware of its diagnosis and management. We report a case of botulism complicated by pyramidal signs in a 35-year-old woman. Clinical aspects, differential diagnoses and therapeutic problems are discussed. 相似文献
998.
Atefe Abdolmanafi Sam Winter Reza Ghorban Jahromi Hojatollah Farahani Maria Manuela Peixoto Pedro Nobre 《Sexual and Relationship Therapy》2019,34(1):109-120
The aim of this study was to translate and adapt to Persian, and to assess psychometric properties of the Questionnaire of Cognitive Schema Activation in Sexual Context (QCSASC). A total of 265 Iranian participants (121 women and 144 men) were recruited for this study. A principal component analysis (PCA) with varimax rotation and subsequent confirmatory factor analysis revealed a best fitting five-factor structure similar to the original QCSASC: Incompetence, Undesirability, Abandon/Rejection, Powerless/Helpless, and Difference. However, in the Iranian sample, the original Self-Depreciation dimension was included in the Incompetence and Undesirability factors. An Abandon/Rejection dimension was also evident, and may be explained by cultural, social, and religious factors in the Iranian culture. Additionally, reliability analysis has supported the internal consistency (adequate Cronbach's alpha values) and temporal stability (test–retest reliability) of the QCSASC in an Iranian sample. The findings suggest the adequacy of the Persian version of the QCSASC to assess cognitive schemas in sexual context among Iranian men and women. 相似文献
999.
1000.
Roberta Soscia Irene Della Starza Lucia Anna De Novi Caterina Ilari Michela Ansuinelli Marzia Cavalli Vittorio Bellomarino Luciana Cafforio Mariangela Di Trani Giovanni Cazzaniga Grazia Fazio Alessandra Santoro Domenico Salemi Orietta Spinelli Manuela Tosi Carolina Terragna Valentina Robustelli Teresa Bellissimo Gioia Colafigli Massimo Breccia Sabina Chiaretti Alice Di Rocco Maurizio Martelli Anna Guarini Ilaria Del Giudice Robin Foà 《Hematological oncology》2023,41(1):50-60
Circulating tumor DNA (ctDNA) has become the most investigated analyte in blood. It is shed from the tumor into the circulation and represents a subset of the total cell-free DNA (cfDNA) pool released into the peripheral blood. In order to define if ctDNA could represent a useful tool to monitor hematologic malignancies, we analyzed 81 plasma samples from patients affected by different diseases. The results showed that: (i) the comparison between two different extraction methods Qiagen (Hilden, Germany) and Promega (Madison, WI) showed no significant differences in cfDNA yield, though the first recovered higher amounts of larger DNA fragments; (ii) cfDNA concentrations showed a notable inter-patient variability and differed among diseases: acute lymphoblastic leukemia and chronic myeloid leukemia released higher amounts of cfDNA than chronic lymphocytic leukemia, and diffuse large B-cell lymphoma released higher cfDNA quantities than localized and advanced follicular lymphoma; (iii) focusing on the tumor fraction of cfDNA, the quantity of ctDNA released was insufficient for an adequate target quantification for minimal residual disease monitoring; (iv) an amplification system proved to be free of analytical biases and efficient in increasing ctDNA amounts at diagnosis and in follow-up samples as shown by droplet digital PCR target quantification. The protocol has been validated by quality control rounds involving external laboratories. To conclusively document the feasibility of a ctDNA-based monitoring of patients with hematologic malignancies, more post-treatment samples need to be evaluated. This will open new possibilities for ctDNA use in the clinical practice. 相似文献