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151.
David Baud Didier Musso Manon Vouga Marco P. Alves Nicolas Vulliemoz 《American journal of reproductive immunology (New York, N.Y. : 1989)》2017,77(2)
Zika virus (ZIKV) was first isolated in 1947 in a rhesus monkey from the Zika forest of Uganda. Until 2007, only 14 human cases were reported. The first large human outbreak occurred in 2007 (Yap Island, Federated States of Micronesia, Pacific) followed by French Polynesia in 2013 and Brazil in 2015. The virus is mainly transmitted through Aedes mosquito bites, but sexual and post‐transfusion transmissions have been reported. Symptoms include low‐grade fever, maculopapular rash, conjunctivitis, myalgia, arthralgia, and asthenia. During the recent outbreaks in French Polynesia and Brazil, ZIKV infection has been associated with two major complications: microcephaly and Guillain–Barré syndrome. Since fetal infection includes other birth defects, congenital Zika syndrome has been used to define in utero infection. The majority of sexual transmission occurred from a symptomatic male to a female, but female‐to‐male and male‐to‐male transmission have been reported. Asymptomatic male‐to‐female transmission has also been described. Importantly, ZIKV RNA can persist at least 6 months in semen. The male urogenital tract may therefore act as a reservoir for the virus. ZIKV RNA was detected in a cervical swab of a patient 3 days after presenting the classic symptoms suggesting a potential tropism for the female genital tract. Long‐lasting presence of ZIKV RNA might not indicate that the individual is infectious but makes recommendation for couples potentially exposed to the virus and willing to conceive difficult. It will also be important to determine whether genital ZIKV infection might have a deleterious effect on male and female fertility. 相似文献
152.
153.
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind,placebo-controlled trial 总被引:56,自引:0,他引:56
Gionchetti P Rizzello F Helwig U Venturi A Lammers KM Brigidi P Vitali B Poggioli G Miglioli M Campieri M 《Gastroenterology》2003,124(5):1202-1209
BACKGROUND & AIMS: We have recently documented the efficacy of a highly concentrated probiotic preparation (VSL#3) in the prevention of flare-up in patients with chronic pouchitis. The aim of this study was to compare probiotic therapy with VSL#3 versus placebo in the ability to prevent the onset of acute pouchitis during the first year after ileal pouch-anal anastomosis. METHODS: Forty consecutive patients who underwent ileal pouch-anal anastomosis for ulcerative colitis were randomized to receive either VSL#3 (1 packet containing 900 billion bacteria/day) (n = 20) or an identical placebo (n = 20) immediately after ileostomy closure for 1 year. The patients were assessed clinically, endoscopically, and histologically after 1, 3, 6, 9, and 12 months. Health-related quality of life was assessed using the Inflammatory Bowel Disease Questionnaire. RESULTS: Two of the 20 patients (10%) treated with VSL#3 had an episode of acute pouchitis compared with 8 of the 20 patients (40%) treated with placebo (log-rank test, z = 2.273; P < 0.05). Treatment with VSL#3 determined a significant improvement in Inflammatory Bowel Disease Questionnaire score, whereas this was not the case with placebo. CONCLUSIONS: Treatment with VSL#3 is effective in the prevention of the onset of acute pouchitis and improves quality of life of patients with ileal pouch-anal anastomosis. 相似文献
154.
Increased effective lung volume following lung volume reduction surgery in emphysema 总被引:6,自引:0,他引:6
STUDY OBJECTIVES: Lung volume reduction surgery (LVRS) for emphysema has a variable effect on spirometry with improvement linked to increases in lung elastic recoil. The mechanism by which recoil increases following LVRS has not been described completely. This study examines preoperative and postoperative pulmonary function to describe a mechanism for changes in airflow obstruction. DESIGN: Change in pulmonary function following LVRS. Setting : Public teaching hospital in Australia. PATIENTS: Patients with severe emphysema and pulmonary function measurements made before and after LVRS. MEASUREMENTS: Routine pulmonary function testing performed with ventilated lung alveolar volume (VA) derived from the gas transfer measurement used as a proxy for the effective lung volume. RESULTS: Pulmonary function tests from 36 consecutive patients with measurements made at the same laboratory were analyzed. The mean FEV(1) was 29.1% predicted presurgery and increased following LVRS from 0.900 L (SD, 0.427 L) to 1.283 L (SD, 0.511 L; p < 0.0001) and TLC (143% predicted) decreased from 8.19 L (SD, 1.492 L) to 7.07 L (SD, 1.52 L; p < 0.0001; n = 35). The mean VA increased by 0.674 L (SD, 0.733 L) from 4.04 to 4.72 L (p < 0.0001; n = 34). The change in FEV(1) correlated well with the change in VA (r = 0.63). The change in FEV(1) in those patients whose VAs did not increase (n = 7) was not significant. CONCLUSIONS: The increase in VA reflects an increase of functional or ventilating lung volume and is associated with an improvement in spirometry following LVRS. 相似文献
155.
Absence or low IGF‐1R‐expression in esophageal adenocarcinoma is associated with tumor invasiveness and radicality of surgical resection 下载免费PDF全文
156.
Truchon M Schmouth MÈ Côté D Fillion L Rossignol M Durand MJ 《Journal of occupational rehabilitation》2012,22(1):27-50
Introduction: Over the last decades, psychosocial factors were identified by many studies as significant predictive variables in the development
of disability related to common low back disorders, which thus contributed to the development of biopsychosocial prevention
interventions. Biopsychosocial interventions were supposed to be more effective than usual interventions in improving different
outcomes. Unfortunately, most of these interventions show inconclusive results. The use of screening questionnaires was proposed
as a solution to improve their efficacy. The aim of this study was to validate a new screening questionnaire to identify workers
at risk of being absent from work for more than 182 cumulative days and who are more susceptible to benefit from prevention
interventions. Methods: Injured workers receiving income replacement benefits from the Quebec Compensation Board (n = 535) completed a 67-item questionnaire in the sub-acute stage of pain and provided information about work-related events
6 and 12 months later. Reliability and validity of the 67-item questionnaire were determined respectively by test–retest reliability
and internal consistency analysis, as well as by construct validity analyses. The Cox regression model and the maximum likelihood
method were used to fix a model allowing calculation of a probability of absence of more than 182 days. Criterion validity
and discriminative capacity of this model were calculated. Results: Sub-sections from the 67-item questionnaire were moderately to highly correlated 2 weeks later (r = 0.52–0.80) and showed moderate to good internal consistency (0.70–0.94). Among the 67-item questionnaire, six sub-sections
and variables (22 items) were predictive of long-term absence from work: fear-avoidance beliefs related to work, return to
work expectations, annual family income before-taxes, last level of education attained, work schedule and work concerns. The
area under the ROC curve was 73%. Conclusions: The significant predictive variables of long-term absence from work were dominated by workplace conditions and individual
perceptions about work. In association with individual psychosocial variables, these variables could contribute to identify
potentially useful prevention interventions and to reduce the significant costs associated with LBP long-term absenteeism. 相似文献
157.
158.
Recently, the guideline for prevention, screening and intervention in respect of overweight in children for the Youth Health Care practice has been published in an abbreviated form in NTvG. Childhood overweight is an important public health problem that requires preventive actions from early age onwards, especially in immigrant groups. Although this guideline provides a basis for (preventive) actions within Youth Health Care, the author argues that a community based approach including specific prevention and intervention strategies for ethnic groups is needed for successful implementation. 相似文献
159.
Hammer D Anderson MB Brunson WD Grus C Heun L Holtman M Mashima T McGuinn K Nunez L Register S Ross L Ruffin A Frost JG 《Journal of allied health》2012,41(2):e49-e53
The Interprofessional Professionalism Collaborative (IPC), convened in 2006, currently consists of 11 national organizations representing health professions programs at the doctoral entry level, and is developing a framework of "interprofessional professionalism" (IPP) around observable behaviors that illustrate what professionalism looks like in the context of interprofessional collaborations focused on patient-, client-, and family-centered care. IPC's goal is to create tools to foster and measure these behaviors in health professionals and students. This paper describes the work of IPC to date and its future plans. 相似文献
160.
Ruffin MT Hade EM Gorsline MR DeGraffinreid CR Katz ML Kobrin SC Paskett ED 《Vaccine》2012,30(36):5349-5357