Peripheral blood stem cell transplantation: Impact on procedure load and workload in an apheresis unit

Peripheral blood stem cells (PBSC) reinfusion appears to hasten hematologic reconstitution following myeloablative therapy. While procurement of PBSC adds apheresis procedures, rapid engraftment could decrease the demand for platelet transfusions. To determine the impact of PBSC collection on workload in our apheresis unit, we studied 3 consecutive groups of patients with metastatic breast cancer given comparable high-dose chemotherapy and autologous bone marrow transplant, with or without PBSC or granulocyte-colony stimulating factor (G-CSF). Forty-one transplants were performed with bone marrow cells only: 31 patients (Group A) did not receive G-CSF, while the following 10 patients (group B) received daily G-CSF until neutrophil engraftment. Bone marrow cells and PBSC were used for the most recent 11 transplants (group C), followed by daily G-CSF until engraftment. PBSC were mobilized with cyclophosphamide (4 g/m²) and etoposide (1 g/m²), followed by G-CSF, 8 μg/kg/day. PBSC collection was carried out on a Fenwal CS3000 + cell collector, using modified procedure 1, to obtain a minimum of 5 × 10⁸ mononuclear cells/kg. The times to neutrophil count over 500/μL, platelet count over 20,000/μL, and discharge from the hospital after transplant were significantly shorter for patients in group C (medians of 8, 8, and 21 days, respectively) compared to group A (medians of 14, 14, and 29 days; P = 0.001) or group B (medians of 11, 24, and 32 days; P < 0.001). The number of single-donor platelet equivalents transfused (1 SDE = 1 unit of single-donor platelets or 8 pooled random-donor platelets) was significantly decreased in group C (median = 4) compared to group A (median = 19) and group B (median = 11; P = 0.001 for both comparisons). The total apheresis procedure load (the sum of SDE and PBSC collection for each transplant) was significantly decreased in group C (median = 6) compared to groups A and B combined (median = 14; P = 0.001). The apheresis unit workload assessing apheresis durations per patient, calculated as 2 × SDE + 4 × PBSC, was also significantly reduced in group C (median = 16) compared to groups A and B (median = 28; P = 0.002). Thus, PBSC were advantageous in terms of faster engraftment, reduced platelet transfusions, and shorter hospitalization, while decreasing both procedure load and net workload per patient in the apheresis unit. © 1992 Wiley-Liss, Inc.     

Facial injuries associated with cervical fractures: recognition, patterns, and management

Publications in both the orthopedic and maxillofacial literature have noted the association of cervical spine and facial injuries. However, because the incidence of spinal injury is low, we found no study which documented the relationship between maxillofacial and cervical spine injuries. The present study reviewed 982 cervical spine injuries in two major trauma centers, finding a 19.3% incidence of facial injury. Fourteen per cent of patients had soft-tissue injuries and 8.6%, facial fractures. Important relationships were noted between fractures of the mandible and upper cervical spine, and soft-tissue injuries of the upper face and fractures of the lower cervical spine. Methods of care adapted to the combined injuries are described. The study concludes that examination of the face for soft-tissue and bony injuries may give important clues on the direction and intensity of the force injuring the cervical spine.     

Gingival inflammation and bone loss in periodontal disease

Fifty subjects between 27 and 43 years of age were studied to determine the relationship between the severity of gingival inflammation, the amount of bone loss and the plaque score in interproximal sites. The results indicate moderately good correlations between Gingival Index or Plaque Index and percentage bone loss. However a low correlation was found between the amount of crevicular fluid and percentage loss. Gingival Index and Plaque Index were well correlated. It was also found that when patients were divided into two age groups, younger and older than 35 years, the older individuals studied had more bone loss interproximally compared with the younger despite comparable amounts of plaque or gingival inflammation. The data suggest that both severity and longevity of the inflammation may play a role in determining the rate of alveolar bone resorption.     

Imatinib mesylate: an attractive alternative in young children with large, surgically challenging dermatofibrosarcoma protuberans

To document the clinical activity of imatinib mesyalte in a child with a dermatofibrosarcoma protuberans (DFSP). An 18-month-old girl presented with a large extremity DFSP. As surgical resection would have caused unacceptable functional defects, imatinib mesylate was administered to induce tumor reduction and or stabilization. After 23 weeks of therapy, magnetic resonance imaging (MRI) of the tumor showed a reduction in the subcutaneous thickness in the transverse plane. The drug was tolerated well without any adverse reactions. Imatinib mesylate offers a non-surgical alternative for the treatment of large DFSP in children.     

Past physical activity, current physical activity, and risk of coronary heart disease

PURPOSE: Middle-aged and older women who are physically active have decreased risk of coronary heart disease (CHD); however, little is known about how physical activity during young adulthood influences activity during middle age and older, and CHD risk. We examined the relationship between 1) physical activity during young adulthood and middle age, and 2) physical activity during each time period and CHD occurring in middle age or older. METHODS: Cohort study of 39,876 healthy U.S. female health professionals, age > or = 45 yr, in the Women's Health Study. Physical activity was reported at baseline. Additionally, physical activity in high school and age 18-22 yr was reported on the 24-month follow-up survey. Women were followed for an average of 9 yr, after the 24-month survey, for CHD occurrence (N = 477). RESULTS: Among 37,169 eligible participants at baseline, the most active women (vigorous physical activity 10-12 months x yr) during high school and age 18-22 yr were more than twice as likely to meet physical activity recommendations at baseline than the least active women (no vigorous activity) during high school and age 18-22 yr (multivariate-adjusted odds ratio = 2.43; 95% C.I. 2.24, 2.63). At baseline, the most active women (> or = 1500 kcal x wk(-1)) had a 39% lower risk of CHD during follow-up than the least active (<200 kcal x wk(-1)) (multivariate-adjusted relative risk = 0.61; 95% C.I. 0.46, 0.81). However, physical activity during young adulthood was not associated with risk of CHD occurring during middle age and older. CONCLUSION: Women who are physically active during young adulthood are more likely to be active when middle-aged and older, when rates of CHD increase, and physical activity during middle-age predicts lower risk of CHD.