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Mansoureh Shabani Zanjani Roya Nasirzadeh Seyed-Mohammad Fereshtehnejad Ladan Yoonesi Asl Seyed-Amir Pooya Alemzadeh Sareh Askari 《Acta neurologica Belgica》2014,114(1):15-23
Gestational diabetes mellitus (GDM) is one of the most common complications in pregnancies. Evaluating other conditions, including intra uterine growth restriction and pre-eclampsia, some studies have shown significant changes in blood flow velocity of fetal middle cerebral artery (MCA). Our study is one of the few that has aimed to assess the effects of GDM on Doppler parameters of the fetal MCA and umbilical artery (UA) and to compare with normal pregnancies. This cross-sectional study was performed on 66 pregnant women, including 33 women with GDM and the others without it, in Akbar-Abadi University Hospital in Tehran, Iran during 2010–2011. Peak systolic and diastolic velocities, pulsatility index (PI), resistance index (RI) and systolic diastolic ratio (SD) were recorded in UA as well as both right and left fetal MCAs for every recruited pregnant women by means of Doppler ultrasonography. The mean gestational age at the time of examination was 34.45 (SD = 2.62) weeks in GDM group. Although all of the measured Doppler parameters had higher values in GDM pregnancies, the differences were not significant between two groups of study; except for the left fetal MCA-PI, which was significantly higher in GDM group [2.07 (SD = 0.07) vs. 1.85 (SD = 0.74), P = 0.03]. Our results show that gestational diabetes may contribute to an elevated PI in the fetal MCA. Although there is not yet strong proof for the effect of GDM on the fetal brain hemodynamics, the significant higher MCA-PI warrants more attention towards better controlling of the hyperglycemia during pregnancy. 相似文献
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Mahnaz Khanavi Mansoureh Sabbagh-Bani-Azad Amir Hossein Abdolghaffari Mahdi Vazirian Isa Isazadeh Mohammad Amin Rezvanfar Maryam Baeeri Azadeh Mohammadirad Roja Rahimi Mohammad Reza Shams-Ardekani Mohammad Abdollahi 《Archives of Medical Science》2014,10(6):1225-1234
Introduction
In this study we investigated the effect of gall of Quercus brantii Lindl., a traditional Iranian medicine, in a murine model of experimental colitis induced in male rats by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS).Material and methods
Quantification of the main active components was done for estimation of total phenolic content and free gallic acid. Gall of Quercus brantii Lindl. in two forms (gall powder and gall hydro alcoholic extract) was gavaged for 10 days (500 mg/kg). Ten days after induction of colitis, colonic status was examined by macroscopic, microscopic and biochemical analyses. Colonic tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were analyzed as biomarkers of inflammatory condition. To determine the role of oxidative stress (OS) in colitis, the levels of cellular lipid peroxidation (LPO), total antioxidant power (TAP) and myeloperoxidase (MPO) were measured in colon tissues.Results
TNBS-induced colitis exhibited a significant increase in colon MPO activity and concentrations of cellular LPO, TNF-α and IL-1β, while TAP was significantly reduced. Microscopic evaluations of the colonic damage in the colitis group revealed multifocal degenerative changes in the epithelial lining and areas of necrosis, extensive mucosal and sub-mucosal damage with congested blood vessels, edema and hemorrhages along with extensive infiltration of inflammatory cells. Parameters including macroscopic and microscopic scores, TNF-α, IL-1β, LPO, TAP and MPO improved by both gall extract and gall powder of Quercus brantii Lindl. and reached close to normal levels. The level of total phenols (GAE/100 g of sample) and free gallic acid were estimated to be 88.43 ±7.23 (mean ± SD) and 3.74% of dry weight, respectively.Conclusions
The present study indicates that the gall of Quercus brantii Lindl. is able to exert antioxidative and anti-inflammatory effects on the biochemical and pathological parameters of colitis. 相似文献15.
Epididymal leiomyosarcoma (LMS) is a rare malignancy. Because the risk of recurrence is high, proper approach is important. Here, we present a patient with scrotal swelling who underwent surgical excision via scrotal incision, and the histopathological diagnosis was epididymal LMS. The decision was then made to perform inguinal radical orchiectomy. 相似文献
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Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice 总被引:4,自引:0,他引:4
Marten K Bremer C Khazaie K Sameni M Sloane B Tung CH Weissleder R 《Gastroenterology》2002,122(2):406-414
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Channels were activated, in ripped-off patches from rat-cultured hippocampal neurons, by propofol alone, propofol plus 0.5 μM GABA (γ-aminobutyric acid) or GABA alone. The propofol-activated currents were chloride-selective, showed outward-rectification and were enhanced by 1 μM diazepam. The maximum propofol-activated channel conductance increased with propofol concentration from less than 15 pS (10 μM) to about 60 pS (500 μM) but decreased to 40 pS in 1 mM propofol. Fitting the data from 10 to 500 μM propofol with a Hill-type equation gave a maximum conductance of 64 pS, an EC50 value of 32 μM and a Hill coefficient of 1.1. Addition of 0.5 μM GABA shifted the propofol EC50 value to 10 μM and increased the maximum channel conductance to about 100 pS. The Hill coefficient was 0.8. The maximum channel conductance did not increase further when 1 μM diazepam was added together with a saturating propofol concentration and GABA. The results are compared to effects other drugs have on GABAA channels conductance. 相似文献
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Tahereh Najafi‐Ghezeljeh MS Inger Ekman RN PhD Mansoureh Yadavar Nikravesh PhD Azita Emami RN RNT PhD 《International journal of nursing practice》2008,14(6):470-476
Research aimed at evaluating Angina Pectoris (AP) symptoms in patients with Coronary Heart Disease (CHD) requires a comprehensive assessment tool applicable to this population. Because no single existing measure assessed the full range of symptom characteristics important to our study, we combined two measures (the modified Rose Questionnaire (MRQ), and the Short Form‐McGill Pain Questionnaire (SF‐MPQ) and added one item to examine specific aspects of AP symptoms (Accompanying Symptom Checklist). The purposes of this study are: (i) to describe the process of translating the SF‐MPQ, MRQ and accompanying symptom checklist from English to the Farsi language; and (ii) to evaluate substantial psychometric works (content and construct validity) for the entire instrument and each part of it (SF‐MPQ, MRQ and accompanying symptom checklist). A cross‐cultural adaptation of the instrument was carried out before developing the final version of it. To these ends, one hundred and 10 CHD patients with AP were assessed by this hybrid measure in an initial study. An analysis of the results indicated that a content valid instrument had been developed. There was a significantly high correlation between scores in the SF‐MPQ and there were associations between items in the MRQ. The Iranian version of AP characteristics questionnaire is valid; it is capable of describing characteristics of AP symptoms. However, the reliability of the instrument needs to be assessed through further research. 相似文献
20.
Yasmine Neirijnck Antoine Reginensi Kirsten Y. Renkema Filippo Massa Vladimir M. Kozlov Haroun Dhib Ernie M.H.F. Bongers Wout F. Feitz Albertien M. van Eerde Veronique Lefebvre Nine V.A.M. Knoers Mansoureh Tabatabaei Herbert Schulz Helen McNeill Franz Schaefer Michael Wegner Elisabeth Sock Andreas Schedl 《Kidney international》2018,93(5):1142-1153